Helicobacter species are associated with possible increase in risk of biliary lithiasis and benign biliary diseases

Pandey, Manoj

doi:10.1186/1477-7819-5-94

Cited by 17 publications

(14 citation statements)

References 27 publications

(22 reference statements)

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“…9 Evidence supporting the association between H. pylori infection and gallbladder diseases can be found by using a direct culture or staining method of H. pylori in gallbladder tissue, as well as indirect techniques, such as the polymerase chain reaction, enzyme-linked immunosorbent assay (ELISA), and serology for the detection of H. pylori-specific antibodies. [10][11][12] The H. pylori positive rate in the gallbladder is reported to be approximately 10-20% by culture, 13 and the presence of H. pylori in the gallbladder mucosa was first confirmed by Kawaguchi et al in 1996. 14 Although H. pylori has been found to occur 3.5 times more frequently in chronic cholecystitis, whether it contributes to the pathogenesis of biliary disease is still poorly understood.…”

Section: Introductionmentioning

confidence: 99%

Association between Helicobacter pylori infection and gallbladder diseases: A retrospective study

Yuan

et al. 2018

J of Gastro and Hepatol

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Section: Introductionmentioning

confidence: 99%

Association between Helicobacter pylori infection and gallbladder diseases: A retrospective study

Yuan

et al. 2018

J of Gastro and Hepatol

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“…Our previous meta-analysis demonstrated that Helicobacter pylori ( H.pylori ) in human biliary system was correlated with chronic cholecystitis, especially in the regions with higher prevalence of this infectious agent such as South Asia, East Asia and Latin America. [6] Evidences supporting the association between H.pylori infection and chronic cholecystitis could be found by using direct culture or staining of H.pylori in gallbladder tissues as well as indirect techniques such as PCR, ELISA and serology for detecting H.pylori -specific genes or antibodies [7]–[9]. The positive rate of H.pylori in gallbladder is reported to be 10%–20% by culture.…”

Section: Introductionmentioning

confidence: 99%

A Comparative Study of Clinicopathological Features between Chronic Cholecystitis Patients with and without Helicobacter pylori Infection in Gallbladder Mucosa

et al. 2013

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Background Helicobacter pylori has been isolated from 10%–20% of human chronic cholecystitis specimens but the characteristics of “Helicobacter pylori positive cholecystitis” remains unclear. This study aims to compare the clinicopathological features between chronic cholecystitis patients with and without Helicobacter pylori infection in gallbladder mucosa.MethodsThree hundred and twenty-six chronic cholecystitis patients were divided into two groups according to whether Helicobacter pylori could be detected by culture, staining or PCR for Helicobacter 16s rRNA gene in gallbladder mucosa. Positive samples were sequenced for Helicobacter pylori-specific identification. Clinical parameters as well as pathological characteristics including some premalignant lesions and the expression levels of iNOS and ROS in gallbladder were compared between the two groups.Results Helicobacter pylori infection in gallbladder mucosa was detected in 20.55% of cholecystitis patients. These patients had a higher prevalence of acid regurgitation symptoms (p = 0.001), more histories of chronic gastritis (p = 0.005), gastric ulcer (p = 0.042), duodenal ulcer (p = 0.026) and higher presence of Helicobacter pylori in the stomach as compared to patients without Helicobacter pylori infection in the gallbladder mucosa. Helicobacter pylori 16s rRNA in gallbladder and gastric-duodenal mucosa from the same individual patient had identical sequences. Also, higher incidences of adenomyomatosis (p = 0.012), metaplasia (p = 0.022) and higher enhanced expressions of iNOS and ROS were detected in Helicobacter pylori infected gallbladder mucosa (p<0.05).Conclusions Helicobacter pylori infection in gallbladder mucosa is strongly associated with Helicobacter pylori existed in stomach. Helicobacter pylori is also correlated with gallbladder premalignant lesions including metaplasia and adenomyomatosis. The potential mechanism might be related with higher ROS/RNS production but needs further investigation.

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“…in biliary tract and stone diseases. Some reported strong positive correlation while others indicated totally negative results [7]–[9]. To understand these controversial findings, the following three premises should be concerned.…”

Section: Introductionmentioning

confidence: 99%

Are Helicobacter Pylori and Other Helicobacter Species Infection Associated with Human Biliary Lithiasis? A Meta-Analysis

et al. 2011

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BackgroundSince the isolation of Helicobacter species in biliary system, a hypothetical question was raised about the role of these agents in the development of cholelithiasis. This meta-analysis is to explore the association between the Helicobacter infection and biliary lithiasis.Methodology/Principal FindingsA systematic literature search was performed to identify all eligible articles. Meta-analysis which was carried out using odds ratio and random effect model, 95% confidence intervals for odds ratio was calculated. Quantitative assessment of heterogeneity was explored by chi-square test with significance set at P value 0.10 and was measured using I 2 statistic. Eighteen studies published between 1998 and 2011 were finally eligible for meta-analysis. H. Pylori, H. Bilis, H. Hepaticus, H. Pullorum and H. Ganmani were studied. With heterogeneity (I2 = 69.5%, P<0.0001), significantly higher pooled infection rates of H. Pylori (OR: 2.59, 35.82% versus 26.75%, P = 0.01) and H. Hepaticus (OR: 3.13, 31.30% versus 12.12%, P = 0.02) were observed in lithiasis group. Higher prevalence of H. Pylori in cholelithiasis patients were reported by studies from East Asia, South Asia and South America. Evidences supporting the higher presence of H. Pylori in cholelithiasis patients could be found by PCR for detecting 16s rRNA in bile, 26kDa protein gene in biliary tissue and immunohistochemistry. Using multiple detection tests could increase the detection rate of H. Pylori.Conclusions/SignificancesOur meta-analysis suggests a trend of higher presence of H. Pylori in cholelithiasis patients than control group and this trend was significant in the regions with higher prevalence of this agent. Evidences supporting the association between Helicobacter and cholelithiasis could be found by using different tests but the gold standard for the identification of these bacteria in biliary system has yet to be established. Considering obvious heterogeneity, a large multi-center study will facilitate us to further clarify the association between the Helicobacter infection and cholelithiasis.

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Helicobacter species are associated with possible increase in risk of biliary lithiasis and benign biliary diseases

Cited by 17 publications

References 27 publications

Association between Helicobacter pylori infection and gallbladder diseases: A retrospective study

Association between Helicobacter pylori infection and gallbladder diseases: A retrospective study

A Comparative Study of Clinicopathological Features between Chronic Cholecystitis Patients with and without Helicobacter pylori Infection in Gallbladder Mucosa

Are Helicobacter Pylori and Other Helicobacter Species Infection Associated with Human Biliary Lithiasis? A Meta-Analysis

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