Hematopoiesis in young human embryos

Bloom, William; Bartelmez, G. W.

doi:10.1002/aja.1000670103

Cited by 134 publications

(50 citation statements)

References 7 publications

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“…We further noted a morphologic similarity (Figure 3) between fully differentiated MHE clusters and classic histologic descriptions of human yolk sac by Bloom and Bartelmez (1940). These authors described hematocytoblasts, in precirculatory day 13 to 24 human yolk sac sections, as the primary hematopoietic progenitors for developing yolk sac blood islands, and arose "by direct transformation of mesenchymal cells."…”

Section: Human Embryonic Stem Cells Model the Hemangioblastic Originssupporting

confidence: 64%

Blood-Forming Endothelium in Human Ontogeny: Lessons From In Utero Development and Embryonic Stem Cell Culture

Zambidis

Oberlin

Tavian

et al. 2006

Trends in Cardiovascular Medicine

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During the early weeks of human gestation, hematopoietic cells first emerge within the extraembryonic yolk sac (primitive hematopoiesis) and secondarily within the truncal arteries of the embryo. This second wave includes the stem cells giving rise to adult-type lymphohematopoiesis. In both yolk sac blood islands and embryonic aorta, hematopoietic cells arise in the immediate vicinity of vascular endothelial cells. In vitro hematopoietic differentiation of endothelial cells stringently sorted from human embryonic and fetal blood-forming tissues has demonstrated that primitive endothelium lies at the origin of incipient hematopoiesis. These anatomically and temporally localized blood-forming endothelial cells are ultimately derived from a rare subset of mesodermal angio-hematopoietic stem cells, or hemangioblasts. The evidence for an early progenitor of blood-forming cells within the walls of human embryonic blood vessels concurs with parallel data obtained from lower vertebrate, avian, and murine models. Importantly, converging results have recently been obtained with in vitro differentiated human embryonic stem cells, in which we have modeled primitive and definitive hematopoiesis via an endothelium-like developmental intermediate.

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Section: Human Embryonic Stem Cells Model the Hemangioblastic Originssupporting

confidence: 64%

Blood-Forming Endothelium in Human Ontogeny: Lessons From In Utero Development and Embryonic Stem Cell Culture

Zambidis

Oberlin

Tavian

et al. 2006

Trends in Cardiovascular Medicine

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“…This is too early a stage to be accessed from elective pregnancy interruptions. Yet, occasional histological investigations have indicated that the human yolk sac produces mostly erythroid cells (Bloom and Bartelmez, 1940). The occasional presence of macrophages and primitive megakaryocytes has been also described (Fukuda, 1973).…”

Section: The Yolk Sacmentioning

confidence: 99%

Embryonic development of the human hematopoietic system

Tavian

Péault²

2005

Int. J. Dev. Biol.

227

166

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Human hematopoiesis is initiated in the yolk sac during the third week of development. At the same time the capacity to produce blood cells also arises in the embryo, within the splanchnopleura, but this potential is not expressed before day 27, when clustered hematopoietic stem cells emerge from the ventral wall of the aorta and vitelline artery. Budding of hematopoietic cells from vessel walls reflects the re-differentiation of local endothelial cells, which are likely derived from angio-hematopoietic mesodermal ancestors emigrated from the splanchnopleura. Yolk sac-derived stem cells are limited to myelo-erythroid development, whereas those born in the embryo are, in addition, lymphopoietic and therefore represent the first multi-potent, adulttype blood progenitors that appear in human ontogeny, preceding shortly the onset of liver hematopoiesis. These results allowed the establishment of a novel hierarchy of blood-forming tissues in human development and induced an in depth reconsideration of the very origin of definitive human hematopoiesis. These results also fully corroborate the outcome of experiments performed in parallel in avian and mouse embryos and point to the conservation in all higher vertebrates of an ancestral route of blood cell production via embryonic vessel walls.

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“…Tight groups of 'mesenchymal' cells, of mesoderm origin, that are adjacent to the endoderm, differentiate into haematopoietic cells surrounded by endothelial cells, which later remodel to form the yolk sac vascular plexus. Large primitive nucleated erythrocytes represent the major haematopoietic output from the yolk sac at CS 7-8 (16-18.5 dpc), with the occasional presence of primitive macrophages and megakaryocytes (Bloom and Bartelmez, 1940;Fukuda, 1973;Luckett, 1978). By CS 10 (21-22 dpc), the first primitive erythroblasts can be observed inside the cardiac cavity, marking the onset of blood circulation, followed by appearance of the first CD45 + (PTPRC + ) cells, (Tavian et al, 1999), similar to analyses in the mouse (Ghiaur et al, 2008).…”

Section: The Yolk Sacmentioning

confidence: 99%

Human haematopoietic stem cell development: from the embryo to the dish

et al. 2017

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Haematopoietic stem cells (HSCs) emerge during embryogenesis and give rise to the adult haematopoietic system. Understanding how early haematopoietic development occurs is of fundamental importance for basic biology and medical sciences, but our knowledge is still limited compared with what we know of adult HSCs and their microenvironment. This is particularly true for human haematopoiesis, and is reflected in our current inability to recapitulate the development of HSCs from pluripotent stem cells in vitro. In this Review, we discuss what is known of human haematopoietic development: the anatomical sites at which it occurs, the different temporal waves of haematopoiesis, the emergence of the first HSCs and the signalling landscape of the haematopoietic niche. We also discuss the extent to which in vitro differentiation of human pluripotent stem cells recapitulates bona fide human developmental haematopoiesis, and outline some future directions in the field.

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Hematopoiesis in young human embryos

Cited by 134 publications

References 7 publications

Blood-Forming Endothelium in Human Ontogeny: Lessons From In Utero Development and Embryonic Stem Cell Culture

Blood-Forming Endothelium in Human Ontogeny: Lessons From In Utero Development and Embryonic Stem Cell Culture

Embryonic development of the human hematopoietic system

Human haematopoietic stem cell development: from the embryo to the dish

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