COVID-19 associated with onset nephrotic syndrome in a pediatric patient: coincidence or related conditions?

Alvarado, Amado; Franceschi, Gabriela; Resplandor, Evelin; Sumba, Jeannethe; Orta, Nelson

doi:10.1007/s00467-020-04724-y

Cited by 33 publications

(34 citation statements)

References 11 publications

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“…Various forms of kidney involvement have been reported in children in the context of COVID-19 infection. AKI is the most prevalent but there are also two recent reports of association of COVID-19 infection and nephrotic syndrome in children [ 10 , 11 ].…”

Section: Discussionmentioning

confidence: 99%

“…The common kidney pathologies following COVID-19 infection include ATI [7,8], direct renal cell invasion by the virus, immune dysregulation (initiated by systemic cytokine activation) [2,8], and thrombotic microangiopathy [3][4][5][6][7][8][9][10][11]. Various patterns of glomerular injury have been described associated with COVID-19 infection in adult studies.…”

Section: Discussionmentioning

confidence: 99%

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Acute necrotizing glomerulonephritis associated with COVID-19 infection: report of two pediatric cases

et al. 2021

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Background Coronavirus disease 2019 (COVID-19) is thought to cause kidney injury via a variety of mechanisms. The most common reported kidney injury following COVID-19 infection is acute tubular injury (ATI); however, the procoagulant state induced by the virus may also damage the kidneys. Case-diagnosis/treatment Herein, we report two cases of acute necrotizing glomerulonephritis (GN) with fibrinoid necrosis in the context of COVID-19 infection. The one with more chronic features in the kidney biopsy progressed to permanent kidney failure but the second one had an excellent response to glucocorticoid pulse therapy with subsequent normal kidney function at 2month follow-up. Conclusions Both reported cases had an acute presentation of kidney injury with positive nasopharyngeal PCR test for COVID-19. Based on the data review by the researchers, this is the first report of acute necrotizing GN associated with COVID-19 infection.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Acute necrotizing glomerulonephritis associated with COVID-19 infection: report of two pediatric cases

et al. 2021

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“…There is less information available on clinical outcomes in children, as compared to adults. Till date, there are few reported cases of kidney involvement, including NS, in children with COVID-19 [ 1 , 5 ]. A retrospective case–control study was conducted among children with COVID-19 in Wuhan [ 9 ].…”

Section: Discussionmentioning

confidence: 99%

“…There is limited information about COVID-19 in children with nephrotic syndrome (NS). Only one case that describes simultaneous onset of NS and COVID-19 has been reported [ 5 ]. A report from Spain described 16 patients with chronic kidney disease with mild respiratory symptoms and few radiological manifestations.…”

Section: Introductionmentioning

confidence: 99%

Nephrotic syndrome relapse in a boy with COVID-19

et al. 2021

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Clinical data on coronavirus disease-19 (COVID-19) in children during the management of nephrotic syndrome (NS) is lacking. Patients on prednisolone are compromised hosts at the risk of severe infections. Some infections may induce NS relapse. We describe the clinical course of a child with NS and COVID-19. A 3-year-old boy was admitted with clinical and laboratory findings indicative of NS. Induction therapy with prednisolone (2 mg/kg/day) induced complete remission. While tapering the dose, he was infected with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). He developed a high fever and periorbital edema. Urinalysis revealed proteinuria (protein-creatinine ratio: 6.3 g/gCr). He was transferred to our hospital for the concurrent management of COVID-19 and NS relapse. As proteinuria worsened, the prednisolone dose was increased to 2 mg/kg/day. Proteinuria gradually improved, and remission was noted a week after initiating full-dose steroid treatment. The fever subsided after 2 days without treatment for COVID-19. Anti-SARS-CoV-2 antibody including IgG levels decreased in the early convalescent phase. To the best of our knowledge, this is the first reported case with the recurrence of NS triggered by the SARS-CoV-2 infection in Asia. SARS-CoV-2 infection may induce NS relapse. Daily administration of full-dose of prednisolone may be effective for managing the recurrence of NS associated with SARS-CoV-2 infection.

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“…Therefore, clinical data on COVID-19 in children during the management of nephrotic syndrome (NS) is also lacking. To date, only one case who developed COVID-19 with simultaneous onset of NS has been reported [1]. A report from Spain described 16 patients with chronic kidney diseases presenting mild respiratory symptoms and a few radiological manifestations.…”

Section: Dear Editorsmentioning

confidence: 99%

SARS-CoV-2 infection associated with the recurrence of nephrotic syndrome in a Japanese boy

Enya

Sugimoto

2020

Pediatr Nephrol

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COVID-19 associated with onset nephrotic syndrome in a pediatric patient: coincidence or related conditions?

Cited by 33 publications

References 11 publications

Acute necrotizing glomerulonephritis associated with COVID-19 infection: report of two pediatric cases

Acute necrotizing glomerulonephritis associated with COVID-19 infection: report of two pediatric cases

Nephrotic syndrome relapse in a boy with COVID-19

SARS-CoV-2 infection associated with the recurrence of nephrotic syndrome in a Japanese boy

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