Hemangioma-thrombocytopenia syndrome; a disseminated intravascular coagulopathy

Massive liver haemangioma causing Kasabach–Merritt syndrome in an adult

“…4 The process seems to be localised in the tumour rather than generalised, as suggested by previous studies, but it may be exacerbated by surgery or biopsies, extending into a more disseminated process, manifesting as further thrombocytopenia, anaemia or developing venous thrombosis. 5 In the few reported adult cases, the presenting symptoms include abdominal pain, increased mass size, disseminated intravascular coagulopathy, bleeding, fractures and high output cardiac failure. Owing to the rarity of this syndrome, no clear guidelines for management are available.…”

Hemostatic and hematological abnormalities in gain‐of‐function fps/fes transgenic mice are associated with the angiogenic phenotype

“…Vascular lesions such as hemangiomas have been frequently associated with hemostasis dysfunction and this led us to examine coagulative and fibrinolytic parameters in fps MF mice [31–37]. Intrinsic and extrinsic coagulation were measured using APTT and PT assays, respectively.…”