Hematoporphyrin Derivative: A Possible Aid in the Diagnosis and Therapy of Carcinoma of the Bladder

Abstract

The distribution of hematoporphyrin derivative has been studied in patients undergoing transurethral resections and total cystectomy for carcinoma of the bladder. Although hematoporphyrin derivative fluorescence was not confined to malignant tissues with the dose used there was preferential localization in malignant and pre-malignant epithelium. Also high intensity illumination of an area of hematoporphyrin derivative sensitized carcinoma caused tumor destruction. Therefore, it is suggested that hematoporphyrin derivative could be used as an aid to the diagnosis and treatment of carcinoma of the bladder.

Cell uptake, distribution and response to aluminium chloro sulphonated phthalocyanine, a potential anti-tumour photosensitizer

“…The tumoricidal effect of HpD following light exposure is generally attributed to the formation of singlet oxygen generated by the transfer of energy from the excited HpD to tissue oxygen (Weishaupt et al, 1976;Moan et al, 1979). While the reasons for the preferential accumulation of HpD in neoplastic tissue, and even the exact basis of its anti-tumour effects, remain to be elucidated it has been used in the treatment of human cancer (Kelly & Snell, 1976;Dougherty et al, 1979;Forbes et al, 1980;Hayata et al, 1980;Dahlman et al, 1983;Ha et al, 1983;Carruth et al, 1985). However, HpD has many characteristics which make it less than an ideal photosensitizer.…”

Photodynamic effects of haematoporphyrin derivative on synchronized and asynchronous cells of different origin

“…THE INTRODUCTION of haematoporphyrin derivative (HPD) as a selective tumour-seeking and photodynamically active agent has led to the development of a new treatment modality for cancer (Dougherty et al, 1976aKelly & Snell, 1976;Forbes et al, 1980). A selective effect of the treatment on malignant tissue has been demonstrated (Kelly et al, 1975).…”

Multiplication of human NHIK 3025 cells exposed to porphyrins in combination with light

“…TIIE PHOTOI)YNAMIC EFFECT of porphyrins has been taken advantage of in recent successful clinical trials with photochemotherapy of cancer in the presence of haematoporphyrin derivative (HPD) (Kelly & Snell, 1976;Dougherty et al, 1978). In these and other studies a surprisingly rapid necrosis of solid tumours has been found.…”