Hematopoietic Stem Cell Transplantation for Systemic Sclerosis: If You Are Confused, Remember: “It Is a Matter of the Heart”

Burt, Richard K.; Shah, Sanjiv J.; Gheorghiade, Mihai; Ruderman, Eric; Schroeder, James

doi:10.3899/jrheum.111302

Cited by 21 publications

(13 citation statements)

References 23 publications

(27 reference statements)

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“…The RI was higher in the presence of gastrointestinal involvement at SSc diagnosis (HR: 2.31; 95% CI 1.14-4.67; P = 0.02). These results are supported by previous studies where we 13,14 and others 15 had shown that heart involvement in SSc negatively affects patient outcome.…”

Section: Resultssupporting

confidence: 82%

Does ex vi vo CD34+ positive selection influence outcome after autologous hematopoietic stem cell transplantation in systemic sclerosis patients?

Soga

Labopin

Henes

et al. 2015

Bone Marrow Transplant

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This EBMT Autoimmune Disease Working Party study aimed to evaluate the influence of CD34+ positive graft selection (CD34+) on the outcome of systemic sclerosis (SSc) patients after autologous hematopoietic stem cell transplantation (AHSCT). Clinical and laboratory data from 138 SSc patients at diagnosis, before and after AHSCT were retrospectively analyzed. CD34+ selection was performed in 47.1% (n = 65) patients. By multivariate analysis adjusting for all factors differing between the two groups (without or with CD34+), there was no statistically significant difference in terms of overall survival (hazard ratio (HR): 0.98, 95% confidence interval (CI) 0.40-2.39, P = 0.96), PFS (HR: 1.55, 95% CI 0.83-2.88, P = 0.17) and incidence of relapse or progression (HR: 1.70, 95% CI 0.85-3.38, P = 0.13). We demonstrate that CD34+ does not add benefit to the outcome of SSc patient treated with AHSCT. These findings should be further confirmed by prospective randomized trials.

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Section: Resultssupporting

confidence: 82%

Does ex vi vo CD34+ positive selection influence outcome after autologous hematopoietic stem cell transplantation in systemic sclerosis patients?

Soga

Labopin

Henes

et al. 2015

Bone Marrow Transplant

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“…One of the key factors deciding the success of the transplant has been cardiac function. The presence of pulmonary artery hypertension (pulmonary artery systolic pressure more than 40mmHg) 44 , pericardial effusion of more than 1cm on a computed tomography of the chest 45 , evidence of constrictive pericarditis, and tricuspid peak systolic excursion of less than 1.8cm should be considered exclusion criteria for transplantation 46,47 . With careful patient selection, transplant mortality has been reduced from 9% to 6% 48 .…”

Section: Discussionmentioning

confidence: 99%

Haematopoietic Stem Cell Transplantation in Systemic Lupus Erythematosus: A Case Report and Review of the Literature

Fong

Loh

Yoong

2013

Proceedings of Singapore Healthcare

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Systemic lupus erythematosus (SLE) is a chronic inflammatory disease with a relapsing and remitting course, which is often treatable with immunosuppressive therapy. However, we describe a patient with severe and refractory thrombotic thrombocytopaenic purpura (TTP) secondary to SLE that did not respond to high dose corticosteroids, cyclophosphamide (CyC), vincristine, rituximab, and plasmapheresis. She eventually required haematopoietic stem cell transplantation (HSCT) to bring the disease under control. She is in disease remission three years post-stem cell transplantation. HSCT is a possible treatment option for severe and refractory SLE when conventional therapy has failed. HSCT for other rheumatologic diseases is also reviewed.

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“…In case of abnormalities found in the previous steps, stress ventriculography and even cardiac catheterization should follow, the latter if ischemic areas are detected. Burt et al also suggest detailed cardiac evaluations, including invasive and costly tests, such as right heart catheterization and magnetic resonance imaging (MRI) (36) .…”

Section: Autologous Hematopoietic Stem Cell Transplantation: Internatmentioning

confidence: 99%

Guidelines of the Brazilian Society of Bone Marrow Transplantation on hematopoietic stem cell transplantation as a treatment for the autoimmune diseases systemic sclerosis and multiple sclerosis

Oliveira¹,

Hamerschlak²,

Moraes³

et al. 2013

Revista Brasileira De Hematologia E Hemoterapia

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Hematopoietic Stem Cell Transplantation for Systemic Sclerosis: If You Are Confused, Remember: “It Is a Matter of the Heart”

Cited by 21 publications

References 23 publications

Does ex vi vo CD34+ positive selection influence outcome after autologous hematopoietic stem cell transplantation in systemic sclerosis patients?

Does ex vi vo CD34+ positive selection influence outcome after autologous hematopoietic stem cell transplantation in systemic sclerosis patients?

Haematopoietic Stem Cell Transplantation in Systemic Lupus Erythematosus: A Case Report and Review of the Literature

Guidelines of the Brazilian Society of Bone Marrow Transplantation on hematopoietic stem cell transplantation as a treatment for the autoimmune diseases systemic sclerosis and multiple sclerosis

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