Hematological Complications of Alcoholism

Ballard, Harold S.

doi:10.1111/j.1530-0277.1989.tb00408.x

Cited by 175 publications

(208 citation statements)

References 74 publications

(2 reference statements)

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“…Other nutritional anemias in alcoholics are iron deficiency anemia (often occurring) and acute spherocytic hemolytic anemia (less common) (23). The excessive alcohol consumption reduces the number of RBCs, because of direct toxic effects of alcohol including interference with maturation of them in the bone marrow (21). In our study, we also observed a decrease in the number of red blood cells in up to 64% of alcoholics.…”

Section: Discussionsupporting

confidence: 70%

“…Alcohol may cause this type of anemia by direct interference with heme synthesis. Abstinence can reverse this effect and changed sideroblasts can disappear from bone marrow within 5 to 10 d, and RBC production resume (21). Other nutritional anemias in alcoholics are iron deficiency anemia (often occurring) and acute spherocytic hemolytic anemia (less common) (23).…”

Section: Discussionmentioning

confidence: 99%

“…We suppose that the remaining 8% of patients may have macrocytic or other types of anemia. For example, sideroblastic anemia is a common complication in severe alcoholics and approximately one-third of these patients have ringed sideroblasts in their bone marrow (21). Generally, sideroblastic anemia occurs in 29 to 31% of alcoholics (22).…”

Section: Discussionmentioning

confidence: 99%

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The Distribution of Serum Folate Concentration and Red Blood Cell Indices in Alcoholics

Cylwik

Naklicki

Gruszewska

et al. 2013

J Nutr Sci Vitaminol

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Summary Chronic alcohol consumption leads to malnutrition and to the deficiency of many vitamins. One of the most important is folate deficiency. Folate deficiency disrupts the process of hematopoiesis, which can be evaluated by the changes of red cell indices. The aim of this study was to determine the hematological disturbances by the measurement of red blood cell indices in a Polish population of chronic alcoholics according to folate status. We studied 80 consecutive chronic alcoholic men and 30 healthy controls. Patients were divided into 2 groups according to the folate concentration. The serum folate and vitamin B12 concentration and the blood count were determined. We have shown that the serum folate concentration was decreased in 40% of alcoholics, but there was no folate deficiency and the level of vitamin B12 was normal. There was no correlation between folate, vitamin B12 and hematological indices. We have observed that most hematological parameters (Hb, RBCs, and Hct) in alcoholics were decreased and only two of them (MCV and MCHC) were increased in comparison with the controls. We observed no significant correlation between the RBCs indices and the weekly alcohol intake, but the correlation between RBCs, Hb, Hct and the duration of dependence have been shown. We concluded that, there is no folate deficiency in the Polish alcoholic population but the abusers with low folate levels may already have some RBCs indices affected. It means that the Polish alcoholic population consumes a sufficient amount of vitamins, which prevents the occurrence of hematological disturbances.

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Section: Discussionsupporting

confidence: 70%

Section: Discussionmentioning

confidence: 99%

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The Distribution of Serum Folate Concentration and Red Blood Cell Indices in Alcoholics

Cylwik

Naklicki

Gruszewska

et al. 2013

J Nutr Sci Vitaminol

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“…3,4 Large amounts of alcohol are known to increase blood pressure however different drinking habits seem to have different effects on blood pressure. 5 It was reported that there is a level of alcohol consumption, of approximately four drinks per day, below which drinkers have either similar or lower blood pressure levels compared to nondrinkers.…”

Section: Introductionmentioning

confidence: 99%

A study on comparison of hematological, autonomic and respiratory parameters in male drinkers and non-drinkers of Karukutty village, Kerala

Kumar¹,

Angel²,

Mathew³

et al. 2013

Comm. Based Med J

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. AbstractThe present study was undertaken to compare hematological, autonomic and respiratory parameters in male drinkers and non-drinkers to create awareness and to popularize the knowledge of good/bad effects of drinking. Two hundred and twenty two males with mean age 32±4 were involved in this study comprising of 110 chronic drinkers and 112 non-drinkers, who served as controls. Bleeding time was estimated by Duke Method clotting time was estimated by capillary tube method. Measurement of blood pressure was performed by using sphygmomanometry. Pulse Oximeter was used to measure saturation of hemoglobin (SPo 2) and pulse rate. The analysis of data was done by SPSS 20.0. Mean bleeding time was higher in drinkers than non-drinkers. In contrast Clotting time was lower in drinkers. Systolic and diastolic pressure was almost equal in drinkers and non-drinkers. Pulse rate was slightly higher in drinkers than non-drinkers. SPo 2 was equal in both drinkers and non-drinkers. We conclude that alcohol prolongs bleeding time and shortens clotting time, however this is contradictory. Alcohol enhances pulse rate may be by decreasing vagal activity and increasing sympathetic activity. Though alcohol causes vasodilation, we haven't observed any change in blood pressure.Inspite of the fact alcohol consumption effects Spo2, no change is observed in spo2 in our study. Hence this study merits continuing with higher sample size.

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“…In addition, alcohol can interfere with the production and function of WBCs that defend against infections by decreasing the ability of neutrophils to bind, ingest and kill bacteria and reduce lymphocytic antibody production, as well as causing a direct toxicity on macrophages and monocytes in the BM. 5,6 Excessive alcohol use can result in thrombocytopenia due to an indirect effect of liver damage, which decreases the number of factors that are necessary for platelet formation. 6 Excessive and chronic alcohol use also puts patients at risk for additional medical comorbidities.…”

mentioning

confidence: 99%

Patients at risk: addressing addiction in patients undergoing hematopoietic SCT

Stagno

Busby

Shapiro

et al. 2008

Bone Marrow Transplant

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Addictive disorders are common and underdiagnosed in the general medical population. While it is well recognized that alcohol consumption is linked to cancers of the head and neck as well as the large bowel, its association with cancers for which hematopoietic SCT (HSCT) is a modality of treatment is not as clear. Further, the complications of alcohol or other drug addiction in patients undergoing HSCT has not been well studied. However, patients with comorbid substance use disorders (SUDs) are at higher risk for morbidity and mortality while undergoing HSCT due to medical sequelae of SUDs and issues of social support, adherence to treatment plans, and impairment of judgment and decision-making. Behavioral patterns of patients with SUDs are clearly relevant factors to consider in patient selection, management and outcome. We offer a review of the existing literature and recommendations for assessment and management of this patient population.

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Hematological Complications of Alcoholism

Cited by 175 publications

References 74 publications

The Distribution of Serum Folate Concentration and Red Blood Cell Indices in Alcoholics

The Distribution of Serum Folate Concentration and Red Blood Cell Indices in Alcoholics

A study on comparison of hematological, autonomic and respiratory parameters in male drinkers and non-drinkers of Karukutty village, Kerala

Patients at risk: addressing addiction in patients undergoing hematopoietic SCT

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