Heligmosomoides polygyrus: Inoculum size and glucose, ion, and gas fluxes in the small intestine of mice

Hsu, S. C.; Sukhdeo, M. V. K.; Mettrick, D. F.

doi:10.1016/s0014-4894(85)80022-9

Cited by 7 publications

(1 citation statement)

References 28 publications

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“…This occurs despite differences in the impact of the infection on intestinal morphology; however, the inoculation doses were chosen to induce a vigorous host response that leads to parasite expulsion without overt clinical expression of disease. These data agree with work of others reporting alterations in hexose transport in the small intestine in Hp (19) and in hexose or mannitol transport in Tsp (20 -22) and with the observed increase in luminal fluid in the jejuna of Nb rats on days 7 and 10 postinfection (23). We reported previously that treatment of BALB/c mice with either IL-4 or IL-13 induced a significant reduction in glucose absorption (24).…”

Section: Discussionsupporting

confidence: 93%

Enteric Nematodes Induce Stereotypic STAT6-Dependent Alterations in Intestinal Epithelial Cell Function

Madden

Yeung

Zhao

et al. 2004

The Journal of Immunology

104

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Infection with gastrointestinal nematodes exerts profound effects on both the immune and physiological responses of the host. We showed previously that the Th2 cytokines, IL-4 and IL-13, induce STAT6-dependent changes in intestinal epithelial cell permeability, absorption, and secretion that are similar to those observed in a secondary infection with Heligmosomoides polygyrus. In the current study we investigated whether nematode-induced effects on epithelial cell function were 1) generic, 2) dependent upon STAT6, and 3) attributable to direct effects on the epithelial cells themselves or mediated by effects on enteric nerves. Our results demonstrate that infection of BALB/c mice with three different gastrointestinal nematodes (H. polygyrus, Nippostrongylus brasiliensis, and Trichinella spiralis) alters intestinal epithelial cell function by decreasing resistance, glucose absorption, and secretory responses to 5-hydroxytryptamine and acetylcholine, two critical mediators in the submucosal reflex pathway. These modified responses are dependent on STAT6 and are the result of both direct effects and indirect effects mediated through enteric nerves.

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Section: Discussionsupporting

confidence: 93%