Long-term maintenance of eosinophilic dermatosis of hematologic malignancy with doxycycline

Mieczkowska, Karolina; Rzepecki, Alexandra K.; Jacob, Jack; Amin, Bijal; Jacobson, Mark; McLellan, Beth N.

doi:10.1016/j.jdcr.2021.08.003

Cited by 5 publications

(1 citation statement)

References 9 publications

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“…Histopathologically, the lesions of EDHM are characterized by a superficial and deep dense perivascular infiltrate of small lymphocytes, accompanied by numerous eosinophils, with periadnexal distribution of the infiltrate often observed [5,11,12,30,31]. However, the literature regarding dermatopathology of EDHM is scarce and comprehensive studies are lacking [2,4,5,[11][12][13][14][15][16]22,[27][28][29]32,33].…”

Section: Introductionmentioning

confidence: 99%

Eosinophilic Dermatosis of Hematologic Malignancy: Emerging Evidence for the Role of Insect Bites—A Retrospective Clinico-Pathological Study of 35 Cases

Michelerio,

Rubatto,

Roccuzzo

et al. 2024

JCM

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Background/Objectives: Eosinophilic dermatosis of hematologic malignancy (EDHM) is a rare cutaneous disorder associated with various hematologic malignancies, most commonly chronic lymphocytic leukemia. Detailed clinicopathologic studies of EDHM are lacking and the pathogenesis remains enigmatic. Initially thought to be a hypersensitivity reaction to insect stings, subsequent reports have challenged this understanding. The prognostic implications of EDHM remain unclear. Methods: A retrospective clinicopathologic study was performed on patients diagnosed with EDHM. Hematologic and dermatologic data were reviewed. Histologic specimens were re-evaluated and lesions were classified into acute/subacute, fully developed, and chronic/regressing. Results: The study included 35 patients. In 80% of these patients, EDHM was diagnosed after the hematologic disorder. Approximately 45% of the cohort experienced hematologic disease progression or relapse, while 65% required therapeutic intervention during the course of their hematologic disease. In total, 15/19 CLL patients had non-mutated IgHV, a marker of a more aggressive hematologic disease course. Dermatologic lesion morphology was heterogeneous, with most lesions occurring on exposed areas, and a significant 94% of patients demonstrated lesion seasonality. Histopathologic findings were consistent with features typically associated with insect bites. In addition, examination of lesions at different chronological stages revealed substantial similarities with Wells syndrome. Conclusions: Our findings support the potential role of insect bites in triggering EDHM in the context of adaptive immune dysfunction. EDHM may be associated with a more aggressive disease course or may be a marker of disease progression. The observed co-occurrence of features typical of Wells syndrome in EDHM patients suggests that these conditions are part of a spectrum of disorders that vary in clinical expression.

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Section: Introductionmentioning

confidence: 99%

Eosinophilic Dermatosis of Hematologic Malignancy: Emerging Evidence for the Role of Insect Bites—A Retrospective Clinico-Pathological Study of 35 Cases

Michelerio,

Rubatto,

Roccuzzo

et al. 2024

JCM

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Multiple drugs

2022

Reactions Weekly

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A systematic review of the management of eosinophilic dermatosis of hematological malignancy

Tan,

Choong,

Tan

2024

Int J Dermatology

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Eosinophilic dermatosis of hematologic malignancy (EDHM) is a cutaneous manifestation seen in patients with hematoproliferative and lymphoproliferative disorders, most commonly chronic lymphocytic leukemia. This systematic review aimed to summarize the therapeutic interventions of EDHM. A comprehensive search yielded 71 studies, predominantly case reports and series. The most frequently reported modalities were systemic and topical corticosteroids, as well as treatment of the underlying malignancy. Responses to these treatments varied. Targeted therapies, including dupilumab and omalizumab, showed promise, as did other modalities such as montelukast, dapsone, doxycycline, and phototherapy. Higher‐quality studies should be conducted to facilitate higher‐quality management recommendations for EDHM.

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Long-term maintenance of eosinophilic dermatosis of hematologic malignancy with doxycycline

Cited by 5 publications

References 9 publications

Eosinophilic Dermatosis of Hematologic Malignancy: Emerging Evidence for the Role of Insect Bites—A Retrospective Clinico-Pathological Study of 35 Cases

Eosinophilic Dermatosis of Hematologic Malignancy: Emerging Evidence for the Role of Insect Bites—A Retrospective Clinico-Pathological Study of 35 Cases

Multiple drugs

A systematic review of the management of eosinophilic dermatosis of hematological malignancy

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