Hematinic effect of fruits of Opuntia elatior Mill. on phenylhydrazine-induced anemia in rats

Abstract

Introduction:The fruits of Opuntia elatior Mill. are known as prickly pear and folkloric use as hematinic, anti-inflammatory and antiasthmatic action. Previously, the fruit juice of prickly pear was evaluated in reversed anemia induced by HgCl2 in a dose dependant manner and present study revealed about its effect in acute hemolytic anemia.Aim:To evaluate the hematinic activity of fruits of Opuntia elatior Mill.Materials and Methods:The hematinic activity of an orally administered fruit juice was studied on phenylhydrazine (PHZ)-induced anemic rats. The hematological parameters such as hemoglobin (Hb) content, red blood cell (RBC), packed cell volume (PCV), and reticulocyte count were analyzed as indices of anemia.Results:PHZ altered the hematological parameters by hemolysis characterized by a decrease in Hb content, total RBC counts and PCV (P < 0.001) on day 3. The Hb content (g%) was significantly increased (P < 0.05) at day 7 in 10 and 15 ml/kg fruit juice treated rats, which was a good improvement compared to the standard.Conclusion:The speedy and progressive recovery of anemic rats responding to treatment of the O. elatior Mill. fruits may be due to increased erythropoiesis and/or antioxidant property of betacyanin.

Opuntia Elatior Mill.–its Phytochemistry and Pharmacological Properties-a Review

“…The Hb % was significantly increased (P<0.05) in fruit juice treated rats, compared to the standard. This might be due to increased erythropoiesis and/or antioxidant property of betacyanin [34,35]. In a study on carboplatin induced anemia, Opuntia Swarasa at dose levels 1.8 and 3.6 ml/kg showed a good percentage of recovery in haemoglobin, 19.66% and 36.99% respectively, in TRBC, 38.53% and 47.69% respectively, which is higher than the standard carboplatin treated group [36].…”

Formulation and antianaemic evaluation of the tablets containing Telfairia occidentalis aqueous leaf extract

“…and served as negative control, Group B was left untreated, Group C received 100 mg/kg of dried aqueous Telfairia occidentalis extract (TOLE) after suspension in distilled water, Group D received 100 mg/kg of FP per oral; the tablet was crushed and a preparation of 10 mg/kg was made in distilled water then a dose of 100 mg/kg was orally administered. Group E received 0.2 mg/kg ferrous sulphate per oral and served as the positive control; the tablet was crushed and dissolved in distilled water to obtain a concentration of 2 mg/mL according to the method of Chauhan et al, (2015). Oral administration was done using a gavage needle.…”

Comparative Study of Anti-Anemic Effect of Some Natural Food Supplements on Rats

“…Two billion people suffer from anemia worldwide and most of them have iron deficiency and hemolytic anemia due to toxicants and oxidants. About 70-80% of the world population, particularly in the developing countries, rely on nonconventional medicine like dietary supplements and herbal remedies in their primary healthcare [1].…”

“…Iron deficiency is a silent condition that causes anemia only when hemoglobin synthesis results impaired represents one of the major causes of anemia and affects around 20-30% of adults worldwide [1] The relationship between anemia and the severity of covid-19 pneumonia is that's; compare to patients without anemia, patients with anemia were more comorbidities and sever covid-19 illness, as well as higher mortality covid-19 patients with anemia were predisposed to more sever inflammatory responses, coagulation disorders and organs injuries [4].…”