IntroductionDown syndrome is associated with various congenital anomalies and metabolic alterations such as hematological alterations. Values for the major hematological indicators vary with age and sex, but these values have not been described for Mexican children with Down syndrome.Objective. To describe the complete blood count (CBC) values of pediatric patients with Down syndrome and report the most common non-malignant hematological alterations. Materials and Methods.The analysis includes data from 450 patients with Down syndrome, 55.5% ware males, aged 0-18 years who were patients at the Mexican National Institute of Pediatrics and whose clinical charts included CBC panel results for the period January 2008 through March 2018. Results.A total of 3438 CBC panels were analyzed with descriptive statistics to find the values and statistical dispersion of the major indicators, with percentiles, and reported separately by sex and age group. The most common non-malignant hematological alterations found were macrocytic anemia, leukopenia, lymphopenia, and thrombocytosis. There were differences in values in all three series.Conclusions. The CBC panels and hematological alterations are summarized for patients with Down syndrome.
The American Academy of Pediatrics have previously described comorbidities and health care recommendations in Down syndrome.This review was conducted of topics that have not been included in previously published recommendations or that require updating, this topics are: neonatal hyperbilirubinemia, thyroid dysfunction, deglutition disorders, immunity, vaccination, pulmonary hypertension, diabetes mellitus, dyslipidemias, hyperuricemia, vitamin D, oxidative stress, and autism. Method: Searches were performed with CINAHL, Medline, EMBASE, PsycINFO, PubMed, LILACS, RIMA and BNI and assessed for methodological quality using the Joanna Briggs Institute tool. Conclusions: The medical aspects presented in this articlecan help to the health care professionals to provide more effective care. The early detection of some comorbiditiescan improve prognosis and lower the cost of care for the complications then may cause.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.
hi@scite.ai
10624 S. Eastern Ave., Ste. A-614
Henderson, NV 89052, USA
Copyright © 2024 scite LLC. All rights reserved.
Made with 💙 for researchers
Part of the Research Solutions Family.