Ultrastructure of cerebellar hemangioblastoma

Chaudhry, Anand P.; Montes, Mario; Cohn, George A.

doi:10.1002/1097-0142(197810)42:4<1834::aid-cncr2820420423>3.0.co;2-z

Cited by 71 publications

(22 citation statements)

References 40 publications

(4 reference statements)

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“…Among the stromal cells, Chaudry et al identified cells with transitional features among stromal cells, endothelial cells, and pericytes. They also found ultrastructural features characteristic for embryonic cells and concluded that stromal cells and vasoformative elements share ga common ancestry, most likely angioblastic lineage (38). Therefore, although a synopsis of previous ultrastructural studies is similarly as inconclusive as previous immunohistochemical studies, ultrastructural studies recognized embryonic characteristics in the stromal cells and variable phenotypes of differentiation.…”

Section: Discussionmentioning

confidence: 97%

Hemangioblastomas Share Protein Expression with Embryonal Hemangioblast Progenitor Cell

Gläsker

Xia

et al. 2006

Cancer Research

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Hemangioblastomas are central nervous system (CNS) tumors of unknown histogenesis, which can occur sporadically or in von Hippel-Lindau disease. Hemangioblastomas are composed of neoplastic ''stromal'' cells of unknown origin, accompanied by intensive reactive angiogenesis. Failure to specify the cytologic origin of the stromal cell has precluded the development of nonsurgical therapies and limits understanding of its basic biology. We report that the stromal cells express proteins (Scl, brachyury, Csf-1R, Gata-1, Flk-1, and Tie-2) that characterize embryonic progenitor cells with hemangioblastic differentiation potential and conclude that embryonic progenitors with hemangioblast potential represent a possible cytologic equivalent of the stromal cell. We also identified a new autocrine/ paracrine stimulatory loop between the receptor Tie-2 and the hypoxia-inducible factor target Ang-1, which, combined with previous observations, suggests that a variety of autocrine loops may be initiated in hemangioblastomas, depending on the differentiation status of the tumor cells and the extent of HIF downstream activation. Finally, the consistent identification of Scl in the stromal cells may help explain the unique and characteristic topographical distribution of hemangioblastomas within the CNS. (Cancer Res 2006; 66(8): 4167-72)

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Section: Discussionmentioning

confidence: 97%

Hemangioblastomas Share Protein Expression with Embryonal Hemangioblast Progenitor Cell

Gläsker

Xia

et al. 2006

Cancer Research

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“…This high Lip peak in the tumor is compatible with the histological fi ndings: stromal cells in this tumor contain Lip. 6 Concerning the high Lip peak seen with proton MRS, it is also observed in other tumors, especially high-grade tumors such as high-grade gliomas, metastatic brain tumors, and anaplastic meningiomas. 7,8 Several authors have noted the necrotic component as the origin of the Lip peak in these tumors 9 but not in hemangioblastoma.…”

Section: Discussionmentioning

confidence: 99%

Proton magnetic resonance spectroscopy findings of hemangioblastoma

et al. 2010

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We report a case of proton magnetic resonance spectroscopy (MRS) of hemangioblastoma in a 56-yearold man with a history of hyperlipidemia who was suffering from an equilibrium disorder. Proton MRS revealed a high mobile lipids (Lip) peak between 0.9 and 1.4 ppm, which was compatible with histologically proven lipids in the tumor. No lactate peak was recognized. The creatine/phosphocreatine peak was low. Choline-containing compounds were increased. The N-acetylaspartate peak was absent, which indicated that the tumor is of nonneurogenic origin. Combined with the absence of the necrotic component on magnetic resonance imaging, this Lip peak on proton MRS could be the characteristic pattern of hemangioblastoma. These unique results of proton MRS can play an important role in the differential diagnosis of intracranial hemangioblastoma. However, further investigations are required to establish the typical characteristics of proton MRS of hemangioblastoma.

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“…CD10, EMA ) was useful for differential diagnosis of hemangioblastoma from metastatic renal cell carcinoma. Several electron microscopic studies have demonstrated the vascular origin of these cells 14,20 which is supported by the presence of WeibelPalade bodies 21 .…”

Section: Casesmentioning

confidence: 93%

Serebellar Hemangioblastoma: Dört Olgu Sunumu ve Literatür Incelemesi

Bakarış¹,

Yüksel²

2015

Cukurova Medical Journal

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Hemangioblastoma (HB) is a benign, slow-growing, highly vascular tumour of not well defined histological origin. These tumors make up about 1 to 2 percent of all intracranial neoplasms and occur primarily in the posterior fossa. Hemangioblastomas can occur sporadically but in about 20% to 30% cases, it is associated with von Hippel-Lindau (VHL) disease. Four cases of cerebellar haemangioblastoma, not associated with von Hippel-Lindau disease (sporadic haemangioblastomas), were presented and reviewed the relevant literature.Four hemangioblastomas of the central nervous system were examined with haematoxylin & eosin (H&E), reticulin stain and with a panel of antibodies including CD34, vimentin, NSE, S-100, CD99, CD56, GFAP, cytoceratin, epithelial membrane antigen (EMA), CD10. Of the 4 patients in this study 1 was male and 3 were female. Their ages ranged from 46 years to 60 years with a mean age of 54.75 years. All of them were as cystic nodules about 2-3 cm in diameter. In the histopathological examination, the tumors sections showed large and vacuolated stromal cells and numerous arborizing capillary-size blood vessels. Some tumors showed atypical nuclei. Vimentin was strongly positive both stromal cells and blood veessels in all tumors. In 4 cases of HB, some stromal cells were positive for NSE and CD99. Three tumors were positive for S-100 and CD56, two tumors were focally positive for glial fibrillary acidic protein (GFAP). CD34 immunostaining highlighted the arborizing and complex vascular network, whereas the tumor stromal cells were negative. The stromal cells were negative for epithelial markers such as cytokeratin, EMA and CD10. Ki-67 index was less than 1% of the tumor cells. Hemangioblastoma, a rare, benign tumors of uncertain histogenesis, is characterized histologically by the presence of vacuolated, lipid containing cells and a well developed, fine capillary network. The main histological differential diagnosis of HB is metastatic clear cell carcinoma. Additionally, because of the cystic mural features, pilocytic astrocytomas of the cerebellum must be separated from haemangioblastomas. Key words: hemangioblastoma, von Hippel-Lindau, cantral nervous system, histopathology ÖZET Hemanjiyoblastoma; histolojik kökeni henüz tam olarak tanımlanmamış, iyi huylu, yavaş büyüyen ve oldukça damarsal bir tümördür. Bu tümörler tüm kafatası içi neoplazmaların %1-2'sini oluşturur ki genellikle posterior fossada meydana gelirler. Hemanjiyoblastomalar normalde belirli aralıklarla düzensiz şekillerde meydana gelmektedirler ancak bu oran von hippel-lindau (VHL)'li vakaların yaklaşık %20-30'unda gözlenmektedirler. Burada Von Hippel-Lindau ile ilişkili olmayan dört serebellar hemanjiyoblastoma vakasının sunumu ve ilgili literatürün derlemesi yapıldı. Merkezi sinir sisteminde yer alan 4 hemanjiyoblastoma vakası hematoksilin-eosin, retikülin boya ve CD34, vimentin, NSE, S-100, CD99, CD56, GFAP, sitokeratin, epitelyal membran antijeni (EMA) ve CD10 antibiyotiklerini içeren bir panel ile incelemeleri yapıldı. Üç kad...

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Ultrastructure of cerebellar hemangioblastoma

Cited by 71 publications

References 40 publications

Hemangioblastomas Share Protein Expression with Embryonal Hemangioblast Progenitor Cell

Hemangioblastomas Share Protein Expression with Embryonal Hemangioblast Progenitor Cell

Proton magnetic resonance spectroscopy findings of hemangioblastoma

Serebellar Hemangioblastoma: Dört Olgu Sunumu ve Literatür Incelemesi

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