Hemodynamic Changes Associated with Two Different Concentrations of Adrenaline in Lignocaine Solution: A Comparative Analysis

Abstract

Local anesthetic (LA) agents are commonly employed during surgical procedures in dentistry to control pain. There are a variety of LA agents available in the market with different concentration of adrenaline added to increase the efficacy. The systemic effects of adrenaline used as vasoconstrictors in LA solution are short lived or transient in nature; however, there are instances of associated cardiovascular problems. This study compares the efficacy and cardiovascular effects with the use of 2% lignocaine with two different concentrations of adrenaline.

Effect of Local Anaesthesia with and without Adrenaline on Blood Pressure, Pulse Rate and Oxygen Saturation - A Comparative Study

“…Shakeel et al 21 in 2019 studied the impact and changes associated with oxygen saturation in different adrenaline concentration 1:80000 and 1:200000 and found no statistically significant change which is in accordance with our findings.…”

Peri-operative Hemodynamic changes and Anxiety in patients undergoing surgical and LASER assisted periodontal therapies- A randomised clinical trial

“…They reported a considerable increase in pulse rate immediately after LA with 1:80,000 adrenaline concentrations, which progressively decreased to the normal rate after 15 minutes, and no significant increase in pulse rate with a 1:2,00,000 adrenaline concentration. 20 However when compared to earlier studies the rise in hemodynamicswas slightly less in our study and the rise has reduced at a faster rate to pre-operative values, which may be due to the 1:2,00,000 concentration of epinephrine used which is a commonly used concentration in regular practice. 21 Another important factor in the hemodynamic changes associated with LA is the amount of LA injected, hence in the current study a standard amount of up to two cartridges was considered as inclusion criteria.…”