SARS-CoV-2 infection associated with the recurrence of nephrotic syndrome in a Japanese boy

Enya, Takuji; Sugimoto, Kunihisa

doi:10.1007/s00467-020-04782-2

Cited by 6 publications

(3 citation statements)

References 2 publications

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“…Infection is a recognized risk factor for both nephrotic relapses and VTE [ 8 , 10 , 13 ]. Nephrotic relapses following COVID-19 infection have been reported with and without thrombotic complications [ 14 – 19 ]. Our patient developed abdominal symptoms after the diagnosis of COVID-19 infection as may occur in up to a half of those infected with this virus [ 20 ].…”

Section: Discussionmentioning

confidence: 99%

Splanchnic venous thrombosis in a nephrotic patient following COVID-19 infection: a case report

et al. 2021

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Background As the COVID-19 pandemic spread worldwide, case reports and small series identified its association with an increasing number of medical conditions including a propensity for thrombotic complications. And since the nephrotic syndrome is also a thrombophilic state, its co-occurrence with the SARS-CoV-2 infection is likely to be associated with an even higher risk of thrombosis, particularly in the presence of known or unknown additional risk factors. Lower extremity deep vein thrombosis (DVT) and pulmonary embolism (PE) are the most common manifestations of COVID-19-associated hypercoagulable state with other venous or arterial sites being much less frequently involved. Although splanchnic vein thrombosis (SVT) has been reported to be 25 times less common than usual site venous thromboembolism (VTE) and rarely occurs in nephrotic patients, it can have catastrophic consequences. A small number of SVT cases have been reported in COVID-19 infected patients in spite of their number exceeding 180 million worldwide. Case presentation An unvaccinated young adult male with steroid-dependent nephrotic syndrome (SDNS) who was in a complete nephrotic remission relapsed following contracting SARS-CoV-2 infection and developed abdominal pain and diarrhea. Abdominal US revealed portal vein thrombosis. The patient was anticoagulated, yet the SVT rapidly propagated to involve the spleno-mesenteric, intrahepatic and the right hepatic veins. In spite of mechanical thrombectomy, thrombolytics and anticoagulation, he developed mesenteric ischemia which progressed to gangrene leading to bowel resection and a complicated hospital course. Conclusion Our case highlights the potential for a catastrophic outcome when COVID-19 infection occurs in those with a concomitant hypercoagulable state and reminds us of the need for a careful assessment of abdominal symptoms in SARS-CoV-2 infected patients.

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Section: Discussionmentioning

confidence: 99%

Splanchnic venous thrombosis in a nephrotic patient following COVID-19 infection: a case report

et al. 2021

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“…Investigations into the clinical impact of SARS‐CoV‐2 infection in children, especially on nephrotic syndrome (NS), are ongoing. Three cases were published almost simultaneously in 2020 1–3 while Melgosa et al 4 . reported 16 patients with chronic renal disease in Spain.…”

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confidence: 99%

“…Investigations into the clinical impact of SARS-CoV-2 infection in children, especially on nephrotic syndrome (NS), are ongoing. Three cases were published almost simultaneously in 2020 [1][2][3] while Melgosa et al 4 reported 16 patients with chronic renal disease in Spain. Among these patients, two with steroid-dependent NS (SDNS) relapsed; however, response to prednisone treatment was good in both cases, without complications.…”

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confidence: 99%