Hemadsorption by Murine Tumors

Antibody-Mediated Hemadsorption by Tumor Tissues

“…By using a similar technique, it was found that sections of fibrosarcoma induced by methylcholanthrene in C3H mice would adsorb human, guinea pig and chicken red blood cells. Similar hemadsorption was also observed with primary cell cultures of the sarcoma [4], Sheep red blood cells, which were not adsorbed by the tumor sections, gave positive hemadsorption tests when they were sen sitized by anti-sheep erythrocyte serum of rabbit or murine origin prior to their addition to the tumor sections [5,6]. The purpose of the present study was to clarify the mechanism of this antibodymediated hemadsorption.…”

Anti-γ-GIobulin Factors in Serum and Tissue of Cancer Patients

“…This resembled the reaction of 'cytophilic' antibodies combining by their Fc fragments with macrophages or spleen cells [3]. Significantly, as in previous studies [9], we observed that sensitized erythrocytes also adhered to sections of normal spleens.…”

Hemadsorption by Herpes Simplex-Infected Cell Cultures

“…A similar hemadsorption phenomenon was ob served in studying cell cultures of the sarcoma (4). It was further demonstrated that sheep erythrocytes, which were negative in these experiments, gave positive hemadsorption tests with either sections or cultures of murine sarcoma, if they were used following sensitiza tion by anti-sheep erythrocyte serum of rabbit or murine origin (5,6). These studies have been extended and will be described in a separate publication.…”

“…In following this line of investigation, it was demonstrated that sections of methylcholanthrcne-induced murine sarcoma would adsorb human, guinea pig and chicken, but not sheep or bovine erythrocytes (4). A similar hemadsorption phenomenon was ob served in studying cell cultures of the sarcoma (4).…”

“…In following this line of investigation, it was demonstrated that sections of methylcholanthrcne-induced murine sarcoma would adsorb human, guinea pig and chicken, but not sheep or bovine erythrocytes (4). A similar hemadsorption phenomenon was ob served in studying cell cultures of the sarcoma (4). It was further demonstrated that sheep erythrocytes, which were negative in these experiments, gave positive hemadsorption tests with either sections or cultures of murine sarcoma, if they were used following sensitiza tion by anti-sheep erythrocyte serum of rabbit or murine origin (5,6).…”