Hemispheric functional segregation facilitates target detection during sustained visuospatial attention

DiNuzzo, Mauro; Mascali, Daniele; Bussu, Giorgia; Moraschi, Marta; Guidi, María; Macaluso, Emiliano; Mangia, Silvia; Giove, Federico

doi:10.1002/hbm.25970

Cited by 6 publications

(2 citation statements)

References 71 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…There is evidence of enhanced intrahemispheric functional connectivity of AN in the right hemisphere in BD patients [12,[54][55][56], accompanied by similar findings in structural connectivity [57,58]. The AN in the right hemisphere tends to play an important role in spatial attention and executive control, which may reflect a compensatory mechanism for related functions [59][60][61]. We found that the triggers of MLI changes were different in the AN of the bilateral hemispheres, and some studies [62,63] have pointed out the asymmetry of the AN itself.…”

Section: The Increased MLI Of An In the Right Hemisphere Is Caused By...mentioning

confidence: 81%

Enhanced Dynamic Laterality Based on Functional Subnetworks in Patients with Bipolar Disorder

Li,

Hao,

Hao

et al. 2023

Brain Sciences

View full text Add to dashboard Cite

An ocean of studies have pointed to abnormal brain laterality changes in patients with bipolar disorder (BD). Determining the altered brain lateralization will help us to explore the pathogenesis of BD. Our study will fill the gap in the study of the dynamic changes of brain laterality in BD patients and thus provide new insights into BD research. In this work, we used fMRI data from 48 BD patients and 48 normal controls (NC). We constructed the dynamic laterality time series by extracting the dynamic laterality index (DLI) at each sliding window. We then used k-means clustering to partition the laterality states and the Arenas–Fernandez–Gomez (AFG) community detection algorithm to determine the number of states. We characterized subjects’ laterality characteristics using the mean laterality index (MLI) and laterality fluctuation (LF). Compared with NC, in all windows and state 1, BD patients showed higher MLI in the attention network (AN) of the right hemisphere, and AN in the left hemisphere showed more frequent laterality fluctuations. AN in the left hemisphere of BD patients showed higher MLI in all windows and state 3 compared to NC. In addition, in the AN of the right hemisphere in state 1, higher MLI in BD patients was significantly associated with patient symptoms. Our study provides new insights into the understanding of BD neuropathology in terms of brain dynamic laterality.

show abstract

Section: The Increased MLI Of An In the Right Hemisphere Is Caused By...mentioning

confidence: 81%

Enhanced Dynamic Laterality Based on Functional Subnetworks in Patients with Bipolar Disorder

Li,

Hao,

Hao

et al. 2023

Brain Sciences

View full text Add to dashboard Cite

show abstract

“…The literature suggests that drawing asymmetries, which can be a manifestation of attentional and directional biases, are a consequence of a complex interaction between biological, motoric, and cultural factors (DiNuzzo et al, 2022;. The asymmetries observed in graphomotor productions such as drawing may reflect the implication of cerebral lateralization (i.e., right hemisphere dominance for visuospatial attention), biomechanical (i.e., the ease for outward oriented motor movements) and cultural factors (i.e., script directionality).…”

Section: Discussionmentioning

confidence: 99%

Development of laterality: Asymmetrical human behaviors and perceptual biases

Hamaoui¹

2022

Preprint

View full text Add to dashboard Cite

Many asymmetries characterize human functioning at the behavioral level, such as handedness (right-handedness, left-handedness, mixed-handedness) and the cerebral level. Atypical laterality is frequently mentioned in scientific literature as part of the clinical picture of several neurodevelopmental and psychiatric disorders. Thus, understanding the neurodevelopmental mechanisms underlying laterality could shed light on the etiology of cognitive and motor difficulties. The goal of this thesis is twofold. Firstly, the theoretical objective was to investigate the involvement of the prenatal environment in the development of handedness. The influence of the vestibular system, fetal presentation, and other perinatal factors related to pregnancy complications and birth stressors were tested. Our results show no influence of the fetal presentation on the subsequent development of handedness. Perinatal adversities such as prematurity, low birthweight, and poor neonatal health reflected by very low Apgar scores however, appear to be risk factors which increase the prevalence of atypical handedness and motor impairments. Secondly, the applied objective was to simultaneously detect the different perceptual biases implicated in graphomotor productions. A 3D-2D transcription graphic task was proposed for identifying global patterns of drawing asymmetries, underpinned by cerebral lateralization, biomechanical constraints, and sociocultural influences. Our results suggest that cerebral lateralization, modulated by handedness and sex, influence graphomotor asymmetries in both children and adults. However, this influence is weaker in adults, which could be due to sociocultural influences.

show abstract

Hemispheric functional segregation facilitates target detection during sustained visuospatial attention

DiNuzzo

Mascali

Bussu

et al. 2022

Human Brain Mapping

Self Cite

View full text Add to dashboard Cite

Visuospatial attention is strongly lateralized, with the right hemisphere commonly exhibiting stronger activation and connectivity patterns than the left hemisphere during attentive processes. However, whether such asymmetry influences inter‐hemispheric information transfer and behavioral performance is not known. Here we used a region of interest (ROI) and network‐based approach to determine steady‐state fMRI functional connectivity (FC) in the whole cerebral cortex during a leftward/rightward covert visuospatial attention task. We found that the global FC topology between either ROIs or networks was independent on the attended side. The side of attention significantly modulated FC strength between brain networks, with leftward attention primarily involving the connections of the right visual network with dorsal and ventral attention networks in both the left and right hemisphere. High hemispheric functional segregation significantly correlated with faster target detection response times (i.e., better performance). Our findings suggest that the dominance of the right hemisphere in visuospatial attention is associated with an hemispheric functional segregation that is beneficial for behavioral performance.

show abstract

Hemispheric functional segregation facilitates target detection during sustained visuospatial attention

Cited by 6 publications

References 71 publications

Enhanced Dynamic Laterality Based on Functional Subnetworks in Patients with Bipolar Disorder

Enhanced Dynamic Laterality Based on Functional Subnetworks in Patients with Bipolar Disorder

Development of laterality: Asymmetrical human behaviors and perceptual biases

Hemispheric functional segregation facilitates target detection during sustained visuospatial attention

Contact Info

Product

Resources

About