Helicobacter pylori reinfection with identical organisms: transmission by the patients' spouses.

Abstract

Patients and methods Hpylori eradication in subjects with a history of at least two symptomatic recurrences and an endoscopically confirmed, active duodenal ulcer was achieved with a 12 day regimen of amoxicillin (750 mg three times daily) plus metronidazole (500 mg three times daily), already described elsewhere.5 Additional ranitidine was given for six (or 10) weeks. After ulcer healing and H pylori eradication, control endoscopies were performed on months 4, 8, 14±1, 27±2, and 43±4 after starting treatment or whenever symptoms occurred. If reinfection was detected, the spouse of the reinfected patient was also asked to undergo endoscopy. H PYLORI STATUSAt each endoscopy five biopsy specimens were collected from the antral mucosa. H pylori was identified by the rapid urease test, histological examination, and culture, as already described previously. All sera from each individual patient were tested in duplicate at the same time.H PYLORI TYPING Hpylori strains were stored at -70°C in 0 5 ml horse serum +17% glycerol. If a reinfection occurred, the newly detected strains were compared to the corresponding pretreatment isolates. In addition, the isolates of the reinfected patient's spouse were obtained at the end of the follow up period. Typing was 831 on 9 May 2018 by guest. Protected by copyright.

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