Precision moulding of biomimetic disposable chips for droplet-based applications

Wiedemeier, Stefan; Romer, Robert H.; Wachter, Stefan; Staps, U.; Kolbe, C.; Gastrock, Gunter

doi:10.1007/s10404-017-2005-5

Cited by 9 publications

(7 citation statements)

References 48 publications

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“…The two predominant research directions include the attempts to reduce the cost and time of mold fabrication or those that aim to improve the functionality of existing methods and materials. An example of the latter can be found in a 2017 research article published by Wiedemeier et al, who presented a method of fabricating a microtopography superhydrophobic surface layer during the injection molding process [31]. The value of such an improvement is applicable in droplet-based microfluidics, where precise formation and movement of liquid droplets is essential, and specifically, in the formation and movement of whole blood, a fluid which has been challenging to incorporate into droplet microfluidics [31].…”

Section: Injection Moldingmentioning

confidence: 99%

A Review of Current Methods in Microfluidic Device Fabrication and Future Commercialization Prospects

et al. 2018

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Microfluidic devices currently play an important role in many biological, chemical, and engineering applications, and there are many ways to fabricate the necessary channel and feature dimensions. In this review, we provide an overview of microfabrication techniques that are relevant to both research and commercial use. A special emphasis on both the most practical and the recently developed methods for microfluidic device fabrication is applied, and it leads us to specifically address laminate, molding, 3D printing, and high resolution nanofabrication techniques. The methods are compared for their relative costs and benefits, with special attention paid to the commercialization prospects of the various technologies.

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Section: Injection Moldingmentioning

confidence: 99%

A Review of Current Methods in Microfluidic Device Fabrication and Future Commercialization Prospects

et al. 2018

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“…Wiedemeier et al. [ 108 ] fabricated COC biomimetic disposable droplet microchannels via injection molding utilizing molds that were microstructured via laser ablation.…”

Section: Fabrication Methodsmentioning

confidence: 99%

A Review of Cyclic Olefin Copolymer Applications in Microfluidics and Microdevices

Agha

Waheed

Alamoodi

et al. 2022

Macro Materials & Eng

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Cyclic olefin copolymers (COC) are amorphous, transparent thermoplastics composed of cyclic olefin monomers (norbornene) and linear olefins (ethene). They are increasingly utilized as fabrication materials for microsystems and microfluidic devices, owing to their promising features of low water absorption, high electrical insulation, long-term stability of surface treatments, and resistance to a broad variety of acids and solvents. Many manufacturing processes for COC-based devices have been developed in recent decades. These methodologies are categorized as replication methods or fast prototyping as common in fabrication of thermoplastic microfluidic devices. This review gives a full discussion of the features of COCs, the various production processes, and the numerous selected applications in microfluidic platforms. The review also explores COC's composition and fundamental features, as well as fabrication processes and applications in a variety of fields, investigates the material's potential advantages and uses, and attempts to create a comprehensive list of COC's possible benefits. Due to their unique features and simplicity of fabrication, COCs are projected to advance the future of microfluidics, microsystems, and optofluidics.

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“…Hydrogels are hydrophilic 3D network structured gels that rapidly expand in water and absorb a lot of water without dissolving in the swelling state [133,160]. Reproduced from [178]. CC BY 4.0.…”

Section: Materials For Different Types Of Microfluidic Devicesmentioning

confidence: 99%

Functional microfluidics: theory, microfabrication, and applications

Xie,

Zhan,

et al. 2024

Int. J. Extrem. Manuf.

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Microfluidic devices are composed of microchannels with a diameter ranging in ten to a few hundred micrometers. Thus, quite small (10-9 to 10-18 litres) amount of liquid can be manipulated by such a precise system. In the past three decades, significant progresses in materials, microfabrication, and various applications have boosted the development of promising functional microfluidic devices. In this review, the recent progresses on novel microfluidic devices with various functions and applications are presented. First, the theory and numerical methods for studying the performance of microfluidic devices are briefly introduced. Then, materials, and fabrication methods of functional microfluidic devices are summarized. Next, from the viewpoint of the applications of the microfluidic devices, the recent significant advances in heat sink, clean water production, chemical reactions, sensor, biomedical field, capillaric circuits, flexible and wearable electronic devices, microrobotics, etc., in turns are then highlighted. Finally, personal perspectives on the challenges and future developments of functional microfluidic devices, aiming to motivate researchers from the fields of engineering, materials, chemistry, mathematics, physics, etc. working together to promote further development and applications of functional microfluidic devices, for the specific purpose of carbon neutrality are provided.

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Precision moulding of biomimetic disposable chips for droplet-based applications

Cited by 9 publications

References 48 publications

A Review of Current Methods in Microfluidic Device Fabrication and Future Commercialization Prospects

A Review of Current Methods in Microfluidic Device Fabrication and Future Commercialization Prospects

A Review of Cyclic Olefin Copolymer Applications in Microfluidics and Microdevices

Functional microfluidics: theory, microfabrication, and applications

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