Helminths in organ transplantation

Cooper, Andrew J.; Dholakia, Shamik; Holland, Celia V.; Friend, Peter J.

doi:10.1016/s1473-3099(16)30533-3

Cited by 22 publications

(13 citation statements)

References 135 publications

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“…Infection occurs when humans come into contact with soil that is contaminated with filariform larvae, which then penetrate the skin and enter the lymphatic system. Infection with this organism is particularly dangerous for transplant recipients, as they can develop S. stercoralis hyperinfection syndrome from proliferative larval production and migration, leading to disseminated disease and the potential for life-threatening bacterial gut translocation [60].…”

Section: Parasitesmentioning

confidence: 99%

Infectious Complications in Lung Transplant Recipients

Trachuk

Bartash

Abbasi

et al. 2020

Lung

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Section: Parasitesmentioning

confidence: 99%

Infectious Complications in Lung Transplant Recipients

Trachuk

Bartash

Abbasi

et al. 2020

Lung

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“…Therefore, infected patients can be considered as suitable recipients. Nevertheless, careful selection of kidney donors and recipients with appropriate antischistosomal treatment for at least one month before transplantation are highly recommended [ 236 , 237 ].…”

Section: Discussionmentioning

confidence: 99%

“…As regards echinococcosis (cystic and alveolar) , transplantation of the involved organ should be regarded as a valuable treatment option. Recurrence inside and/or outside the transplanted organ is possible [ 199 , 200 , 201 , 202 , 203 , 237 ].…”

Section: Discussionmentioning

confidence: 99%

Solid Organ Transplant and Parasitic Diseases: A Review of the Clinical Cases in the Last Two Decades

2018

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The aim of this study was to evaluate the occurrence of parasitic infections in solid organ transplant (SOT) recipients. We conducted a systematic review of literature records on post-transplant parasitic infections, published from 1996 to 2016 and available on PubMed database, focusing only on parasitic infections acquired after SOT. The methods and findings of the present review have been presented based on the Preferred Reporting Items for Systematic Reviews and Meta-Analysis (PRISMA) checklist. From data published in the literature, the real burden of parasitic infections among SOT recipients cannot really be estimated. Nevertheless, publications on the matter are on the increase, probably due to more than one reason: (i) the increasing number of patients transplanted and then treated with immunosuppressive agents; (ii) the “population shift” resulting from immigration and travels to endemic areas, and (iii) the increased attention directed to diagnosis/notification/publication of cases. Considering parasitic infections as emerging and potentially serious in their evolution, additional strategies for the prevention, careful screening and follow-up, with a high level of awareness, identification, and pre-emptive therapy are needed in transplant recipients.

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“…Immunocompromised patients are at risk of developing hyperinfection syndrome and disseminated strongyloidiasis that can be fatal, mostly due to Gram-negative bacteremia and sepsis [ 3 , 4 ]. Severe strongyloidiasis typically follows corticosteroid therapy, but has also been described in patients with lymphoma, leukemia, human T-cell lymphotropic virus (HTLV) and HIV infection, malnutrition, chronic renal failure and end-stage renal disease, alcoholism, diabetes mellitus, advanced age, and in solid organ transplant recipients [ 2 , 3 , 4 , 5 , 6 , 7 , 8 ]. Therefore, it is mandatory to diagnose and treat chronic carriers, in order to prevent the hyperinfection syndrome if immunosuppressive treatment is planned [ 3 , 4 , 5 , 6 , 7 , 8 ].…”

Section: Discussionmentioning

confidence: 99%

Strongyloides stercoralis Hyperinfection in an HIV-Infected Patient Successfully Treated with Subcutaneous Ivermectin

et al. 2018

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A 39-year-old Ethiopian HIV-positive man with peripheral T-cell lymphoma developed Strongyloides stercoralis hyperinfection. The patient was initially treated with oral ivermectin for three weeks without response, most likely due to malabsorption because of concomitant paralytic ileus. Given the persistence of larvae in the body fluids, the worsening respiratory status and clinical malabsorption, veterinary parenteral formulation of ivermectin was administered. The very high plasma concentration of ivermectin achieved in the patient after parenteral administration led to a rapid improvement in his clinical condition and rapid disappearance of the parasite from biological samples, without any adverse reaction.

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Helminths in organ transplantation

Cited by 22 publications

References 135 publications

Infectious Complications in Lung Transplant Recipients

Infectious Complications in Lung Transplant Recipients

Solid Organ Transplant and Parasitic Diseases: A Review of the Clinical Cases in the Last Two Decades

Strongyloides stercoralis Hyperinfection in an HIV-Infected Patient Successfully Treated with Subcutaneous Ivermectin

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