Hematological manifestation in Down Syndrome

Ali, Tahani Ali Bin

doi:10.25141/2475-3432-2017-6.0165

Cited by 2 publications

(2 citation statements)

References 6 publications

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“…TAM is estimated to occur in approximately 10% of newborns with Down syndrome. Although it is transient, a small number develop serious or even fatal complications such as hepatic brosis or edema, and 20% of those who recover from TAM develop acute megakaryoblastic leukemia [5].…”

Section: Discussionmentioning

confidence: 99%

“…This chromosomal anomaly causes intellectual disability, speci c phenotypic characteristics, and a combination of systemic conditions [1,2]. Among the hematological alterations seen are leukemia, transient abnormal myelopoiesis, neutrophilia, and thrombocytopenia with giant platelets [3][4][5][6][7]. Macrocytosis, thrombocytosis, and leukopenia have been reported in older children [8,9].…”

Section: Introductionmentioning

confidence: 99%

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Blood Cytology in Children with Down Syndrome

Puente

Arizmendi

Tapia

et al. 2022

Preprint

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IntroductionDown syndrome is associated with various congenital anomalies and metabolic alterations such as hematological alterations. Values for the major hematological indicators vary with age and sex, but these values have not been described for Mexican children with Down syndrome.Objective. To describe the complete blood count (CBC) values of pediatric patients with Down syndrome and report the most common non-malignant hematological alterations. Materials and Methods.The analysis includes data from 450 patients with Down syndrome, 55.5% ware males, aged 0-18 years who were patients at the Mexican National Institute of Pediatrics and whose clinical charts included CBC panel results for the period January 2008 through March 2018. Results.A total of 3438 CBC panels were analyzed with descriptive statistics to find the values and statistical dispersion of the major indicators, with percentiles, and reported separately by sex and age group. The most common non-malignant hematological alterations found were macrocytic anemia, leukopenia, lymphopenia, and thrombocytosis. There were differences in values in all three series.Conclusions. The CBC panels and hematological alterations are summarized for patients with Down syndrome.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Blood Cytology in Children with Down Syndrome

Puente

Arizmendi

Tapia

et al. 2022

Preprint

View full text Add to dashboard Cite

show abstract

Blood cytology in children with down syndrome

Puente¹,

Guerrero-Tapia²,

Vargas-Robledo³

et al. 2022

BMC Pediatr

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Introduction Down syndrome is associated with various congenital anomalies and metabolic alterations such as hematological alterations. Values for the major hematological indicators vary with age and sex, but these values have not been described for Mexican children with Down syndrome. Objective To describe the complete blood count (CBC) values of pediatric patients with Down syndrome in México and report the most common non-malignant hematological alterations. Materials and methods The analysis includes data from 450 patients with Down syndrome, 55.5% ware males, aged 0-18 years who were patients at the Mexican National Institute of Pediatrics and whose clinical charts included CBC panel results for the period January 2008 through March 2018. Results A total of 3438 CBC panels were analyzed with descriptive statistics to find the values and statistical dispersion of the major indicators, with percentiles, and reported separately by sex and age group. The most common non-malignant hematological alterations found were macrocytic anemia, leukopenia, lymphopenia, and thrombocytosis. There were differences in values in all three series. Conclusions The CBC panels and hematological alterations are summarized for patients with Down syndrome.

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Hematological manifestation in Down Syndrome

Cited by 2 publications

References 6 publications

Blood Cytology in Children with Down Syndrome

Blood Cytology in Children with Down Syndrome

Blood cytology in children with down syndrome

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