Helicobacter pylori: The balance between a role as colonizer and pathogen

Otero, Laura Llorca; Ruiz, Victoria; Perez-Perez, Guillermo I.

doi:10.1016/j.bpg.2014.09.003

Cited by 14 publications

(8 citation statements)

References 92 publications

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“…Endoscopic and PCR data suggest that H. pylori plays no significant role in GM damage in SLE and APS, which agrees with the data available in the literature [14, 49, 73]. It can be said that in patients with SLE and APS, the GM is colonized by H. pylori [74]. At the same time, its value in GM damage in patients with SLE and APS has not been proven.…”

Section: Discussionsupporting

confidence: 74%

The Contribution of Drugs and Helicobacter pylori to Gastric Mucosa Changes in Patients with Systemic Lupus Erythematosus and Antiphospholipid Syndrome

Reshetnyak

Дорошкевич

Середавкина

et al. 2019

International Journal of Rheumatology

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Background. The nature and rate of gastric mucosal (GM) damage in systemic lupus erythematosus (SLE) and antiphospholipid syndrome (APS) remain to be among the unsolved problems. Objective. To define the role of H. pylori and drugs in the development of GM damages in SLE and APS. Methods. A study was conducted on 85 patients with SLE and APS. All the patients underwent esophagogastroduodenoscopy with targeted biopsy of the mucosa of the gastric body and antrum. The presence of H. pylori in the gastric biopsy specimens was determined using polymerase chain reaction. Results. Endoscopic examination revealed that the patients with SLE and APS on admission had the following GM changes: antral gastritis (82.4%), erosions (24.7%), hemorrhages (8.2%), and pangastritis (8.2%). SLE and APS patients showed no direct correlation between the found GM damages and the presence of H. pylori. The use of glucocorticoid, low-dose acetylsalicylic acid, nonsteroidal anti-inflammatory drug, and anticoagulant in SLE and APS patients is accompanied by GM damage. Conclusion. There was no evidence of the role of H. pylori in GM damage in the SLE and APS patients. More frequent detection of H. pylori was observed in anticoagulants or low-dose acetylsalicylic acid users than in glucocorticoids and nonsteroidal anti-inflammatory drugs ones.

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Section: Discussionsupporting

confidence: 74%

The Contribution of Drugs and Helicobacter pylori to Gastric Mucosa Changes in Patients with Systemic Lupus Erythematosus and Antiphospholipid Syndrome

Reshetnyak

Дорошкевич

Середавкина

et al. 2019

International Journal of Rheumatology

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“…Some studies also suggest an inverse correlation of H. pylori infection with childhood asthma or obesity. Thus, it is debatable whether we should consider this bacterium as a colonizer or as a pathogen (Cover and Blaser, 2009 ; Cid et al, 2013 ; Otero et al, 2014 ).…”

Section: Introductionmentioning

confidence: 99%

Diversity of the Epsilonproteobacteria Dsb (disulfide bond) systems

et al. 2015

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The bacterial proteins of the Dsb family—important components of the post-translational protein modification system—catalyze the formation of disulfide bridges, a process that is crucial for protein structure stabilization and activity. Dsb systems play an essential role in the assembly of many virulence factors. Recent rapid advances in global analysis of bacteria have thrown light on the enormous diversity among bacterial Dsb systems. While the Escherichia coli disulfide bond-forming system is quite well understood, the mechanisms of action of Dsb systems in other bacteria, including members of class Epsilonproteobacteria that contain pathogenic and non-pathogenic bacteria colonizing extremely diverse ecological niches, are poorly characterized. Here we present a review of current knowledge on Epsilonproteobacteria Dsb systems. We have focused on the Dsb systems of Campylobacter spp. and Helicobacter spp. because our knowledge about Dsb proteins of Wolinella and Arcobacter spp. is still scarce and comes mainly from bioinformatic studies. Helicobacter pylori is a common human pathogen that colonizes the gastric epithelium of humans with severe consequences. Campylobacter spp. is a leading cause of zoonotic enteric bacterial infections in most developed and developing nations. We focus on various aspects of the diversity of the Dsb systems and their influence on pathogenicity, particularly because Dsb proteins are considered as potential targets for a new class of anti-virulence drugs to treat human infections by Campylobacter or Helicobacter spp.

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“…H. pylori might be a regular member in the gastric microflora in human. With the improvement of environment and lifestyle, and the eradication of H pylori, the prevalence of H. pylori infection in the developed countries has declined sharply, while the incidence of asthma, obesity, and allergic diseases has increased rapidly [137][138][139]. According to Blazer [140], the proponent of the "disappearing microbiota" hypothesis, the absence of certain bacterial species from the ancestral microbiota could change the environment where cognitive, metabolic, and immunological functions develop in our early life.…”

Section: Reducing the Expression Of Heat Shock Protein 70mentioning

confidence: 99%

The Protective Effects of Helicobacter pylori Infection on Allergic Asthma

Zuo¹,

Yue²,

Sun³

et al. 2020

Int Arch Allergy Immunol

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As an ancient Gram-negative bacterium, Helicobacter pylori has settled in human stomach. Eradicating H. pylori increases the morbidities of asthma and other allergic diseases. Therefore, H. pylori might play a protective role against asthma. The “disappearing microbiota” hypothesis suggests that the absence of certain types of the ancestral microbiota could change the development of immunology, metabolism, and cognitive ability in our early life, contributing to the development of some diseases. And the Hygiene Hypothesis links early environmental and microbial exposure to the prevalence of atopic allergies and asthma. Exposure to the environment and microbes can influence the growing immune system and protect subsequent immune-mediated diseases. H. pylori can inhibit allergic asthma by regulating the ratio of helper T cells 1/2 (Th1/Th2), Th17/regulatory T cells (Tregs), etc. H. pylori can also target dendritic cells to promote immune tolerance and enhance the protective effect on allergic asthma, and this effect relies on highly suppressed Tregs. The remote regulation of lung immune function by H. pylori is consistent with the gut-lung axis theory. Perhaps, H. pylori also protects against asthma by altering levels of stomach hormones, affecting the autonomic nervous system and lowering the expression of heat shock protein 70. Therapeutic products from H. pylori may be used to prevent and treat asthma. This paper reviews the possible protective influence of H. pylori on allergic asthma and the possible application of H. pylori in treating asthma.

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Helicobacter pylori: The balance between a role as colonizer and pathogen

Cited by 14 publications

References 92 publications

The Contribution of Drugs and Helicobacter pylori to Gastric Mucosa Changes in Patients with Systemic Lupus Erythematosus and Antiphospholipid Syndrome

The Contribution of Drugs and Helicobacter pylori to Gastric Mucosa Changes in Patients with Systemic Lupus Erythematosus and Antiphospholipid Syndrome

Diversity of the Epsilonproteobacteria Dsb (disulfide bond) systems

The Protective Effects of <b><i>Helicobacter pylori</i></b> Infection on Allergic Asthma

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