Heme Oxygenase-1/Ferritin in Protection of Leukemia Cells from Oxidative Stress Induced by Catalytic System “Teraphtal + Ascorbic Acid”

Sidorova, T. A.; Ryabaya, O. O.; Prokof’eva, AA; Хоченков, Д А

doi:10.21320/2500-2139-2019-12-4-416-427

Cited by 3 publications

(2 citation statements)

References 76 publications

(61 reference statements)

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“…We have to mention the sodium salt of cobalt 4,5-carboxyphthalocyanine, so-called “Terafthal” (TF). − The combination of Asc and TF failed phase II clinical trials in Russia. However, researchers are developing strategies to improve the therapeutic effectiveness and TF application in other fields . Sidorova and colleagues reported two times enhanced cytotoxic activity and increased ROS generation in K562/4 cells (doxorubicin resistant) after TF/Asc in combination with catalase inhibitor (3-aminotriazole) treatment .…”

Section: Therapymentioning

confidence: 99%

“…However, researchers are developing strategies to improve the therapeutic effectiveness and TF application in other fields . Sidorova and colleagues reported two times enhanced cytotoxic activity and increased ROS generation in K562/4 cells (doxorubicin resistant) after TF/Asc in combination with catalase inhibitor (3-aminotriazole) treatment . The same research group noticed K562/4 resistant cells sensitized to cytostatic drugs and indirect expression of upregulation of heme oxygenase-1 (HO-1) and ferritin in U937 cells (human histiocytic lymphoma) after TF/Asc treatment. − …”

Section: Therapymentioning

confidence: 99%

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Metalloporphyrins in Medicine: From History to Recent Trends

Faustova

Nikolskaya

Sokół

et al. 2020

ACS Appl. Bio Mater.

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The history of metalloporphyrins dates back more than 200 years ago. Metalloporphyrins are excellent catalysts, capable of forming supramolecular systems, participate in oxygen photosynthesis, transport, and used as contrast agents or superoxide dismutase mimetics. Today, metalloporphyrins represent complexes of conjugated π-electron system and metals from the entire periodic system. However, the effect of these compounds on living systems has not been fully understood, and researchers are exploring the properties of metalloporphyrins thereby extending their further application. This review provides an overview of the variety of metalloporphyrins that are currently used in different medicine fields and how metalloporphyrins became the subject of scientists’ interest. Currently, metalloporphyrins utilization has expanded significantly, which gave us an opprotunuty to summarize recent progress in metalloporphyrins derivatives and prospects of their application in the treatment and diagnosis of different diseases.

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Section: Therapymentioning

confidence: 99%

Section: Therapymentioning

confidence: 99%

Metalloporphyrins in Medicine: From History to Recent Trends

Faustova

Nikolskaya

Sokół

et al. 2020

ACS Appl. Bio Mater.

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Ferritin self-assembly, structure, function, and biotechnological applications

Sudarev

Dolotova²,

Bukhalovich³

et al. 2023

International Journal of Biological Macromolecules

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The Value of Basal Expression Level of Hemoxygenase-1 for Sensitivity of Human Melanoma Cells to Oxidative Stress in Vitro

Sidorova

Соломко

Khochenkova

et al. 2020

Rossijskij bioterapevtičeskij žurnal

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Introduction. The molecular basis of radio- and photodynamic therapy (PDT), the mechanism of action of a number of antitumor chemotherapy drugs is oxidative stress (OS). The enzyme hemoxygenase-I (НO-1), a molecular marker of OS, is a key participant in the system of protection and adaptation of tumor cells under stress.Objective. To find out whether the sensitivity of human melanoma tumor cells to OS depends on the basal and modulator-induced levels of НO-1 expressionMaterial and methods. Human melanoma cell lines were used in the study. The expression of mRNA НO-1 in cells was studied by real-time RT-PCR, the reactive oxygen species content in cells – by flow cytometry and the cytotoxicity of drugs – by MTT assay.Results. According to our data, human melanoma cells have different basal levels of HO-1 transcription: high (3.0–3.5 o. u.) in lines MelIL, MelP, medium (1.5 o. u.) in lines MeWo, MelZ, MelIbr and low (0.5 o. e.) – MelMe, A375).There is no direct correlation between the level of basal cell expression of HO-1 and their sensitivity to the OS inducer – Н2О2. The hemin-induced increase in HO-1 expression in cells is accompanied by doubled resistance to Н2О2. It was found that HO-1 repression in the presence of apigenin was registered in melanoma cells with different basal levels, but sensitization to Н2О2 (2–4 times) was observed only for cells with medium (MeWo) and low (A375) levels of basal HO-1 expression. It was found that the decrease in basal expression of HO-1 induced by apigenin is accompanied by an increase in the reactive oxygen species content in cells.Conclusions. The results of our research allow us to recommend natural flavon apigenin, a modulator of HO-1 expression, for inclusion in the chemotherapy and PDT regimens to increase the effectiveness of human melanoma treatment.

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Heme Oxygenase-1/Ferritin in Protection of Leukemia Cells from Oxidative Stress Induced by Catalytic System “Teraphtal + Ascorbic Acid”

Cited by 3 publications

References 76 publications

Metalloporphyrins in Medicine: From History to Recent Trends

Metalloporphyrins in Medicine: From History to Recent Trends

Ferritin self-assembly, structure, function, and biotechnological applications

The Value of Basal Expression Level of Hemoxygenase-1 for Sensitivity of Human Melanoma Cells to Oxidative Stress in Vitro

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