Hemocompatibility, biocompatibility, inflammatory and <i>in vivo</i> studies of primary reference materials low‐density polyethylene and polydimethylsiloxane: A review

Bélanger, Marie‐Claire; Marois, Yves

doi:10.1002/jbm.1043

Cited by 421 publications

(286 citation statements)

References 32 publications

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“…The optical sensor performance (sensitivity, resolution) is comparable to recently published sensors of a similar nature, 8,11,12 with a simpler fabrication protocol and a more flexible platform for detection of gaseous or dissolved oxygen. The compactness, demonstrated biocompatibility of the PDMS material, 26 and rapid, inexpensive fabrication capability of the device make it ideally suited to a range of biological applications in various configurations. Foreseeable applications include tissue engineering and cell culturing in a microfluidic environment, real-time blood gas detection in a clinical environment, or extracorporeal oxygenation in a surgical setting.…”

Section: Discussionmentioning

confidence: 99%

Development of an integrated microfluidic platform for dynamic oxygen sensing and delivery in a flowing medium

et al. 2005

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This paper describes a platform for real-time sensing of dissolved oxygen in a flowing microfluidic environment using an oxygen-sensitive luminescent dye (platinum octaethylporphyrin ketone) integrated into a micro-oxygenator device. Using a phase-based detection method, the luminescent decay lifetime of the dye was consistent with the linear Stern-Volmer relationship using both gaseous and aqueous samples. Maximum sensor resolution varied between 120-780 ppb across a range of dissolved oxygen (DO) concentrations ranging from 0-42.5 ppm. The sensor was subsequently used to determine the convective mass-transfer characteristics of a multilayer polydimethylsiloxane (PDMS) microfluidic oxygenator. The membrane-based oxygenator showed excellent agreement with an analytical convection model, and the integrated oxygen sensor was accurate across a wide range of tested flow rates (0.05-5 mL min 21). The device is unique for its ease of fabrication and highly flexible configuration, as well as the novel incorporation of oxygen delivery and detection in a single micro-device. Potential applications include tissue engineering, cell culturing, and miniaturized bio-assays that require the delivery and/or detection of precise quantities of oxygen within a microfluidic construct.

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Section: Discussionmentioning

confidence: 99%

Development of an integrated microfluidic platform for dynamic oxygen sensing and delivery in a flowing medium

et al. 2005

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“…Films and pallets were fabricated in a manner similar to that previously described. 29-31 SU-8 films with different thickness (10,25,50,75, and 100 μm) were obtained by spin-coating SU-8 photoresist on glass slides following the protocol provided by MicroChem Corp. 1,33,34…”

Section: Fabrication Of Films and Pallets From Su-8 Or 1002f Photoresistmentioning

confidence: 99%

Photoresist with Low Fluorescence for Bioanalytical Applications

et al. 2007

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The negative photoresist SU-8 has found widespread use as a material in the fabrication of microelectrical-mechanical systems (MEMS). While SU-8 has been utilized as a structural material for biological MEMS, a number of SU-8 properties limit its application in these bioanalytical devices. These attributes include its brittleness, nonspecific adsorption of biomolecules, and high fluorescence in the visible wavelengths. In addition, native SU-8 is a poor substrate for cellular adhesion. Photoresists composed of resins with epoxide side groups and photoacids were screened for their ability to serve as a low fluorescence photoresist with sufficient resolution to generate microstructures with dimensions of 5-10 μm. The fluorescence of structures formed from 1002F photoresist (1002F resin combined with triarylsulfonium hexafluoroantimonate salts) was as much as 10 times less fluorescent than similar SU-8 microstructures. The absorbance of 1002F in the visible wavelengths was also substantially lower than that of SU-8. Microstructures or pallets with an aspect ratio as high as 4:1 could be formed permitting 1002F to be used as a structural material in the fabrication of arrays of pallets for sorting adherent cells. Several different cell types were able to adhere to native 1002F surfaces and the viability of these cells was excellent. As with SU-8, 1002F has a weak adhesion to glass, a favorable attribute when the pallet arrays are used to sort adherent cells. A threshold, laserpulse energy of 3.5 μJ was required to release individual 50-μm, 1002F pallets from an array. Relative to SU-8, 1002F photoresist offers substantial improvements as a substrate in bioanalytical devices and is likely to find widespread use in BioMEMS.

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“…PDMS is a widely used material for fabricating lFDs (Gong and Wen 2009;Zhou et al 2010;Vullev et al 2006; Thomas et al 2010a). Despite its shortcomings, such as porosity (Li et al 2009;Mehta et al 2009;Chueh et al 2007;Shin et al 2003) and susceptibility to a broad range of organic solvents (Lee et al 2003), PDMS is biocompatible (Belanger and Marois 2001;Zhuang et al 2007) and allows for expedient and facile reproduction of features with nanometer precision that are essential for lFDs (Gates 2005;Cong and Pan 2008).…”

Section: Introductionmentioning

confidence: 99%

Dependence of the quality of adhesion between poly(dimethylsiloxane) and glass surfaces on the composition of the oxidizing plasma

Chau

Millare

Lin

et al. 2010

Microfluid Nanofluid

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Controlled surface oxidation of polydimethylsiloxane (PDMS) is essential for permanent adhesion between device components composed of this elastomer. The permanent adhesion between such microdevice components results from covalent crosslinking across the interfaces between PDMS and other silica-based materials, such as glass, quartz, and PDMS. Optimal duration and conditions of oxidation, attained via treatments with oxygen-containing plasma, are crucial for microfabrication procedures with quantitative yields. While insufficient PDMS oxidation does not provide high enough surface density of siloxyl groups for cross-interface linking, overoxidation of PDMS yields rough silica surface layers that prevent the adhesion between flat substrates. Ideally, for a set of plasma conditions, the range of treatment durations producing permanent adhesion should be as broad as possible: i.e., the surface oxidation of PDMS sufficient for irreversible binding has to complete significantly before the effects of overoxidation become apparent. Such a requirement assures that relatively small fluctuations in the treatment conditions will not result in over-or under-oxidation and, hence, will not compromise the yields of the fabrication procedures. We examined the dependence of the quality of adhesion (QA) between plasma-treated PDMS and glass substrates on the composition of the oxygen-containing plasma and on the radio frequency (RF) of the plasma generator. We observed that plasma generated at megahertz RF provided superior conditions than kilohertz RF. Concurrently, an increase in the oxygen content of binary gas mixtures, used for the plasma, broadened the treatment durations that afford superior QA.

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Hemocompatibility, biocompatibility, inflammatory and in vivo studies of primary reference materials low‐density polyethylene and polydimethylsiloxane: A review

Cited by 421 publications

References 32 publications

Development of an integrated microfluidic platform for dynamic oxygen sensing and delivery in a flowing medium

Development of an integrated microfluidic platform for dynamic oxygen sensing and delivery in a flowing medium

Photoresist with Low Fluorescence for Bioanalytical Applications

Dependence of the quality of adhesion between poly(dimethylsiloxane) and glass surfaces on the composition of the oxidizing plasma

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