Hematologic-Related Malignancy-Induced Eosinophilic Dermatosis (He Remained): An eosinophilic dermatosis predominantly associated with chronic lymphocytic leukemia

Insect bite-like reaction in a patient with T-cell lymphoma

“…To date, 206 IBLR cases have been reported, and only two cases were associated with hematologic malignant neoplasms of T-cell origin. 2 Therefore, our case is the third report of IBLR associated with T-cell lymphoma. However, it is not yet clear why most IBLR cases are associated with hematologic malignant neoplasms derived from B cells.…”

“… 1 Hematologic malignant neoplasms are derived from B cells in most cases. 2 We herein describe a rare case of IBLR in Anaplastic Large Cell Lymphoma (ALCL) patient, a type of T-cell lymphoma. To our knowledge, this is the third report of IBLR associated with T-cell lymphoma.…”

Long-term maintenance of eosinophilic dermatosis of hematologic malignancy with doxycycline

“…Although its pathogenesis has not been fully elucidated, EDHM is likely driven by an induced cytokine imbalance caused by neoplastic leukemic B cells with increased production of interleukin 4 and interleukin 5 by Th-2 cells, which are largely responsible for the recruitment of eosinophils. 1 , 3 , 7 In some reported cases, however, improvement with chemotherapy was noted but the disease often recurred. 2 , 8…”

“…It is characterized as a nonspecific pruritic eruption with pleomorphic clinical presentations ranging from erythematous, urticarial papules and nodules to vesicles and bullae, making accurate diagnosis difficult, as it can mimic other conditions. 1 EDHM often has a chronic, recurrent course with differential responses to treatment modalities reported in the literature. 2 We report two cases of EDHM that initially were a diagnostic and therapeutic challenge; we hope to raise awareness of this rare entity as well as share a successful long-term treatment regimen not previously reported.…”

Immune-Mediated Dermatoses in Patients with Haematological Malignancies: A Comprehensive Review

“…As previously mentioned, different names have been proposed across the years, including exaggerated arthropod bite reactions, insect bite-like reactions and eosinophilic dermatoses of myeloproliferative diseases [124,125]. More recently, the acronym "He Remained" (Haematologic Related Malignancy-Induced Eosinophilic Dermatoses) has been also proposed to highlight the pathogenetic link between skin manifestations and the presence of the HM [128]. A potential consequence of having a large number of names for the same condition is that they can generate much confusion among clinicians [125].…”