Hematological study on a case with cerebellar hemangioblastoma associated with erythrocytosis, with special reference to a erythropoiesis-stimulating activity present in the fluid of the cyst of tumor

Kawafuchi, Jun‐ichi; Shirakura, Takuo; Azuma, Masami; Tsunoda, Tadao; Maekawa, Tadashi

doi:10.1007/bf01632856

Cited by 15 publications

(3 citation statements)

References 5 publications

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“…Haemangioblastomas are complicated by polycytaemia in 9-49% of the cases in the literature. Poly- cytaemia is attributed by some authors to an erythropoetic factor emanating from the tumour or the renal lesions6- 8,17,23,26,47,55,62,63. Assuming a red cell count of 4.5 million as the upper limit of normal, polycytaemia occurred in 36% of our cases.…”

Section: Discussionmentioning

confidence: 91%

Posterior fossa haemangioblastomas

Julow

Bálint²,

Gortvai

et al. 1994

Acta neurochir

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36 consecutive years' experience in treating 104 cases of posterior fossa haemangioblastomas is described and discussed. The mortality was 24%, with a tendency to decrease, reaching 20% in the last 15 years. About half the patients returned to neurological normality and full working capacity. Dividing the lesions into solid and cystic tumours, cystic tumours were more frequent, their survival was longer, recurrence less and postoperative state somewhat better.

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Section: Discussionmentioning

confidence: 91%

Posterior fossa haemangioblastomas

Julow

Bálint²,

Gortvai

et al. 1994

Acta neurochir

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“…Previous studies on the biochemistry of hemangioblastoma cyst fluid are inconsistent. Some investigations found that cyst fluid contains proteins from hemangioblastoma tumor cells, [19][20][21][22] whereas others observe that cyst fluid is similar to serum. 6,23,24 However most authors do not clearly differentiate between intra-and peritumoral cyst fluid.…”

Section: Discussionmentioning

confidence: 99%

“…6,23,24 However most authors do not clearly differentiate between intra-and peritumoral cyst fluid. [19][20][21][22][23][24] To date no analysis of intratumoral hemangioblastoma cyst fluid has been reported. We performed a detailed characterization of the biochemical composition of intratumoral hemangioblastoma cyst fluid by 2D gel electrophoresis and sequencing of consistently expressed proteins and compared the intratumoral cyst fluid with serum and hemangioblastoma tumor tissue and peritumoral cyst fluid by 2D proteomic profiling.…”

Section: Discussionmentioning

confidence: 99%

Proteomic analysis of hemangioblastoma cyst fluid

Gläsker¹,

Vortmeyer²,

Lonser³

et al. 2006

Cancer Biology & Therapy

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Ultrastructure of cerebellar hemangioblastoma

Chaudhry

Montes

Cohn

1978

Cancer

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Light and ultrastructural features of a cerebellar hemangioblastoma in a 56-year-old man are described in detail. The neoplasm was composed of three major cell types: endothelial cells, pericytes, and stromal cells. The endothelial cells lined the fenestrated vascular channels. The pericytes were ensheathed by their own basal lamina which separated them from the basal lamina covering the endothelium. The stromal cells contained, in addition to the conventional organelles, numerous membrane-bound lipid inclusions, annulate lamellae, and nuclear bodies. There were also present transitional cells which shared the fine structure of all the three major cell types. Histogenetically, the tumor was considered to be of vascular origin. The stromal cells represented the stem cells which, under the neoplastic influence, continued to proliferate and differentiate into "vasoformative" elements (pericytes and endothelium) which formed new blood vessels. The transitional forms between the stromal cells and the "vasoformative" elements suggested that the cellular components of a hemangioblastoma shared a common ancestry, most likely of an angioblastic lineage.

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Hematological study on a case with cerebellar hemangioblastoma associated with erythrocytosis, with special reference to a erythropoiesis-stimulating activity present in the fluid of the cyst of tumor

Cited by 15 publications

References 5 publications

Posterior fossa haemangioblastomas

Posterior fossa haemangioblastomas

Proteomic analysis of hemangioblastoma cyst fluid

Ultrastructure of cerebellar hemangioblastoma

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