Hematological effects of injected gossypol and iron in rats

Tone, J. N.; Jensen, Dalan R.

doi:10.1021/jf60191a038

Cited by 9 publications

(4 citation statements)

References 9 publications

(11 reference statements)

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“…After 10 days treatment at the two higher doses, skin lesions appeared on the backs of some animals but none of the animals died. Other effects including hematological abnormalities, decreased iron and hemoglobin levels, and hypokalaemia have been reported in the literature in response to high levels of gossypol (Tone & Jensen 1974;Skutches et al 1974) but were not monitored in this study.…”

Section: Methodsmentioning

confidence: 87%

Short Term Metabolic Effects of the Anti‐Fertility Agent, Gossypol, on Various Reproductive Organs of Male Mice

1980

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In order to evaluate the short term metabolic effects of gossypol on the testes as well as any possible effects on the secondary sex organs, Balb C mice were injected subcutaneously with various doses of gossypol (0.25-25.0 mg/kg body weight) in corn oil for 10 days. Wet weights of several different secondary sex reproductive organs decreased during gossypol treatment. However, wet weights of the testes during treatment remained equal to or greater than control values. Following 10 days of gossypol treatment, incorporation of [3H]thymidine or [3H]amino acids into trichloroacetic acid precipitable macromolecules was inhibited in the seminal vesicles and ventral prostates normalized to either DNA or wet weight. Treatment with gossypol also had an inhibitory effect on epididymal sperm count at the two highest doses. These results demonstrate that gossypol will decrease sperm count at high dose levels after treatment of male mice for as short as 10 days. However, its overall effects are not limited to the testes and spermatogenesis but, in addition, it has dramatic inhibitory effects on protein and nuclei acid metabolism in the secondary sex organs.

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Section: Methodsmentioning

confidence: 87%

Short Term Metabolic Effects of the Anti‐Fertility Agent, Gossypol, on Various Reproductive Organs of Male Mice

1980

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“…These parameters fell to below normal values by day 14. Iron injection showed a normal erythrocyte population in rats treated with gossypol (Tone and Jensen, 1974). When hamsters inhaled gossypol in aerosol form (in sterile deionized water at concentrations of 0.1-1.0mg/l00ml) it caused damage to the epithelial cells of the airway all the way to the respiratory bronchioles.…”

Section: Signs Of Toxicitymentioning

confidence: 96%

“…Iron dextran injected into the peritoneal cavity of the rat simultaneously with corn oil containing gossypol was partially effective in preventing the growth depression resulting from the injected gossypol (Clawson et al, 1962). When iron was injected with gossypol in rats, the animals showed a normal erythrocyte population whereas gossypol alone showed an increase in erythrocytes (Tone and Jensen, 1974). Gossypol reduces the uptake of iron by everted segments of rat duodenum when it is present with the iron simultaneously in the mucosal medium (Herman and Smith, 1975).…”

Section: Gossypol Interaction With Protein Iron and Other Componentsmentioning

confidence: 99%

“…It was shown that increasing the level of bound gossypol from 0.45 to 1.3% required an increase in the level of dietary protein of approximately 4% to produce approximately the same rate of gain in weanling rats (Smith, 1972). Accumulations of gossypol in the livers of rats injected with gossypol were found and attributed to its binding with protein (Tone and Jensen, 1974). Gossypol reduced the serum iron-binding capacity and total serum protein by approximately 20% when pigs were fed a diet containing 0.06% free gossypol for 43 days (Skutches et al, 1974).…”

Section: Gossypol Interaction With Protein Iron and Other Componentsmentioning

confidence: 99%

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