Hematological and Biochemical Alterations in Occupationally Pesticides-Exposed Workers of Riyadh Municipality, Kingdom of Saudi Arabia

Al‐Sarar, Ali S.; Bakr, Y. A.; Al-Erimah, G. S.; Hussein, Heba A.; Bayoumi, A. E.

doi:10.3923/rjet.2009.179.185

Cited by 31 publications

(29 citation statements)

References 24 publications

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“…Pesticide production workers, applicators, and farmers are the main risk groups of high-dose exposure; however, the common population is exposed to lower doses via the contaminated food and water or during the household use. It was documented that the exposure to low doses of pesticides produces various biochemical alterations leading to adverse health effects in the exposed organisms (Banerjee et al 1999;Al-Sarar et al 2009.…”

Section: Introductionmentioning

confidence: 99%

Cytotoxic and genotoxic effects of abamectin, chlorfenapyr, and imidacloprid on CHOK1 cells

Al‐Sarar

Abobakr

Bayoumi

et al. 2015

Environ Sci Pollut Res

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The cytotoxicity and genotoxicity of abamectin, chlorfenapyr, and imidacloprid have been evaluated on the Chinese hamster ovary (CHOK1) cells. Neutral red incorporation (NRI), total cellular protein content (TCP), and methyl tetrazolium (MTT) assays were followed to estimate the mid-point cytotoxicity values, NRI50, TCP50, and MTT50, respectively. The effects of the sublethal concentration (NRI25) on glutathione S-transferase (GST), glutathione reductase (GRD), glutathione peroxidase (GPX), and total glutathione content have been evaluated in the presence and absence of reduced glutathione (GSH), vitamin C, and vitamin E. The genotoxicity was evaluated using chromosomal aberrations (CA), micronucleus (MN) formation, and DNA fragmentation techniques in the presence and absence of the metabolic activation system, S9 mix. Abamectin was the most cytotoxic pesticide followed by chlorfenapyr, while imidacloprid was the least cytotoxic one. The glutathione redox cycle components were altered by the tested pesticides in the absence and presence of the tested antioxidants. The results of genotoxicity indicate that abamectin, chlorfenapyr, and imidacloprid have potential genotoxic effects on CHOK1 cells under the experimental conditions.

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Section: Introductionmentioning

confidence: 99%

Cytotoxic and genotoxic effects of abamectin, chlorfenapyr, and imidacloprid on CHOK1 cells

Al‐Sarar

Abobakr

Bayoumi

et al. 2015

Environ Sci Pollut Res

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“…In some of the experimental and clinical studies, it has been reported that all these parameters remain unchanged in organophosphate poisoning, whereas in other studies, it has been shown that MCH and MCHC values remain unchanged and Hb and MCV values decrease (19)(20)(21). The expected blood picture is severe anemia in organophosphate poisoning because of the shortened lifespan of erythrocytes and inhibited Hb synthesis by organophosphates.…”

Section: Discussionmentioning

confidence: 99%

“…A clinical study reported that RDW levels remain unchanged in patients with low-dose organophosphate poisoning (20). In one study in which morphological evaluation of the blood cells of organophosphate-poisoned rats was performed using scanning electron microscope, it was reported that most of the cells changed to stomatocytes or spherocytes, and increased anisocytosis was a prominent feature (22).…”

Section: Mechanically Ventilatedmentioning

confidence: 99%

“…Two major mechanisms in acute organophosphate poisoning, cholinergic syndrome and increased oxidative stress, lead to increased leukocyte counts in the body. Experimental and clinical studies have reported that leukocyte counts are increased in organophosphate poisoning (3,10,20,21). In a few clinical studies, it was reported that leukocytosis could be used as a prognostic parameter for predicting the severity of organophosphate poisoning (3,23,24).…”

Section: Mechanically Ventilatedmentioning

confidence: 99%

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Prognostic Value of Red Cell Distribution Width in Patients with Organophosphate Poisoning

Dündar¹,

Köylü²,

Ergin³

et al. 2015

JAEM

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Aim: The aim of this retrospective study was to investigate the prognostic value of red cell distribution width (RDW) and other hematological parameters measured on admission to the emergency department in patients with organophosphate poisoning. Materials and Methods:All patients aged ≥15 years who were admitted to the emergency department from 2008 to 2013 on account of organophosphate poisoning were included in the study. The written and electronic medical charts of the patients were reviewed. Hematological parameters were recorded. Mechanical ventilation requirement was used as the primary endpoint.Results: A total of 72 patients were included in the study for evaluation. Mechanically ventilated patients had significantly higher leukocyte counts and RDW levels than non-ventilated patients (p=0.004 and p<0.001, respectively). The area under the receiver-operating characteristic curve of RDW levels for predicting mechanical ventilation requirement was 0.716 (95% CI: 0.581-0.852, p=0.010). RDW had a sensitivity of 73%, specificity of 70%, and negative predictive value of 91% with a cut-off value of 14.5% in predicting mechanical ventilation requirement in patients with organophosphate poisoning. Conclusion:RDW can be a valuable and easy-to-use parameter in estimating prognosis in the follow-up of patients with organophosphate poisoning. (JAEM 2015; 14: 65-9)

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“…These findings are in agreement with a number of previously reported similar stu dies. [26][27][28][29][30] A recent study, using mice as a model animal, revealed that deltamethrin (a synthetic pyrethroidpesticide) caused decrease in total proteins. 31 The dec-180 rease of serum proteins, especially albumin, might be due to alteration in protein metabolism of free amino acids and their production in liver under the influence of pesticides.…”

Section: Discussionmentioning

confidence: 99%

Chemical Biomarker Study of Negative Physiological Effects of Insecticides on Pakistani Farm Workers Health in the Central Punjab

Shahzad¹,

Yaqub²,

Shaukat³

et al. 2016

Annals KEMU

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Background: In recent decades, use of pesticides in agricultural practices has posed threat to human population. Objectives: Present research was designed to explore the adverse effects of insecticides on 339 individuals (study group farmers n = 256 and control n = 83) selected from 62 different sites of central Punjab. The sample was matched on socio-economic status and age. Methodology: A structured questionnaire was used to

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Hematological and Biochemical Alterations in Occupationally Pesticides-Exposed Workers of Riyadh Municipality, Kingdom of Saudi Arabia

Cited by 31 publications

References 24 publications

Cytotoxic and genotoxic effects of abamectin, chlorfenapyr, and imidacloprid on CHOK1 cells

Cytotoxic and genotoxic effects of abamectin, chlorfenapyr, and imidacloprid on CHOK1 cells

Prognostic Value of Red Cell Distribution Width in Patients with Organophosphate Poisoning

Chemical Biomarker Study of Negative Physiological Effects of Insecticides on Pakistani Farm Workers Health in the Central Punjab

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