Hemiretinal stimuli elicit different amplitudes in the pattern electroretinogram

Abstract

Pattern electroretinograms were elicited in 13 normal eyes by half-field checkerboard stimulation of nasal-temporal and upper-lower retinal areas. With nasal-temporal visual half-field stimulation the p-q component amplitude of the nasal hemiretina was significantly larger than that of the temporal hemiretina. With upper-lower visual half-field stimulation the amplitude was significantly larger for the upper than for the lower hemiretina. No significant differences were found with respect to the component latency. Finding the p-q amplitude of the pattern electroretinogram to be closely related to the distribution of nerve cells in the innermost retinal layer supports the conclusion that the pattern response is generated in the more proximal retinal layers including the retinal ganglion cells.

Effect of Hemifield Stimulation on Simultaneous Steady-State Pattern Reversal Electroretinogram and Visual Evoked Response

“…Bopp [31] found that the PERG amplitude in response to temporal hemifield stimulation was 33% larger than in response to stimuli applied to the nasal hemifield. Yoshii and Paarman [32] reported similar results, that PERG elicited by temporal hemifield stimu lation was 24 and 27% larger with both the 30-and 60-min check sizes, and speculated that this asymmetry was related to the distri bution of the retinal ganglion cells. Miyake et al [33], using the flash focal ERG, did not find significant differences in a-and b-wave amplitudes between the nasal/temporal hemimacular stimulations.…”

“…Regarding the presence or absence of hori zontal asymmetry reported by Bopp [31 ], Yo shii and Paarman [32] and Miyake et al…”

“…Several important studies on the asymmetry of electrophysiologic responses between the hemiretinal stim ulations have been undertaken using PVER [26][27][28][29][30], PERG [27,31,32], focal flash ERG [33], and electro-oculogram (EOG) [34]. A direct comparison of PVER and PERG in these specific stimulus conditions has been reported only by Groneberg [27], In this study, we investigated the effect of both upper/lower and nasal/temporal hemiretinal stimulation on the PERG/PVER amplitudes at two levels of contrast.…”

Senescence of human multifocal electroretinogram components: a localized approach

“…Nagamoto et al [39] (using lower mean luminance and fewer stimulating areas) demonstrated larger N1P1 mfERG amplitude in the upper retina, but they did not estimate the effect of age. Similarly, higher amplitudes of the pattern ERG were obtained from stimulation of the upper hemiretina [61]. Regional differences of neuronal cell distribution such as has been shown for rod photoreceptor [29,59] and ganglion cell [9,11] density, along with differential rates of agerelated change, could have an influence on the mfERG signal.…”

Nonlinear Component of the Electroretinogram Recorded from the Posterior Pole of Normal and Highly Myopic Human Eyes

“…The half-field pattern ERG studies have confirmed this concept, in that the sum of two halves is slightly greater than the full-field response [3,4]. A satisfactory account of visual perception demands consideration of the visual system as a nonlinear system [5].…”