Hemodialysis Membrane Coated with a Polymer Having a Hydrophilic Blood-Contacting Layer can Enhance Diffusional Performance

Tagaya, Masashi; Nagoshi, Saki; Matsuda, Morihiro; Takahashi, Shunsuke; Okano, S.; Hara, Kiyokazu

doi:10.5301/ijao.5000631

Cited by 10 publications

(5 citation statements)

References 30 publications

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“…To clarify the features of BPCA-coated hemofilters, we previously performed experiments to confirm that the BPCA coating did not disturb functions of diffusion and filtration and found that there is no malfunction of filtration and diffusion in BPCA-coated hemofilters. 8,9 Therefore, further investigation of BPCA-coated hemofilters to evaluate the antithrombotic effects is justified.…”

Section: Introductionmentioning

confidence: 99%

Antithrombotic properties of hemofilter coated with polymer having a hydrophilic blood-contacting layer

et al. 2018

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Objective:Extracorporeal circulation devices are coated with a biocompatible polymer coating agent (BPCA) that has a hydrophilic blood-contacting layer, but hemofilters are not. We aimed to investigate the antithrombotic properties of a BPCA-coated hemofilter.Methods:Four experiments using BPCA-coated circuits and non-coated hemofilters and four experiments using BPCA-coated circuits and BPCA-coated hemofilters were performed with whole human blood and compared by measuring the circuit pressure every 5 min, antithrombin activity every 40 min, and thrombin–antithrombin complex every 40 min, for a total of 240 min of recirculation.Results:The mean time required for the pressure at the inlet of the hemofilter to increase sharply was longer in BPCA-coated than in non-coated hemofilters (66 ± 11 min vs 25 ± 9 min, p < 0.01). The mean antithrombin activity value at 200 and 240 min of recirculation was significantly higher in the experiments with BPCA-coated versus non-coated hemofilters (43.3 ± 2.87 vs 33.3 ± 5.74, p = 0.04; 42.8 ± 3.59 vs 31.0 ± 5.35, p = 0.01, respectively); the antithrombin activity values at the other time points were not significantly different. Furthermore, all thrombin–antithrombin complex values in experiments with the BPCA-coated hemofilters achieved overrange at 80 min of recirculation, whereas those with the non-coated hemofilter achieved overrange at 40 min.Conclusion:This study suggests that BPCA-coated hemofilters can inhibit antithrombin consumption, contributing to antithrombotic effects in extracorporeal circulation circuits.

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Section: Introductionmentioning

confidence: 99%

Antithrombotic properties of hemofilter coated with polymer having a hydrophilic blood-contacting layer

et al. 2018

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“…Lysozyme has been used in several studies for assessing the sieving coefficient of low-molecular-weight protein in hemofilters consisting of synthetic polymer membranes; however, those studies required cancelling the adsorption effects. 11,22,23 Furthermore, it has been reported that a few blood cells could adhere to membrane surfaces. 24,25 However, with respect to the membrane oxygenator, several reports have suggested that ACP coating could neutralize cell adhesion and adsorption.…”

Section: Discussionmentioning

confidence: 99%

“…Following blood contact, the hydrophilic layer swells, thereby creating a water-filled boundary layer that maintains protein conformation and prevents surface activation. 9 To understand the effects of ACP coating on polymer membranes, we have previously assessed its influence on frictional stress of the membrane surface, diffusion rate, and antithrombin consumption and found that ACP coating reduces frictional stress, 10 enhances diffusion flux, 11 and inhibits antithrombin consumption. 12 However, while studying the diffusion rate, adsorption effects on the membrane surface might affect our results, thereby affecting the reliability of our findings.…”

Section: Introductionmentioning

confidence: 99%

Biocompatibility of a polymer-coated membrane possessing a hydrophilic blood-contacting layer: Adsorption-related assessment

et al. 2019

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Objective: Currently, the foreign surfaces of extracorporeal circulation devices are coated with an acrylate-based copolymer that creates a hydrophilic blood-contacting layer to enhance biocompatibility. Several reports of acrylate-based copolymer with respect to biocompatibility have been published; however, the adsorption of peptide compounds on acrylate-based copolymer–coated membranes still requires clarity. In this study, we aimed to understand the adsorption of several peptide compounds of various molecular weights, including albumin, lysozyme, and vancomycin, on acrylate-based copolymer–coated membranes using in vitro studies. Methods: Six experimental circuits consisting of acrylate-based copolymer–coated tubes and membranes, and six comprising acrylate-based copolymer–coated tubes and non-coated membranes were prepared for comparison. An experimental solution, composed of albumin, lysozyme, vancomycin, and saline, was continuously stirred in a reservoir, recirculated in each experimental circuit, and then filtered. Concentrations of albumin, lysozyme, and vancomycin were measured after 0, 15, 30, 45, 60, 90, and 120 min of recirculation. Similar experiments were performed in all the prepared circuits. Results: The ratio of measured values at each time point to those at 0 min was not significantly different between acrylate-based copolymer–coated and non-coated membranes for albumin and lysozyme, but differed significantly for vancomycin; the ratios were higher in acrylate-based copolymer–coated than in non-coated membranes. Conclusion: This study suggests that albumin is not adsorbed on either acrylate-based copolymer–coated or non-coated membranes, that lysozyme is not adsorbed on either membrane or is adsorbed at a similar rate on both membranes, and that vancomycin is less adsorbed on acrylate-based copolymer–coated membranes. Thus, acrylate-based copolymer coating could inhibit the adsorption of various peptide compounds.

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“…In the meantime, research that aims to explain the immunomodulatory pathogenesis of several critical illnesses will be helpful in order to better understand the role, the indications and the timing of HCO therapy. Future developments may include a sequential approach in which different therapeutic modalities, biomaterials and devices (45–52) can be used in sequence or in parallel with HCO membranes.…”

Section: Discussionmentioning

confidence: 99%

High Cut-off Membranes in Acute Kidney Injury and Continuous Renal Replacement Therapy

2017

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Innovation in continuous renal replacement therapies (CRRT) utilized to treat acute kidney injury (AKI) and sepsis, has brought new machines and techniques. Part of these new advances are due to the availability of innovative biomaterials and the construction of membranes with larger pores and wide distribution of pore sizes. This includes the creation of a new generation of high cut-off membranes whose utilization in clinical practice is promising for the wide spectrum of solutes that are removed during extracorporeal therapies.However, the enlargement of pore diameters brings some loss of albumin during treatment and this effect is still under evaluation, since there is a possibility that this is detrimental for the patient. A thorough review of the available clinical literature is reported in this paper with a reappraisal of the potential application of these new technologies.

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Hemodialysis Membrane Coated with a Polymer Having a Hydrophilic Blood-Contacting Layer can Enhance Diffusional Performance

Cited by 10 publications

References 30 publications

Antithrombotic properties of hemofilter coated with polymer having a hydrophilic blood-contacting layer

Antithrombotic properties of hemofilter coated with polymer having a hydrophilic blood-contacting layer

Biocompatibility of a polymer-coated membrane possessing a hydrophilic blood-contacting layer: Adsorption-related assessment

High Cut-off Membranes in Acute Kidney Injury and Continuous Renal Replacement Therapy

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