Hemodynamic aspects of reduced platelet adhesion on bioinspired microstructured surfaces

Pham, Tam T.; Wiedemeier, Stefan; Maenz, Stefan; Gastrock, Gunter; Settmacher, Utz; Zanow, Jürgen; Lüdecke, Claudia; Bossert, Jörg

doi:10.1016/j.colsurfb.2016.05.022

Cited by 25 publications

(33 citation statements)

References 27 publications

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“…However, this geometry differs from that of a plaque. In fact, the shear‐rate gradient of a microstructured surface in the Wenzel state was hypothesized to be even beneficial …”

Section: Discussion On Superhydrophobicity and Platelet Antiadhesionmentioning

confidence: 99%

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Superhydrophobic Blood‐Repellent Surfaces

et al. 2018

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Superhydrophobic surfaces repel water and, in some cases, other liquids as well. The repellency is caused by topographical features at the nano-/microscale and low surface energy. Blood is a challenging liquid to repel due to its high propensity for activation of intrinsic hemostatic mechanisms, induction of coagulation, and platelet activation upon contact with foreign surfaces. Imbalanced activation of coagulation drives thrombogenesis or formation of blood clots that can occlude the blood flow either on-site or further downstream as emboli, exposing tissues to ischemia and infarction. Blood-repellent superhydrophobic surfaces aim toward reducing the thrombogenicity of surfaces of blood-contacting devices and implants. Several mechanisms that lead to blood repellency are proposed, focusing mainly on platelet antiadhesion. Structured surfaces can: (i) reduce the effective area exposed to platelets, (ii) reduce the adhesion area available to individual platelets, (iii) cause hydrodynamic effects that reduce platelet adhesion, and (iv) reduce or alter protein adsorption in a way that is not conducive to thrombus formation. These mechanisms benefit from the superhydrophobic Cassie state, in which a thin layer of air is trapped between the solid surface and the liquid. The connections between water- and blood repellency are discussed and several recent examples of blood-repellent superhydrophobic surfaces are highlighted.

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“…However, this geometry differs from that of a plaque. In fact, the shear‐rate gradient of a microstructured surface in the Wenzel state was hypothesized to be even beneficial …”

Section: Discussion On Superhydrophobicity and Platelet Antiadhesionmentioning

confidence: 99%

“…The boundary layer near an SHB surface has lower shear and a macroscopic slip velocity, which can alter platelet-adhesion dynamics. [32,37,38] 4. Protein adsorption (Figure 3d)…”

Section: Mechanismmentioning

confidence: 99%

Superhydrophobic Blood‐Repellent Surfaces

et al. 2018

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“…Besides the height of protrusion, the interspacing area between the protrusion was also reported to be a crucial factor in platelet adhesion (Figure 3). The shear stress difference is lower as the interspacing between the protrusion is reduced [63]. Extreme roughness of the surface (<50 nm), on the contrary, has little influence on platelet adhesion.…”

Section: Antithrombotic Effect Of Superhydrophobic Surfacementioning

confidence: 95%

Potential of Superhydrophobic Surface for Blood-Contacting Medical Devices

Liew

et al. 2021

IJMS

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Medical devices are indispensable in the healthcare setting, ranging from diagnostic tools to therapeutic instruments, and even supporting equipment. However, these medical devices may be associated with life-threatening complications when exposed to blood. To date, medical device-related infections have been a major drawback causing high mortality. Device-induced hemolysis, albeit often neglected, results in negative impacts, including thrombotic events. Various strategies have been approached to overcome these issues, but the outcomes are yet to be considered as successful. Recently, superhydrophobic materials or coatings have been brought to attention in various fields. Superhydrophobic surfaces are proposed to be ideal blood-compatible biomaterials attributed to their beneficial characteristics. Reports have substantiated the blood repellence of a superhydrophobic surface, which helps to prevent damage on blood cells upon cell–surface interaction, thereby alleviating subsequent complications. The anti-biofouling effect of superhydrophobic surfaces is also desired in medical devices as it resists the adhesion of organic substances, such as blood cells and microorganisms. In this review, we will focus on the discussion about the potential contribution of superhydrophobic surfaces on enhancing the hemocompatibility of blood-contacting medical devices.

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“…The blood droplet volumes and their CV values were higher than the respective data for droplets generated from DMEM. This may be due to the higher protein concentration of whole blood that supports interactions with the uncoated channel surface (Pham et al 2016).…”

Section: Microfluidic Experimentsmentioning

confidence: 99%