Hemocompatibility Multi-in-One Hydrogel Coating with ROS-Triggered Inflammation Suppression and Anti-Infection Properties for Blood-Contacting Device

Abstract

In traditional blood-contacting medical devices, infection and thrombosis are easily formed on the surface of the materials. In addition, inflammation is also a clinical complication that cannot be ignored. More importantly, there is a mutually promoting relationship between the inflammatory response and the infection as well as thrombosis. In this work, we propose a self-adaptive antiinflammatory coating strategy combined with anti-infection and anticoagulant capacity, which was accomplished based on nano-Ag particles and dexamethasone (Dex)-loaded hydrogel coating. The coating loaded with nano-Ag endows it with good bactericidal performance, including Gram-positive and Gram-negative bacteria. As an anti-inflammatory drug, Dex was grafted onto hydrogel coating by a reactive oxygen species (ROS)-cleavable thioketal (TK) bond and released upon the trigger of an inflammatory environment, blocking further inflammatory cascade, providing self-adaptive antiinflammatory properties, and avoiding side effects of the drug. It was demonstrated that the coating worked as a precise strategy to resist coagulation, infection, and inflammation, provided a new perspective for designing clinical complication-conformable coatings, and had great application prospects on blood-contacting medical devices.

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“…Blood-contacting materials have revolutionized the method of clinical diagnosis and treatment, proving instrumental in saving innumerable lives across various acute and chronic diseases. [1,2] Polyurethane (PU) is a common material used for repairing DOI: 10.1002/adhm.202400126 defects in artificial organs and implants, such as artificial heart valves, artificial blood vessels, and implant materials. [3] Previous studies have shown that although PU has good compliance, the microphase separation structure between its surface hard segments and soft segments could cause differences in surface energy, with the soft segments of PU being more prone to platelet adhesion.…”