Effect of Hemifield Stimulation on Simultaneous Steady-State Pattern Reversal Electroretinogram and Visual Evoked Response

Katsumi, Osamu; Tetsuka, Soichi; Mehta, Manisha; Tetsuka, Hitomi; Hirose, Tatsuo

doi:10.1159/000267274

Cited by 8 publications

(1 citation statement)

References 17 publications

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“…However, it appears that this increase does not begin until contrast exceeds 1 -20% (Hess & Baker, 1984). This effect of contrast does not seem to hold when hemifield stimuli are compared, regardless of whether they are nasal/temporal or superior/inferior (Katsumi, Tetsuka, Mehta, Tetsuka, & Hirose, 1993), though further investigation will be necessary to confirm this. Since the relationship between the standard PERG and contrast is so robust, it is imperative to maximize stimulus contrast so that the already-small response amplitude can be maximized, as well.…”

Section: Contrastmentioning

confidence: 90%

Impact of luminance and spatial parameters on the generation of the human pattern electroretinogram.

Godwin¹

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who were pivotal in applying this research to the glaucoma population. This particular effort was also aided by the entire staff of the Kentucky Lions Eye Center, to whom I am also indebted. Dr. Jonathan Nussdorf acted as an additional resource for understanding this patient population, and I am appreciative of the time and expertise he offered in planning the design of the third experiment. I am also grateful for the assistance of Dr. Thomas Roussel, who so graciously offered his time and knowledge to improve the programs written for these experiments and decrease the electrical noise of the recording area. Further, I wish to thank both past and current lab mates, Pan Shi and Eleanor O'Keefe, for their support, encouragement, and friendship. Finally, I would also like to extend my thanks to all participants of this study for making this research possible.

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Section: Contrastmentioning

confidence: 90%

Impact of luminance and spatial parameters on the generation of the human pattern electroretinogram.

Godwin¹

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Objective Perimetry in Glaucoma

Graham¹,

Klistorner²,

Grigg³

et al. 1999

Survey of Ophthalmology

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Retinal ganglion cell dysfunction in humans following post-geniculate lesions: specific spatio–temporal losses revealed by pattern ERG

Porrello

Falsini

1999

Vision Research

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Nasal and temporal hemifield (14 x 24 degrees) pattern electroretinograms (PERGs) were recorded in eight patients (age range: 21-72 years) suffering from different post-geniculate lesions (documented by CT scan and/or MRI of the brain) and homonymous hemianopia at visual field testing. In total eight age-matched normal subjects served as controls. PERGs were elicited by alternating, sinusoidal gratings (90% contrast), whose spatial and temporal characteristics, 6 Hz-5 c deg-1 and 15 Hz-0.58 c deg-1, were chosen to enhance the relative contributions of parvo- (P) and magno- (M) retinal ganglion cell (GC) subsystems, respectively. Amplitudes and phases of the Fourier analyzed PERG 2nd harmonics were measured. In normal subjects, PERG amplitudes to 15 Hz-0.58 c deg-1, but not those of the 6 Hz-5 c deg-1 stimuli were on average larger (P < 0.05) in nasal than in temporal hemiretinae. In hemianopic patients, PERG amplitudes of 6 Hz-5 c deg-1 stimuli were on average reduced (P < 0.05) in the hemiretinae corresponding to blind hemifields, in comparison to those in the hemiretinae corresponding to functional hemifields. No differences between hemiretinae were observed for responses of the 15 Hz-0.58 c deg-1 stimuli. In both normal subjects and patients, average PERG phases did not differ between hemiretinae, while changing significantly (P < 0.01) across stimulus conditions. The PERG naso-temporal asymmetries observed in normal subjects are consistent with the reported asymmetries in GC density observed histologically (Curcio & Allen. (1990). Journal of Comparative Neurology, 300, 5-25). The results in patients indicate that the PERGs to specific spatio-temporal stimuli (i.e. of relatively low-temporal and high-spatial frequency), presented in the hemianopic field, are reduced in amplitude. This suggests, in agreement with the experimental findings in monkeys (Cowey & Stoerig. (1991). Trends in Neuroscience, 14, 140-145), that retrograde trans-synaptic dysfunction of P-GCs, with relative sparing of the M-subsystem, may occur in humans following lesions of post-geniculate pathways.

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Effect of Hemifield Stimulation on Simultaneous Steady-State Pattern Reversal Electroretinogram and Visual Evoked Response

Cited by 8 publications

References 17 publications

Impact of luminance and spatial parameters on the generation of the human pattern electroretinogram.

Impact of luminance and spatial parameters on the generation of the human pattern electroretinogram.

Objective Perimetry in Glaucoma

Retinal ganglion cell dysfunction in humans following post-geniculate lesions: specific spatio–temporal losses revealed by pattern ERG

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