Heme oxygenase-1 mediates cytoprotection against nitric oxide-induced cytotoxicity via the cGMP pathway in human pulp cells

The role of heme oxygenase-1 in mechanical stress- and lipopolysaccharide-induced osteogenic differentiation in human periodontal ligament cells

“…[19][20][21][22][23][24] In the present study, we found that MS increased HO-1 mRNA and protein expression in PDLCs. These findings are consistent with our previous study in which osteogenic differentiation Figure 4.…”

“…Previously, we reported that the HO-1 pathway is a key mechanism for the adaptation to stressful conditions and the recovery from injurious events by dental cells. [19][20][21][22][23][24] Moreover, the expression of HO-1 is related to adipogenesis by human MSCs, 25 osteoblastic differentiation by PDLCs 23 and neuronal differentiation by MSCs. 26 Because HO-1 is associated with differentiation, it is plausible to postulate that HO-1 is involved in the response of PDLCs to MS and bacterial infection as well as in the differentiation of PDLCs to osteoblast-like cells.…”

Anti-inflammatory effects of apigenin on nicotine- and lipopolysaccharide-stimulated human periodontal ligament cells via heme oxygenase-1

“…Previously, we reported that the HO-1 pathway is a key mechanism for both the adaptation of cells to stressful conditions and their recovery from injurious events in human pulp and PDL cells [27][28][29][30][31][32]. Moreover, HO-1 has therapeutic potential in hepatoprotection [33], inflammatory arthritis [34], psoriasiform skin lesions [35], neuroinflammation [36], inflammatory bowel disease [37], and periodontitis [15].…”

The Role of Heme Oxygenase-1 in the Proliferation and Odontoblastic Differentiation of Human Dental Pulp Cells

“…Previously, we reported that the HO-1 pathway plays a key role in the adaptation of cells to stressful conditions and the recovery of HDPCs and periodontal ligament cells (PDLCs) from injurious events (7)(8)(9)(10)(11)(12). Moreover, several studies have shown that HO-1 expression is related to adipogenesis in human mesenchymal stem cells (MSCs) (13), osteoblastic differentiation in PDLCs (7,12), and neuronal differentiation in MSCs (14).…”