Hemocompatibility and anti-biofouling property improvement of poly(ethylene terephthalate) via self-polymerization of dopamine and covalent graft of zwitterionic cysteine

Li, Pengfei; Cai, Xianmei; Wang, Ding; Chen, Shuangchun; Yuan, Jiang; Li, Li; Shen, Jing

doi:10.1016/j.colsurfb.2013.04.044

Cited by 64 publications

(42 citation statements)

References 33 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…As a natural zwitterion polymer, cysteine is an available material for its characteristics of low‐cost, widespread and easily biosynthesized. Shen et al covalently grafted cysteine onto the PET sheets in order to increase blood compatibility and anti‐biofouling performance of the membranes . Shao et al immobilized cysteine onto PEG polymerized by surface‐wave plasma .…”

Section: Introductionmentioning

confidence: 99%

Polydopamine/cysteine surface modified hemocompatible poly(vinylidene fluoride) hollow fiber membranes for hemodialysis

Dai

Wei

et al. 2018

J Biomed Mater Res

View full text Add to dashboard Cite

Membrane surface design is significant for the development and application of synthetic polymer hemodialysis membranes. In this study, the influence of zwitterionic cysteine on poly(vinylidene fluoride) (PVDF) hollow fiber membrane was investigated. The polydopamine layer was formed through dopamine self-polymerization on PVDF membrane surface, and then cysteine was covalent grafted onto the layer to improve the anti-biofouling property and hemocompatibility. The elementary composition of membrane surfaces was characterized by X-ray photoelectron spectroscopy. The influence of polydopamine and cysteine on modified membrane surface morphologies was studied by field emission scanning electron microscopy. The modified PVDF membranes were confirmed to have excellent hydrophilicity, stable mechanical properties and good hemocompatibility (dynamic and static anti-protein adsorption, hemolysis ratio, plasma coagulation). And these properties were increased with the incorporation of polydopamine and cysteine. The optimized modified membranes exhibited high pure water flux (∼ 195.5 L/m h at 0.1 MPa) and selectivity (clearance ratio of urea and lysozyme was 75.1 and 55.4%, and rejection rate of bovine serum albumin was 98.8%). This work provides a surface modification method of PVDF hollow fiber membranes and suggests a potential application of PVDF membranes in hemodialysis field. © 2018 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater, 106B: 2869-2877, 2018.

show abstract

Section: Introductionmentioning

confidence: 99%

Polydopamine/cysteine surface modified hemocompatible poly(vinylidene fluoride) hollow fiber membranes for hemodialysis

Dai

Wei

et al. 2018

J Biomed Mater Res

View full text Add to dashboard Cite

show abstract

“…The improvement of cellular and biological fluids interactions with medical devices is a major issue in biomaterials science, especially in the case of blood contact, where the use of inappropriate surface materials may cause cardiovascular complications such as thrombus formation and blood platelet adhesion …”

Section: Discussionmentioning

confidence: 99%

In vitro and in vivo hemocompatibility evaluation of a new dermatan sulfate-modified PET patch for vascular repair surgery

Dhahri

Rodriguez-Ruiz

Aid‐Launais

et al. 2016

J. Biomed. Mater. Res.

View full text Add to dashboard Cite

The development of new vascular devices requires to study the effects of materials on blood cells and on coagulation, both in vitro and in vivo. In this study, we have developed a new material by grafting dermatan sulfate (DS) from shark skin onto polyethylene terephthalate (PET). We have evaluated the haemocompatibility of PET-DS material in vitro by measuring thrombin generation, plasma recalcification time, hemolytic activity, and platelet adhesion and in vivo with a model of vascular patch in rat abdominal aorta. In vitro, our results have shown that PET-DS is a nonhemolytic material, able to inhibit thrombin generation and platelet adhesion. In vivo studies by Doppler echographic evaluation 20 days after implantation have shown that the PET-DS patch was integrated in the vessel wall and covered by a layer of cells. In conclusion, PET-DS has good haemocompatibility properties and could be a promising tool for vascular surgery. © 2016 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater, 105B: 2001-2009, 2017.

show abstract

“…It is thus promising candidates for hemodialysis and hemapheresis . However, the intrinsic hydrophobicity of PVDF can easily lead to protein adsorption, activation of the coagulation sequence, thrombus formation and other complications on the membrane surface, which makes it a necessary method to modify PVDF membrane to overcome such shortcoming and take advantage of the excellent bulk properties of PVDF for practical uses …”

Section: Introductionmentioning

confidence: 99%

Dual functionalized poly(vinylidene fluoride) membrane with acryloylmorpholine and argatroban to improve antifouling and hemocompatibility

Feng

et al. 2016

J Biomedical Materials Res

View full text Add to dashboard Cite

The present work aims to improve the antifouling properties and anticoagulation of poly(vinylidene fluoride) (PVDF) membrane by dual modification. An amphiphilic copolymer of PVDF-g-(polyacryloylmorpholine-(polyacrylic acid)) [PVDF-g-(PACMO-PAA)] was first prepared by the free radical copolymerization. Then argatroban, a commonly used anticoagulant, was successfully grafted to PVDF-g-(PACMO-PAA). Finally the obtained copolymer was casted into a flat membrane via immersion phase inversion. The as-prepared copolymer membranes show improved hydrophilicity, higher water flux and lower protein adsorption. Moreover, the hemolysis and coagulation tests for the dual functionalized PVDF membrane exhibit decreased hemolysis ratio, with prolonged plasma recalcification time, activated partial thromboplastin time and thrombin time. PVDF membrane incorporating PACMO and AG reveals an improved hemocompatibility, which has a good potential to be used in blood purification. © 2016 Wiley Periodicals, Inc. J Biomed Mater Res Part A: 105A: 178-188, 2017.

show abstract

Hemocompatibility and anti-biofouling property improvement of poly(ethylene terephthalate) via self-polymerization of dopamine and covalent graft of zwitterionic cysteine

Cited by 64 publications

References 33 publications

Polydopamine/cysteine surface modified hemocompatible poly(vinylidene fluoride) hollow fiber membranes for hemodialysis

Polydopamine/cysteine surface modified hemocompatible poly(vinylidene fluoride) hollow fiber membranes for hemodialysis

In vitro and in vivo hemocompatibility evaluation of a new dermatan sulfate-modified PET patch for vascular repair surgery

Dual functionalized poly(vinylidene fluoride) membrane with acryloylmorpholine and argatroban to improve antifouling and hemocompatibility

Contact Info

Product

Resources

About