Hematological, physiological and genotoxicological effects of Match 5% EC insecticide on Biomphalaria alexandrina snails

Ibrahim, Amina M.; Ahmed, Amira Kamal; Bakry, Fayez A.; Abdel-Ghaffar, Fathy

doi:10.1016/j.ecoenv.2017.09.059

Cited by 38 publications

(23 citation statements)

References 34 publications

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“…C. insecticide. These results were in accordance with that of Ibrahim et al (2018) who recorded a significant decrease in total number of hemocytes after exposing B. alexandrina snails to the insecticide lufenuron 5% EC. Also, these findings were supported by the study of (Mossalem et al, 2013) who stated that the number of hemocytes of B. alexandrina snails decreased after exposure to an antimalarial agent called Artemether.…”

Section: Discussionsupporting

confidence: 93%

“…Freshwater snails can act as bioindicators of environmental pollution (Ibrahim et al, 2018). The present results showed that the lethal concentrations (LC90 and LC50) of Bestacid E.C insecticide on B. alexandrina snails after exposure for 24 h were 31.7 and 25 mg/l, respectively.…”

Section: Discussionmentioning

confidence: 51%

“…They were considered as potent pollutants of the water environment with undesirable effects on non-target organisms such as fish and water animals (Guner, 2016). Invertebrates played as bioindicators to monitor environmental pollution in the ecosystem (Ibrahim et al, 2018). Among invertebrate animals, freshwater snails are commonly used in acute and chronic toxicity studies of chemicals (Wilson-Sanders, 2011).…”

Section: Introductionmentioning

confidence: 99%

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The ameliorative potential of the ethanol extract of the plant Ocimum basilicum on Biomphalaria alexandrina snails exposed to the insecticide Bestacid

Mossalem¹,

Ibrahim²

2019

Egypt. J. of Aquatic Biolo. and Fish.

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Section: Discussionsupporting

confidence: 93%

Section: Discussionmentioning

confidence: 51%

Section: Introductionmentioning

confidence: 99%

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The ameliorative potential of the ethanol extract of the plant Ocimum basilicum on Biomphalaria alexandrina snails exposed to the insecticide Bestacid

Mossalem¹,

Ibrahim²

2019

Egypt. J. of Aquatic Biolo. and Fish.

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“…The above-mentioned present results illustrated that the exposed snails to sublethal concentration of miltefosine and artemether provoked DNA single strand breaks of B. alexandrina hemocytes. This finding was in agreement with the previous studies 11,29,[32][33][34] on synthetic chemical and natural drugs against B. alexandrina snails. Generally, genotoxicity refers to the efficacy of chemical or physiological or biological agents to trigger DNA damage 29 .…”

Section: Resultssupporting

confidence: 94%

“…In the present study, the evaluation of hemocytes denoted that S. mansoni infected snails had higher significant increase in hemocyte production comparable with treated-infected snail groups with miltefosine and artemether. These results confirmed with the findings of other researchers 23,28,29 .…”

Section: Resultssupporting

confidence: 93%

Sublethal toxicity of miltefosine and artemether to molecular aspect of Biomphalaria alexandrina snails

2019

jcbsc

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The present study was performed to elucidate the genotoxicity effect of sublethal concentration of miltefosine (8.20 ppm) as a synthetic molluscicidal agent and artemether (11.04 ppm) as plant molluscicidal agent against Biomphalaria alexandrina snails; vectors for transmitting Schistosoma mansoni infection to human. DNA changes of hemocytes of treated snails were studied by comet assay and the overall results showed that the miltefosine had more toxic effect than artemether against snails. The results also, demonstrated that both examined drugs induced a significant decrease in hemocytes count comparable with their corresponding controls. The drugs negatively affect DNA of hemocytes and appear as a potential inhibitor of DNA synthesis in snails. Consequently, in conclusion, the tested materials could be ranked as beneficial promising molluscicidal agents for the control program of schistosomiasis.

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Toxic, cytotoxic and genotoxic effect of plumbagin in the developmental stages of Biomphalaria glabrata (Say, 1818‐intermediate host) and cercaricidal activity against the infectious agent of schistosomiasis mansoni

França

Silva

Diniz

et al. 2022

Pest Management Science

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BACKGROUND: Snails of the genus Biomphalaria are intermediate hosts of Schistosoma mansoni, the main etiological agent of schistosomiasis mansoni, which affects about 236.6 million people in tropical and subtropical regions of the world. The World Health Organization recommends the population control of vector snails as one of the strategies to reduce the prevalence and incidence of schistosomiasis. In this study, molluscicidal and antiparasitic activities of plumbagin, a naturally sourced naphthoquinone with a range of biological effects, were evaluated against B. glabrata and cercariae of S. mansoni. RESULTS:After 24 h of exposure, plumbagin demonstrated molluscicidal activity at low concentrations against embryos (LC 50 of 0.56, 0.93, 0.68, 0.51 and 0.74 ∼g mL −1 for the blastula, gastrula, trochophore, veliger and hippo stage, respectively) and adult snails (LC 50 of 3.56 ∼g mL −1 ). There were no changes in exposed snails' fecundity or fertility; however, plumbagin was able to increase the frequency of DNA damage and the number of hemocytes, with apoptosis and binucleation being the main hemocyte alterations. In addition, plumbagin showed death of S. mansoni cercariae in the concentration of 1.5 ∼g mL −1 in 60 min, while showing moderate toxicity to Artemia salina.CONCLUSION: Plumbagin proved to be a promising substance for the control of B. glabrata population, intermediate host of S. mansoni, as well as the cercariae, infective stage for humans (definitive host), while being moderately toxic to A. salina, a crustacean widely used in ecotoxicity tests.

show abstract

Hematological, physiological and genotoxicological effects of Match 5% EC insecticide on Biomphalaria alexandrina snails

Cited by 38 publications

References 34 publications

The ameliorative potential of the ethanol extract of the plant Ocimum basilicum on Biomphalaria alexandrina snails exposed to the insecticide Bestacid

The ameliorative potential of the ethanol extract of the plant Ocimum basilicum on Biomphalaria alexandrina snails exposed to the insecticide Bestacid

Sublethal toxicity of miltefosine and artemether to molecular aspect of Biomphalaria alexandrina snails

Toxic, cytotoxic and genotoxic effect of plumbagin in the developmental stages of Biomphalaria glabrata (Say, 1818‐intermediate host) and cercaricidal activity against the infectious agent of schistosomiasis mansoni

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