Hemocompatibility of Superhemophobic Titania Surfaces

Movafaghi, Sanli; Leszczak, Victoria; Wang, Wei; Sorkin, Jonathan A.; Dasi, Lakshmi Prasad; Popat, Ketul C.; Kota, Arun K.

doi:10.1002/adhm.201600717

Cited by 70 publications

(70 citation statements)

References 52 publications

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“…The solid surface energies were determined to be approximately 40 mN/m for Ti and NT, 11 mN/m for NT-S1, and 50 mN/m for NT-S2 through Owens-Wendt analysis, which are consistent with previously published data on titania nanotube arrays. [15,37,40]…”

Section: Resultsmentioning

confidence: 99%

“…[6] The adhered bacteria were fixed using a process described elsewhere. [40,41] In brief, the surfaces were soaked in a primary fixative made of 0.1 M sucrose, 0.1 M sodium cacodylate, and 3% glutaraldehyde (v/v) in DI water for 45 mins. The surfaces were then moved to the secondary fixative composed of 0.1 M sucrose and 0.1 M sodium cacodylate in DI water.…”

Section: Methodsmentioning

confidence: 99%

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Antibacterial activity on superhydrophobic titania nanotube arrays

Bartlet

Movafaghi

Dasi

et al. 2018

Colloids and Surfaces B: Biointerfaces

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Bacterial infections are a serious issue for many implanted medical devices. Infections occur when bacteria colonize the surface of an implant and form a biofilm, a barrier which protects the bacterial colony from antibiotic treatments. Further, the anti-bacterial treatments must also be tailored to the specific bacteria that is causing the infection. The inherent protection of bacteria in the biofilm, differences in bacteria species (gram-positive vs. gram-negative), and the rise of antibiotic-resistant strains of bacteria makes device-acquired infections difficult to treat. Recent research has focused on reducing biofilm formation on medical devices by modifying implant surfaces. Proposed methods have included antibacterial surface coatings, release of antibacterial drugs from surfaces, and materials which promote the adhesion of non-pathogenic bacteria. However, no approach has proven successful in repelling both gram-positive and gram-negative bacteria. In this study, we have evaluated the ability of superhydrophobic surfaces to reduce bacteria adhesion regardless of whether the bacteria are gram-positive or gram-negative. Although superhydrophobic surfaces did not repel bacteria completely, they had minimal bacteria attached after 24 h and more importantly no biofilm formation was observed.

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Section: Resultsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Antibacterial activity on superhydrophobic titania nanotube arrays

Bartlet

Movafaghi

Dasi

et al. 2018

Colloids and Surfaces B: Biointerfaces

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“…Hence, platelet adhesion can be reduced by limiting the effective area available to platelets (Figure a). One way to limit the effective area is to utilize a superhydrophobic surface in the Cassie state . Movafaghi et al showed that superhydrophobic titania nanotubes reduce the number of adherent platelets by up to 67% compared to nontextured surfaces, which was explained by a stable Cassie state leading to a smaller effective area.…”

Section: Micro‐ and Nanostructure‐induced Blood‐repellencymentioning

confidence: 99%

Superhydrophobic Blood‐Repellent Surfaces

et al. 2018

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Superhydrophobic surfaces repel water and, in some cases, other liquids as well. The repellency is caused by topographical features at the nano-/microscale and low surface energy. Blood is a challenging liquid to repel due to its high propensity for activation of intrinsic hemostatic mechanisms, induction of coagulation, and platelet activation upon contact with foreign surfaces. Imbalanced activation of coagulation drives thrombogenesis or formation of blood clots that can occlude the blood flow either on-site or further downstream as emboli, exposing tissues to ischemia and infarction. Blood-repellent superhydrophobic surfaces aim toward reducing the thrombogenicity of surfaces of blood-contacting devices and implants. Several mechanisms that lead to blood repellency are proposed, focusing mainly on platelet antiadhesion. Structured surfaces can: (i) reduce the effective area exposed to platelets, (ii) reduce the adhesion area available to individual platelets, (iii) cause hydrodynamic effects that reduce platelet adhesion, and (iv) reduce or alter protein adsorption in a way that is not conducive to thrombus formation. These mechanisms benefit from the superhydrophobic Cassie state, in which a thin layer of air is trapped between the solid surface and the liquid. The connections between water- and blood repellency are discussed and several recent examples of blood-repellent superhydrophobic surfaces are highlighted.

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“…[39,42,43] Superhydrophobic surfaces can be systematically designed by combining low solid surface energy with appropriate microscale or nanoscale texture. [44][45][46][47][48][49][50][51][52] While textured superhydrophobic surfaces can prevent the accumulation of water and help retain the dielectric strength of insulators under wet conditions, the presence of texture reduces the dielectric strength due to the accumulation of charge on sharp features. [53][54][55] In this work, we investigated whether or not textured superhydrophobic surfaces can retain the dielectric strength under wet conditions.…”

Section: Superhydrophobic Insulatorsmentioning

confidence: 99%

“…A surface is considered to be superhydrophobic if it displays θ * > 150° and Δθ * < 10° with water . Superhydrophobic surfaces can be systematically designed by combining low solid surface energy with appropriate microscale or nanoscale texture …”

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confidence: 99%

Superhydrophobic Coatings for Improved Performance of Electrical Insulators

Vallabhuneni

Movafaghi

Wang

et al. 2018

Macro Materials & Eng

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Dielectric strength of electrical insulators is adversely affected by both wet conditions and surface roughness due to accelerated dielectric breakdown. While textured superhydrophobic coatings (i.e., coatings that are extremely repellent to water) can prevent the accumulation of water and help retain the dielectric strength of insulators under wet conditions, it is unclear whether or not the presence of texture (i.e., surface roughness) allows the retention of the dielectric strength of insulators. In this work, through a series of systematic experiments and analysis, it is concluded that porous superhydrophobic coatings rather than rough monolithic superhydrophobic surfaces allow the retention of dielectric strength of insulators under wet conditions in spite of the surface roughness. The insights from this work can enable the design of electrical insulators with improved performance and increased longevity.

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Hemocompatibility of Superhemophobic Titania Surfaces

Cited by 70 publications

References 52 publications

Antibacterial activity on superhydrophobic titania nanotube arrays

Antibacterial activity on superhydrophobic titania nanotube arrays

Superhydrophobic Blood‐Repellent Surfaces

Superhydrophobic Coatings for Improved Performance of Electrical Insulators

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