Hematobiochemical changes of lead Poisoning and amelioration with Ocimum sanctum in wistar albino rats

Sujatha, Karamala; ch, Sri; Anjaneyulu, Y.; TS, Chandra; Pidugu, Sreeni

doi:10.5455/vetworld.4.260

Cited by 21 publications

(15 citation statements)

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“…On contrary, Shrivastava (2011), Bhadauria (2012 showed that triglycerides levels were higher in the lead and aluminum treated group compared to the control group. Moreover, serum glucose level showed a significant decrease in lead treated groups in a dose dependent manner and not affected by aluminum treatment that agrees with Karamala et al (2011) andHassan et al (2008). This hypoglycemia might be due to the dysfunction of liver as the decrease in glucose-6-phosphatase activity indicates decrease degradation of glycogen, which may result in a subsequent decrease in blood glucose level (Gouda et al, 1985).…”

Section: Discussionsupporting

confidence: 90%

“…Furthermore, Sadhana et al (2008) showed that aluminum generates oxidative stress in kidney which caused significantly rise in the activity of uric acid. On contrary to this, Karamala et al (2011), Shrivastava (2011 and Sadhana et al (2008) reported that lead acetate and aluminum administration resulted in an increase in serum Creatinine and urea.…”

Section: Advances In Animal and Veterinary Sciencesmentioning

confidence: 87%

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Impact of Some Heavy Metals Toxicity on Behaviour, Biochemical and Histopathological Alterations in Adult Rats

Goma¹,

Tohamy²

2016

Adv. Anim. Vet. Sci.

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A nimal welfare is an issue not only for veterinary science and animal psychology but also for biochemical, agriculture, zoology and companion animal fields because animal welfare is a socially constructed idea and it is not a permanently fixed idea (Watanabe, 2007). On the other hand, animals are very good indicator of environmental pollution as they inhabit the same space as human and exposed to action of the same pollutants, for that reason it is appropriate and advantageous to evaluate the negative impact of the polluted environment by heavy metals on human health by parallel evaluation of their load on animals (Kozak et al., 2002).Lead is a one of the major heavy metals known to be toxic to mammals. It had many sources as metallic lead present in storage batteries, paints and rubbish dumps in areas near lead industrial establishments and also from the industrial applications especially the addition of vast quantities of research Article Abstract | Animal welfare is a matter of societal concern and debate, its improvement should consider those aspects actually affecting animal's health, through determining their impact on some welfare indicators, so, this study was conducted to investigate the effect of heavy metals toxicity on behavioural, biochemical and histopathological changes in adult rats. Twenty-five Sprague-Dawley adult rats were allotted into five groups, each of 5, two groups (GA & GB) treated with lead acetate (low 1g/l & high 2g/l) and another two (GC & GD) treated with anhydrous aluminium chloride (low 2 g/l & high 3.5 g/l) in drinking water daily for 5 weeks, while, GE (control) received drinking water without any treatment. The findings obtained indicated that feeding time, drinking, cage and total exploration frequencies increased in GB than other groups, although, lying time decreased. However, the movement activities increased in GA than others. On the other hand, glucose level decreased significantly in GB than GD and control. Furthermore, triglycerides and total lipid levels were significantly decreased in all treated groups than control. It was also revealed that the serum ALT increased significantly in GB than other groups while creatinine decreased significantly in both groups (GA & GB) treated with lead acetate than other groups with most decrement in high dose group of lead acetate. However, the urea level decreased and uric acid increased significantly in all treated groups than control. Microscopically, degenerated and necrotic hepatocytes, tubular and glomerulus's necrosis were observed in all toxicated rats beside eosinophilic intranuclear inclusions in lining epithelium of some renal tubules of lead toxicated rats. Therefore, it can be concluded that different toxic levels of lead acetate and aluminum chloride can affect animal's welfare by behavioural, biochemical and histopathological alterations in a dose dependent manner. Keywords

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Section: Discussionsupporting

confidence: 90%

Section: Advances In Animal and Veterinary Sciencesmentioning

confidence: 87%

Impact of Some Heavy Metals Toxicity on Behaviour, Biochemical and Histopathological Alterations in Adult Rats

Goma¹,

Tohamy²

2016

Adv. Anim. Vet. Sci.

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“…Pb is a metallic element that emanates into the environment from various sources, including the industrial waste, combustion of fossil fuels, and the use of agrochemicals. Higher levels of Pb cause a variety of acute and chronic health problems, including cancer, kidney damage, heart problems, and even death [54].…”

Section: Discussionmentioning

confidence: 99%

Nutritional Content and Elemental and Phytochemical Analyses ofMoringa oleiferaGrown in Mexico

Valdez-Solana

Mejía-García

Téllez‐Valencia

et al. 2015

Journal of Chemistry

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Moringa oleiferais a tree distributed in Mexican semiarid and coastal regions.M. oleiferais used in practice in the treatment of various diseases and is available without a medical prescription, often in the form of an herbal infusion for everyday use. The aim of the present study was to evaluate the chemical composition and nutritional values of driedM. oleiferaleaf powder collected from two different regions in Mexico. All samples ofM. oleiferaexhibited moisture levels varying from 3.06 to 3.34%, lipids from 10.21 to 10.31%, fiber from 7.29 to 9.46%, ashes from 10.71 to 11.18%, crude protein from 10.74 to 11.48%, and carbohydrates from 54.61 to 57.61%. The predominant mineral elements in the leaf powder according to ICP-MS were Ca (2016.5–2620.5 mg/100 g), K (1817–1845 mg/100 g), and Mg (322.5–340.6 mg/100 g). The HPLC analysis indicated the presence of phenolic acids (gallic and chlorogenic acids) and flavonoids (rutin, luteolin, quercetin, apigenin, and kaempferol). We concluded that LombardiaM. oleiferasamples could be employed in edible and commercial applications. Our results showed that the highest mean value of As from the San Pedro samples exceeds the recommended level and may constitute a health hazard to consumers.

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“…In addition to protecting against toxic chemicals, tulsi has also been shown to protect against the toxic effects of heavy metals such as lead, arsenic, cadmium, chromium and mercury[ 29 30 31 ] and the toxic effects of radiation. [ 32 33 34 35 ] Tulsi exerts its radio-protective effects by scavenging free radicals and reducing the oxidative cellular and chromosomal damage induced by radiation,[ 33 36 37 38 ] thereby reducing organ damage and enhancing postradiation survival in experimental animals.…”

Section: Introductionmentioning

confidence: 99%

Tulsi - Ocimum sanctum: A herb for all reasons

Cohen

2014

J Ayurveda Integr Med

324

183

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The predominant cause of global morbidity and mortality is lifestyle-related chronic diseases, many of which can be addressed through Ayurveda with its focus on healthy lifestyle practices and regular consumption of adaptogenic herbs. Of all the herbs used within Ayurveda, tulsi (Ocimum sanctum Linn) is preeminent, and scientific research is now confirming its beneficial effects. There is mounting evidence that tulsi can address physical, chemical, metabolic and psychological stress through a unique combination of pharmacological actions. Tulsi has been found to protect organs and tissues against chemical stress from industrial pollutants and heavy metals, and physical stress from prolonged physical exertion, ischemia, physical restraint and exposure to cold and excessive noise. Tulsi has also been shown to counter metabolic stress through normalization of blood glucose, blood pressure and lipid levels, and psychological stress through positive effects on memory and cognitive function and through its anxiolytic and anti-depressant properties. Tulsi's broad-spectrum antimicrobial activity, which includes activity against a range of human and animal pathogens, suggests it can be used as a hand sanitizer, mouthwash and water purifier as well as in animal rearing, wound healing, the preservation of food stuffs and herbal raw materials and traveler's health. Cultivation of tulsi plants has both spiritual and practical significance that connects the grower to the creative powers of nature, and organic cultivation offers solutions for food security, rural poverty, hunger, environmental degradation and climate change. The use of tulsi in daily rituals is a testament to Ayurvedic wisdom and provides an example of ancient knowledge offering solutions to modern problems.

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Hematobiochemical changes of lead Poisoning and amelioration with Ocimum sanctum in wistar albino rats

Cited by 21 publications

References 4 publications

Impact of Some Heavy Metals Toxicity on Behaviour, Biochemical and Histopathological Alterations in Adult Rats

Impact of Some Heavy Metals Toxicity on Behaviour, Biochemical and Histopathological Alterations in Adult Rats

Nutritional Content and Elemental and Phytochemical Analyses ofMoringa oleiferaGrown in Mexico

Tulsi - Ocimum sanctum: A herb for all reasons

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