Hemagglutination by measles virus

Measles virus

“…In the continuous human cell lines, growth is generally more rapid, and the cytopathie effect occurs earlier. These results were confirmed by other workers (DeMeio and Gower, 1961 ;Rosano//, 1961 ;Rosen, 1961). The virus has also been adapted to suckling mice and suckling hamsters.…”

Methods of determining immunity, duration and character of immunity resulting from measles

“…The hemagglutination-inhibition test Gisela Enders-Ruekle : became available in 1960 when Peri@s and Chany (9) discovered the hemagglutinating activity of measles virus for monkey erythrocytes and the specific inhibition of this reaction by measles immune sera. The data include observations from various investigators (10,11,12,13,14,15,16,17) and from our own work (2,3,5,18). The fluorescent antibody and the agar-gel diffusion precipitation techniques are reserved for identifying measles virus antigens rather than for measuring the antibody content in sera.…”

Multiplication of measles virus in cell cultures.

“…Peries and Chany (95) described hemagglutination reaction of measles virus. Infective materials agglutinate erythrocytes from various species of monkeys, such as baboon (95, 109), rhesus (27,109,110), cynomolgus (109), patas (95, 109), and African green monkey (109), but not erythrocytes of sheep, chicken, guinea pig, rabbit, horse, hamster, mouse, rat, cat, cattle, and man (109). The reaction was found to be speifically inhibited by measles antiserum (27,95,109,110).…”

“…Infective materials agglutinate erythrocytes from various species of monkeys, such as baboon (95, 109), rhesus (27,109,110), cynomolgus (109), patas (95, 109), and African green monkey (109), but not erythrocytes of sheep, chicken, guinea pig, rabbit, horse, hamster, mouse, rat, cat, cattle, and man (109). The reaction was found to be speifically inhibited by measles antiserum (27,95,109,110). Measles hemagglutinin has been demonstrated in various cell culture systems, but no hemagglutinin was shown in chick fibroblast cultures, even though infective titers were as high as in the other systems which produced hemagglutinin (95,109).…”