Objective To evaluate whether a fixed dose combination (FDC) with remogliflozin and vildagliptin as an add-on therapy can improve the glycemic control in the management of type 2 diabetes mellitus and also the non-glycemic effects on physical profile, blood pressure, lipids, and insulin resistance. Materials and Methods An observational study that included 50 poorly controlled diabetics from April 2021 to September 2021. Patients were divided into two groups – those who were prescribed this FDC by their treating physician as an add-on drug were formed as group 1 ( n = 28). Comparison group was age-matched patients who received other standard anti-diabetic medications, categorized as group 2 ( n = 22). Fasting and postprandial sugars were done at baseline, the third and sixth month; glycated hemoglobin, body mass index, blood pressure, and lipids were done at baseline and the sixth month. Changes in blood sugar levels and glycated hemoglobin (HbA1C) at the third and sixth month from the baseline were compared using the Mann-Whitney U test. P-value less than 5% was considered statistically significant. Results A statistically significant reduction in mean HbA1c was noted in group 1 [–1.80 (−3.20, −0.15)] when compared to group 2 [0.50 (0.05, 0.80)] at the end of the third month. At the end of the sixth month, a significant reduction in the HbA1c level was noted in group 1 [(7.83 ± 0.87 %) when compared to baseline (10.3 ± 1.75%)]. Change in PPBS value at the third month from baseline was also statistically significant between groups 1 and 2 (−62.0 mg%, 19.0, P = 0.003). With respect to the body mass index and blood pressure, we did not find any significant difference. Conclusion The fixed drug combination improves glycemic control by significantly reducing mean HbA1c at the third and sixth month from baseline and there was no significant effect on body mass index, blood pressure, and lipids.
Background: Cardiovascular disease is one of the leading causes of mortality and morbidity in India and worldwide. Hypertension is a major public health problem because of its high frequency and concomitant risk of cardiovascular disease, kidney disease, and stroke. World Health Organization named it a Silent killer as hypertension is asymptomatic during its clinical course. Experimental evidence supports a role for oxidative stress in vascular injury and hypertension. This study was undertaken, to compare the serum levels of malondialdehyde (MDA) and super-oxide dismutase (SOD) among normotensive, prehypertensive and hypertensive subjects. Materials and methods: In this cross-sectional study, 34 normotensives, 44 prehypertensive and 45 hypertensive subjects were included. The participants were subjected to selection protocol consisting of physical examination and biochemical analysis. All subjects underwent blood pressure measurement, total cholesterol, and oxidative stress marker estimation, especially SOD and MDA. The comparison of parameters between the group was carried out using One Way ANOVA. The correlation between the parameter was analyzed by Karl Pearson Correlation Coefficient using SPSS 20.0. Result : The MDA (nmol/ml) in normotensive, prehypertensive and hypertensive patients was 2.55±0.072, 3.43±0.44 and 4.01±0.37 respectively. SOD (U/ml) level in normotensive, prehypertensive and hypertensive patients was 13.47±1.96, 11.57±0.81, and 8.52±1.78 respectively. Systolic and diastolic blood pressure had a negative correlation with SOD. MDA levels show a positive correlation with systolic blood pressure and diastolic blood pressure. Total cholesterol had no significant with SOD and MDA. Conclusion: The present study showed a strong association of oxidative stress with systolic and diastolic blood pressure.
. AbstractThe present study was undertaken to compare hematological, autonomic and respiratory parameters in male drinkers and non-drinkers to create awareness and to popularize the knowledge of good/bad effects of drinking. Two hundred and twenty two males with mean age 32±4 were involved in this study comprising of 110 chronic drinkers and 112 non-drinkers, who served as controls. Bleeding time was estimated by Duke Method clotting time was estimated by capillary tube method. Measurement of blood pressure was performed by using sphygmomanometry. Pulse Oximeter was used to measure saturation of hemoglobin (SPo 2) and pulse rate. The analysis of data was done by SPSS 20.0. Mean bleeding time was higher in drinkers than non-drinkers. In contrast Clotting time was lower in drinkers. Systolic and diastolic pressure was almost equal in drinkers and non-drinkers. Pulse rate was slightly higher in drinkers than non-drinkers. SPo 2 was equal in both drinkers and non-drinkers. We conclude that alcohol prolongs bleeding time and shortens clotting time, however this is contradictory. Alcohol enhances pulse rate may be by decreasing vagal activity and increasing sympathetic activity. Though alcohol causes vasodilation, we haven't observed any change in blood pressure.Inspite of the fact alcohol consumption effects Spo2, no change is observed in spo2 in our study. Hence this study merits continuing with higher sample size.
Objective : Cardiovascular disease is amenable to mortality and morbidity in India and worldwide. The asymptomatic nature of hypertension made it a silent killer. Evidence suggests the role of oxidative stress and anxiety in the pathogenesis of hypertension. Lifestyle modification can control hypertension and, thus, can prevent complications. Music therapy is a non-invasive, non-pharmacological, and economic practice used for the management of hypertension, anxiety, and oxidative stress. The present study aims to evaluate the therapeutic effect of Raga Ananda Bhairavi on oxidative stress and anxiety in hypertensive patients. Materials and Methods: This randomized control study comprises of a total of 120 participants of age between 30-60years. All the study participants were divided into an experimental and control group. The instrumental music of Raga Ananda Bhairavi was provided to the experimental group for three months. The anthropometric measurements, blood pressure assessment, and estimation of oxidative stress parameters were done in all subjects before and after three months of intervention. Results: The systolic blood pressure, diastolic blood pressure, anxiety levels, and oxidative stress marker malondialdehyde significantly reduced after music therapy, and the superoxide dismutase level significantly improved after the intervention. Conclusion: Music can be used as an adjunct therapy for the management of hypertension.
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