Hematuria Associated With SARS-CoV-2 Infection in a Child

Almeida, Flávia Jacqueline; Olmos, Rodrigo Díaz; Oliveira, Danielle Bruna Leal; Monteiro, Cairo Oliveira; Thomazelli, Luciano Matsumiya; Durigon, Edison Luiz; Sáfadi, Marco Aurélio Palazzi

doi:10.1097/inf.0000000000002737

Cited by 27 publications

(38 citation statements)

References 5 publications

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“…Renal, cardiovascular and neurological manifestations were also observed. Renal manifestations were reported with hematuria, 20 , 35 proteinuria, 20 uremia, 20 and increased creatinine 18 as the main signs. Acute kidney injury was identified in 38 patients, 16 , 20 representing a frequent complication.…”

Section: Resultsmentioning

confidence: 99%

“… 12 However, due to the outrageous number of infected children, some fatal cases are being reported, associated with extrapulmonary complications, pointing to a need of medical and scientific attention. 13 , 14 , 15 , 16 , 17 , 18 , 19 , 20 , 21 , 22 , 23 , 24 , 25 , 26 , 27 , 28 , 29 , 30 , 31 , 32 , 33 , 34 , 35 , 36 , 37 , 38 , 39 , 40 …”

Section: Introductionmentioning

confidence: 99%

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Extrapulmonary manifestations of COVID-19 in children: a comprehensive review and pathophysiological considerations

Pousa¹,

Mendonça²,

Oliveira³

et al. 2021

Jornal de Pediatria

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Objective The aim of this review was to summarize the most common extrapulmonary manifestations in pediatric patients with COVID-19, as well as to discuss clinical, epidemiological, and pathophysiological aspects of these clinical presentations in children. Source of data An extensive search of literature was performed in order to identify pediatric cases with extrapulmonary manifestations between January 1, 2020 and June 21, 2020. Generic keywords, such as “Novel coronavirus” or “Novel coronavirus 2019” or “2019 nCoV” or “COVID-19” or “SARS-CoV-2” were searched on PubMed database, associated either with age filters or generic pediatric terms. Summary of findings A total of 28 articles, including 199 patients, were considered suitable to review and data extraction. The main findings were summarized in tables. The main non-pulmonary manifestations in pediatric patients, in decreasing order of frequency, were gastrointestinal, renal, cardiovascular, neurological, hematological and lymphatic, cutaneous, hepatic, ocular, olfactory, and gustatory. Multisystem impairment and Kawasaki-like disease were also described. Conclusions Differences in immune response of children and variations of tissue expression of angiotensin converting enzyme 2, the virus receptor, are likely to influence clinical, epidemiological, and pathophysiological patterns of the disease.

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Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Extrapulmonary manifestations of COVID-19 in children: a comprehensive review and pathophysiological considerations

Pousa¹,

Mendonça²,

Oliveira³

et al. 2021

Jornal de Pediatria

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show abstract

“…Kidney injury has been described in viral respiratory infections including adenovirus, influenza A and B, and other pathogens. Kidney injury in patients severely affected with COVID-19 appears to be a frequent finding, with a wide range of manifestations, from microhematuria, isolated proteinuria, elevation of azotemia products in serum, and severe acute kidney injury [3,7]. However, based on the data review by the researchers, a complete nephrotic picture has not been reported.…”

Section: Discussionmentioning

confidence: 99%

“…Isolated nephrological manifestations in COVID-19 have also been reported: hematuria in a pediatric case [ 7 ] and hematuria and albuminuria in critical patients, suggesting an association of COVID-19 with nephritis glomerular changes [ 8 ]. Nephritis-like histology was also described in postmortem samples from patients with COVID-19 [ 9 ].…”

Section: Introductionmentioning

confidence: 99%

COVID-19 associated with onset nephrotic syndrome in a pediatric patient: coincidence or related conditions?

et al. 2020

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Background COVID-19 is less frequent in children than in adults and affects the former less severely; despite the fact that respiratory symptoms are the most frequent, in some cases unusual manifestations can be seen. Case-diagnosis We present a 15-year-old boy who tested positive for SARS-COV-2 infection and onset of nephrotic syndrome, without antecedent of kidney disease and who had normal urine tests shortly before being affected by COVID-19. Conclusions The patient described in this report, who was admitted due to nephrotic syndrome and respiratory syndrome, tested positive for COVID-19. He, based on the data review by the researchers, is the first reported case of COVID-19 with simultaneous onset of complete picture of nephrotic syndrome. The presence of both diagnoses could be a coincidence or an unusual form of presentation of COVID-19.

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“…The most common signs and symptoms in children and adolescents are fever and cough, followed by headache, sore throat, myalgia, shortness of breath, nausea, abdominal pain, vomiting, and diarrhea ( 3 , 6 , 10 ). Other clinical features, such as renal, cutaneous, olfactory, gustatory, neurological, and ocular features, are infrequently reported in pediatric COVID-19 populations ( 3 , 8 , 10 ). Leucopenia, lymphopenia, and increased inflammatory markers are the most frequently reported laboratory abnormalities in these patients ( 2 , 3 ).…”

Section: Introductionmentioning

confidence: 99%

Severe clinical spectrum with high mortality in pediatric patients with COVID-19 and multisystem inflammatory syndrome

Pereira

Litvinov

Farhat

et al. 2020

Clinics

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Hematuria Associated With SARS-CoV-2 Infection in a Child

Cited by 27 publications

References 5 publications

Extrapulmonary manifestations of COVID-19 in children: a comprehensive review and pathophysiological considerations

Extrapulmonary manifestations of COVID-19 in children: a comprehensive review and pathophysiological considerations

COVID-19 associated with onset nephrotic syndrome in a pediatric patient: coincidence or related conditions?

Severe clinical spectrum with high mortality in pediatric patients with COVID-19 and multisystem inflammatory syndrome

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