Helicobacter pylori seropositivity protects against childhood asthma and inversely correlates to its clinical and functional severity

Fouda, Eman; Kamel, Terez Boshra; Nabih, Enas Samir; Abdelazem, A.A.

doi:10.1016/j.aller.2017.03.004

Cited by 25 publications

(27 citation statements)

References 37 publications

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“…This supports data from a smaller case‐control study showing a nonsignificant lower H. pylori positivity among children with allergies compared with individuals without allergies: 13.9% (17/122) vs 22.4% (22/98), respectively . In contrast, 2 other case‐control studies showed a significantly lower seroprevalence of H. pylori among allergic children compared with individuals without allergies: 25.6% (23/90) vs 44.4% (40/90) and 20% (36/180) vs 60% (108/180), respectively . In addition, the latter study also demonstrated significantly higher serum IL‐10 levels in nonatopic subjects …”

Section: Clinical Manifestationssupporting

confidence: 85%

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Helicobacter pyloriand some aspects of gut microbiota in children

2018

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Helicobacter pylori infection in children differs from infection in adults in many aspects. The rate of infection, epidemiology, clinical presentations and complications, the applicability of diagnostic tests, antibiotic resistance, treatment options, and success rates differ significantly. Due to all these differences, management guidelines for children and adults differ also substantially. In 2017, the Updated ESPGHAN and NASPGHAN Guidelines on the management of H. pylori infection in children were published, emphasizing the differences in clinical presentation and indications for treatment, stating that the primary goal of clinical investigation in children is to identify the cause of upper gastrointestinal symptoms rather than the presence of H. pylori infection. Therefore, the diagnosis should be based on upper endoscopy, and the "test and treat strategy" should not be used in children. Due to an increasing rate of antibiotic resistance worldwide, the updated guidelines recommend broader use of antimicrobial susceptibility testing for H. pylori strains in order to tailor eradication treatment accordingly. Moreover, treatment in children should be prescribed only when indicated and should be based on the rate of eradication in local populations aiming for treatment success above 90%. During the last two decades there has been a steady decrease in the rate of H. pylori infection in both children and adults in the Western world. Two recent publications studying the incidence of H. pylori infection confirmed that early childhood is a time for acquisition of infection both in industrialized and nonindustrialized countries. In addition, they showed that H. pylori could be acquired outside the family. In respect to the inverse association between H. pylori and allergy, a longitudinal study demonstrated that early exposure to H. pylori at any age was inversely associated with atopy and allergic conditions.

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Section: Clinical Manifestationssupporting

confidence: 85%

“…Kato et al 11 15 and 20% (36/180) vs 60% (108/180), respectively. 16 In addition, the latter study also demonstrated significantly higher serum IL-10 levels in nonatopic subjects.…”

Section: Iron Deficiency Anemiamentioning

confidence: 94%

Helicobacter pyloriand some aspects of gut microbiota in children

2018

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“…Farelerde yapılan bir çalışmada ise H. pylori'nin iki antijeninin (γ-glutamyl transpeptidase ve VacA) Treg hücreleri uyardığı gösterildi (29). Çok yeni yayınlanan bir çalışmada H. pylori seropozitivitesi astımlı çocuklarda atopik olmayan sağlam çocuklardan anlamlı olarak düşük bulunmuş ve astımın ağırlığı ile de negatif korelasyon göstermiştir (21). Yine ülkemizden bir yeni çalışmada da non-atopik çocuklarda H. pylori seropozitivitesi ve IL-10 düzeyleri yüksek bulunmuştur (17).…”

Section: Discussionunclassified

“…Daha sonra yapılan çalışmalarda hijyen hipotezinin biyolojik temelleri desteklenmiş; çocukluk çağı enfeksiyonlarının T helper (Th) 1 yanıtı artırdığı ve atopi gelişiminde önemli olan Th2 yanıtı baskıladığı gösterilmiştir (7)(8)(9)(10)(11). Hipotezin ilk ortaya atıldığı andan itibaren virüs (9,10,(12)(13)(14)(15)(16), bakteri (2,7,9,10,13,17) ya da parazit (3,(8)(9)(10)(11)13) olmak üzere çeşitli çocukluk çağı enfeksiyonları ile atopi arasındaki ilişki araştırılmış; lehte ve aleyhte birçok sonuçla tartışmaya günümüzde de devam edilmiştir (2,(17)(18)(19)(20)(21).…”

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The Role of Infections in Atopic Diseases in Children

Erdoğan¹,

Duru²,

Elevli³

et al. 2018

Haseki

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ÖzAmaç: Özellikle gelişmiş ülkelerde olmak üzere son 40 yıldır atopik hastalıkların prevalansında artış görülmektedir. Bu durum iyileşen yaşam koşulları nedeni ile enfeksiyonlara maruziyetin azalması ile açıklanmaktadır. Çalışmamızda bazı enfeksiyonların atopik hastalıklar üzerindeki etkisi araştırılmıştır.Yöntemler: Çalışmamıza atopik 50 hasta ile yaş ve cins olarak benzer 46 sağlam çocuk kontrol gurubu olarak alındı. Olguların deri testleri yapıldı ve serum immünoglobulin (Ig) E düzeyleri belirlendi. Hepatit A virüs (HAV), Toxoplasma gondii, Epstein-Barr virüs (EBV) ve sitomegalovirüs (SMV) seropozitivitelerini saptamak için serumda spesifik IgG belirlendi. Helicobacter pylori antijen pozitifliği gaitada arandı.Bulgular: Atopik çocuklarda anti-HAV IgG seropozitivitesi (%30,0) ve H. pylori antijen pozitifliği (%22,0) kontrollerden (sırası ile, %52,1; %47,8) anlamlı olarak daha düşük bulundu. T. gondii, EBV viral kapsid antijeni ve SMV IgG seropozitifliği açısından her iki grupta anlamlı istatistiksel farklılık saptanmadı. Sonuç: HAV ve H. pylori enfeksiyonları atopik hastalıklardan koruyucu enfeksiyonlar olabilir. Ancak genellenebilir sonuçlara ulaşmak için daha geniş ölçekli çalışmalara gereksinim vardır.AnahtarSözcükler:Atopi, alerji, enfeksiyon, hijyen, hepatit A virüs, helicobakter pylori Aim:Especially in the developed countries; there has been an increase in the prevalence of atopic diseases over the past 40 years. This is explained by the improved living conditions and reduced exposure to infections. In this study, effects of some infections on atopic diseases were investigated.Methods: Fifty atopic patients and 46 age-and sex-matched healthy children were included in the study. Skin prick test was performed and serum immunoglobulin (Ig) E levels were determined in all subjects. Serum-specific IgG was investigated to detect seropositivity of hepatitis A virus (HAV), Toxoplasma gondii, Epstein-Barr virus (EBV) and cytomegalovirus (CMV). In addition, Helicobacter pylori feacal antigen test was done.Results: Anti-HAV IgG seropositivity (30.0%) and H. pylori antigen positivity (22.0%) were significantly lower in atopic children than in controls (52.1%, 47.8%, respectively). There was no statistically significant difference between the two groups in seropositivities of T. gondii, EBV viral capsid antigen and CMV IgG. Conclusion:HAV and H. pylori may be protective infections in atopic patients. However, there is a need for larger scale studies to achieve generalizable results.

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“…Similarly, Karakullukcu et al studied the protective role of H. pylori neutrophil‐activating protein on childhood asthma by analyzing its prevalence in both asthmatic and healthy children, showing a higher prevalence in males . From an epidemiologic point of view, Fouda et al, who studied 90 asthmatic children and 90 healthy controls, reported a significantly lower prevalence of H. pylori in the first group (25.6% vs 44.4%) and an inverse correlation between asthma and anti‐ H. pylori IgG titers . Similar results were reported by Taye et al, who enrolled 856 Ethiopian children in their study, showing an inverse relationship between H. pylori infection, CagA positivity, and both atopy and allergic asthma .…”

Section: Respiratory Diseasesmentioning

confidence: 55%

Helicobacter pylori and extragastric diseases

2018

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Many studies have been performed in the last year concerning the potential role of Helicobacter pylori in different extragastric diseases, reinforcing the idea that specific microorganisms may cause diseases even far from the primary site of infection. While the role of H. pylori on idiopathic thrombocytopenic purpura, sideropenic anemia, and vitamin B12 deficiency has been well established, there is a growing interest in other conditions, such as cardiovascular, neurologic, dermatologic, obstetric, immunologic, and metabolic diseases. Concerning neurologic diseases, there is a great interest in cognitive impairment and neurodegeneration. The aim of this review was to summarize the results of the most relevant studies published over the last year on this fascinating topic.

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Helicobacter pylori seropositivity protects against childhood asthma and inversely correlates to its clinical and functional severity

Abstract: Helicobacter pylori seropositivity protects against childhood asthma and inversely correlates to its clinical and functional severity.

Cited by 25 publications

References 37 publications

Helicobacter pyloriand some aspects of gut microbiota in children

Helicobacter pyloriand some aspects of gut microbiota in children

The Role of Infections in Atopic Diseases in Children

Helicobacter pylori and extragastric diseases

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