Helminthic Infection Down‐Regulates Type 1 Immune Responses in Human T Cell Lymphotropic Virus Type 1 (HTLV‐1) Carriers and Is More Prevalent in HTLV‐1 Carriers than in Patients with HTLV‐1–Associated Myelopathy/Tropical Spastic Paraparesis

Porto, Aurélia F.; Santos, Sara; Muniz, André Luiz; Basilio, Vanessa; Rodrigues, Waldyr; Neva, Franklin A.; Dutra, Walderez O.; Gollob, Kenneth J.; Jacobson, Steven; Carvalho, Edgar M.

doi:10.1086/427560

Cited by 34 publications

(39 citation statements)

References 31 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…As HTLV-1 is able to induce an exacerbated immune response and this is the basis of the pathology [8], strategies capable of reducing the Th1-inflammatory response are desirable. A previous study conducted by the Immunology Service of the Federal University of Bahia showed that in HTLV-1-infected individuals coinfected with S. mansoni , the levels of IFN-γ in the supernantants of nonstimulated PBMC cultures were higher when compared to HTLV-1 non-coinfected individuals [16]. …”

Section: Discussionmentioning

confidence: 99%

Schistosoma Antigens Downmodulate the in vitro Inflammatory Response in Individuals Infected with Human T Cell Lymphotropic Virus Type 1

Lima

Santos

Oliveira

et al. 2013

Neuroimmunomodulation

View full text Add to dashboard Cite

Human T cell lymphotropic virus type 1 (HTLV-1) is the causal agent of HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP). While the immune response to HTLV-1 infection is polarized to the Th1-type, chronic helminth infections drive the Th2- and T regulatory-type, and are able to downregulate the inflammatory response in some autoimmune diseases. Objective: To evaluate whether Schistosoma spp. antigens alter the in vitro cytokine response in HTLV-1 infection. Methods: The recombinant Schistosoma antigens Sm29 and ShTSP2 (tetraspanin) and PIII, a fraction of the Schistosoma mansoni adult worm antigen were added to peripheral blood mononuclear cell (PBMC) cultures of HTLV-1-infected individuals and the levels of interferon (IFN)-γ and interleukin (IL)-10 in the supernatants were measured using the ELISA sandwich technique. Results: Compared to the levels of cytokine in nonstimulated cultures, the levels of IFN-γ were reduced in 50, 47 and 50% of patients by the presence of Sm29, ShTsp2 and PIII, respectively. The downregulation of IFN-γ production in the presence of Sm29 antigen was observed mainly in subjects who had lower basal levels of this cytokine. The levels of IL-10, however, increased by the addition of the three antigens in the cultures in 74, 62 and 44% of individuals, respectively. In addition, there was a decrease in the ratio of IFN-γ/IL-10 levels in cultures stimulated with Sm29 and ShTSP2 when compared to nonstimulated ones. Conclusions: The Schistosoma spp. antigens used in this study were able to downmodulate IFN-γ production in vitro in HTLV-1 infection. This may be associated with the increased levels of IL-10 induced by the antigens.

show abstract

Section: Discussionmentioning

confidence: 99%

Schistosoma Antigens Downmodulate the in vitro Inflammatory Response in Individuals Infected with Human T Cell Lymphotropic Virus Type 1

Lima

Santos

Oliveira

et al. 2013

Neuroimmunomodulation

View full text Add to dashboard Cite

show abstract

“…Some studies have suggested that S. stercoralis infection promotes development of ATL in HTLV-1 infected individuals [8,9,10], but this hypothesis has been disputed on the grounds that ATL patients infected with Strongyloides have improved responses to chemotherapy [11], and HTVL-1 carriers coinfected with Strongyloides have a lower proviral loads than those with HTVL-1 alone [12]. …”

Section: Discussionmentioning

confidence: 99%

Disseminated Strongyloides stercoralis Infection in HTLV-1-Associated Adult T-Cell Leukemia/Lymphoma

et al. 2011

View full text Add to dashboard Cite

A 55-year-old woman with human T-cell lymphotropic virus type-1 (HTLV-1)-associated adult T-cell leukemia (ATL) and a history of previously treated Strongyloides stercoralis infection received anti-CD52 monoclonal antibody therapy with alemtuzumab on a clinical trial. After an initial response, she developed ocular involvement by ATL. Alemtuzumab was stopped and high-dose corticosteroid therapy was started to palliate her ocular symptoms. Ten days later, the patient developed diarrhea, vomiting, fever, cough, skin rash, and a deteriorating mental status. She was diagnosed with disseminated S. stercoralis. Corticosteroids were discontinued and the patient received anthelmintic therapy with ivermectin and albendazole with complete clinical recovery.

show abstract

“…The synergistic severity of disease caused by these infections has been suggested to be due to immunocompromise resulting from HTLV-1 as a result of interferon g expression, and shift from Th2 to Th1 responses, resulting in decreased levels of IL4, IL5, IL13, and IgE [4,[16][17][18][19]. Alternatively, a Strongyloides antigen has been postulated to induce a potent polyclonal T-cell mitogenic response, and reactivation of HTLV-1 expression [1,20].…”

Section: Discussionmentioning

confidence: 99%

Effect of treatment of Strongyloides infection on HTLV‐1 expression in a patient with adult T‐cell leukemia

et al. 2007

View full text Add to dashboard Cite

Human T-cell leukemia virus type 1 (HTLV-1) is associated with adult T-cell leukemia-lymphoma (ATLL) in about 5% of infected individuals. Coinfection by Strongyloides stercoralis has been suggested to be a cofactor for development of ATLL. We describe a patient who presented with HTLV-1-associated chronic ATLL and Strongyloides infection. Studies of this patient's viral RNA levels demonstrated stimulation of HTLV-1 replication by Strongyloides, which resolved with anti-helminthic therapy. This case provides support for the hypothesis that Strongyloides is a cofactor for ATLL via T-cell stimulation. Am. J. Hematol. 82:929-931, 2007. V

show abstract

Helminthic Infection Down‐Regulates Type 1 Immune Responses in Human T Cell Lymphotropic Virus Type 1 (HTLV‐1) Carriers and Is More Prevalent in HTLV‐1 Carriers than in Patients with HTLV‐1–Associated Myelopathy/Tropical Spastic Paraparesis

Cited by 34 publications

References 31 publications

<b><i>Schistosoma</i></b> Antigens Downmodulate the in vitro Inflammatory Response in Individuals Infected with Human T Cell Lymphotropic Virus Type 1

<b><i>Schistosoma</i></b> Antigens Downmodulate the in vitro Inflammatory Response in Individuals Infected with Human T Cell Lymphotropic Virus Type 1

Disseminated <i>Strongyloides stercoralis</i> Infection in HTLV-1-Associated Adult T-Cell Leukemia/Lymphoma

Effect of treatment of Strongyloides infection on HTLV‐1 expression in a patient with adult T‐cell leukemia

Contact Info

Product

Resources

About