Helicobacter pylori infection selectively increases the risk for carotid atherosclerosis in young males

Zhang, Linfang; Chen, Zhiheng; Xia, Xiujuan; Chi, Jingshu; Li, Huan; Liu, Xiaoming; Li, Rong; Li, Yixi; Liu, Da; Tian, Delin; Wang, Hui; Petroski, Greg; Flaker, Greg C.; Hao, Hong; Liu, Zhenguo; Xu, Canxia

doi:10.1016/j.atherosclerosis.2019.10.005

Cited by 38 publications

(48 citation statements)

References 44 publications

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“…Several observational studies have linked chronic infection with H pylori to ischemic CVD, thrombotic cerebrovascular disease, and peripheral vascular disease 8‐10 . Some previous studies also showed that H pylori infection can increase the risk of CVDs, especially in the early life 11‐13 . However, other studies have suggested that chronic infection with H pylori was not strongly associated with adverse cardiovascular events such as coronary heart disease or stroke after adjusting for age, sex, and other risk factors, nor was CagA‐positive strain strongly associated with coronary heart disease compared to other strains 14‐16 .…”

Section: Introductionmentioning

confidence: 99%

A meta‐analysis of the association between Helicobacter pylori infection and risk of atherosclerotic cardiovascular disease

Wang

Zhang

et al. 2020

Helicobacter

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Background Helicobacter pylori (H pylori) infection may be a risk factor for cardiovascular disease (CVD), but the reported researches have given conflicting results. Aims To investigate the association between H pylori infection and risk of atherosclerotic CVD. Materials and Methods The studies were retrieved in Embase, PubMed, Web of Science (published from Jan 1, 1990, to Jan 31, 2020, language restrictions: English). All studies included used data from case‐control studies and cohort studies of cardiovascular adverse events. Random effect models were used to measure pooled estimates. All data were analyzed with Stata 11.2 SE (StataCorp, College Station, TX). Results Helicobacter pylori infection increased the risk of adverse cardiovascular events by 51% (40 studies, n = 19 691, odd ratio [OR] = 1.51, 95% confidence interval [CI]: 1.34‐1.70). The effect was greater for studies that the type of CVDs was myocardial infarction (MI) and cerebrovascular disease (MI OR = 1.80, 95% CI: 1.42‐2.26, cerebrovascular disease OR = 1.54, 95% CI: 1.27‐1.89). Meanwhile, CagA seropositive H pylori strains were associated with a significantly increased risk of cardiovascular adverse events based on published research data (OR = 1.73, 95% CI: 1.40‐2.14). Conclusion In conclusion, H pylori infection enhanced the risk of atherosclerotic cardiovascular adverse events, especially in some patients with MI and cerebrovascular disease. This study will provide guidance for the targeted prevention and treatment of CVDs. But this association need to be confirmed by more prospective studies.

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Section: Introductionmentioning

confidence: 99%

A meta‐analysis of the association between Helicobacter pylori infection and risk of atherosclerotic cardiovascular disease

Wang

Zhang

et al. 2020

Helicobacter

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“…The data showed that for males with age of <50 years, there was a 22.5% increase in the prevalence of carotid atherosclerosis in the subjects with H. pylori infection compared with the ones without H. pylori infection. These data demonstrated that H. pylori infection selectively increased the risk for carotid atherosclerosis in young males under 50 years old [47]. However, how H. pylori infection could lead to atherosclerosis, and why only in young males is unknown.…”

Section: Helicobacter Pylori Infection and Carotid Atherosclerosismentioning

confidence: 82%

“…Recently, a large patient database of 17,613 adult patients with carotid ultrasound examination and a 13 C-urea breath H. pylori test was analyzed [47]. Based on the study designs, the patients were divided into two groups: a cross-sectional study for single measurement group, and a retrospective cohort study for the patients with follow up measurements up to 5 years.…”

Section: Helicobacter Pylori Infection and Carotid Atherosclerosismentioning

confidence: 99%

Helicobacter pylori Infection and Endothelial Dysfunction

Xia¹,

Zhang²,

Xu³

et al. 2021

Helicobacter Pylori - From First Isolation to 2021

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Endothelial cells play a critical role in maintaining the integrity of vascular structure and function. Endothelial dysfunction is closely associated with the development and progression of cardiovascular diseases (CVDs) like hypertension (HTN) and atherosclerosis. Gut microorganisms significantly contribute to atherosclerosis and related CVDs. Helicobacter pylori (H. pylori) colonizes in human gastric epithelium in a significant portion of general population in the world. Patients with H. pylori infection have significantly increased risk for CVDs including atherosclerosis, HTN, coronary heart disease, and cerebrovascular disease especially in younger patients (< 65 years old). H. pylori infection significantly impairs vascular endothelial function through multiple mechanisms including increased reactive oxygen species production and oxidative stress, inflammation, decreased nitric oxide formation, modification of the expression of cytokines and microRNAs, abnormalities of lipid and glucose metabolisms, and exosomes-mediated pathways. Endothelial dysfunction associated with H. pylori infection is reversible in both animal model and human subjects. Accumulating data suggests that H. pylori infection is an important risk factor for endothelial dysfunction and CVDs especially in young patients. Screening young male population for H. pylori infection and treating accordingly could be an effective approach for early prevention of CVDs especially premature atherosclerosis associated with H. pylori infection.

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“…21 In a prospective Chinese study, including 17 613 patients screened with both carotid ultrasound examination and 13 C-UBT, H pylori infection was an independent risk factor for prevalent and incident carotid atherosclerosis only in males under 50 years (P = .009 and P = .028, respectively). 22 To support the role of H pylori infection in the pathogenesis of CHD via endothelial damage, Li…”

Section: Ard I Ova Scul Ar and Cereb Rova Scul Ar D Is E A S E Smentioning

confidence: 99%

Review: Extragastric diseases andHelicobacter pylori

et al. 2020

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The involvement of Helicobacter pylori infection in many extra‐gastroduodenal manifestations remains a fascinating field of investigation. However, for several of these supposed associations, the potential pathogenic mechanism remains unclear. The present review highlights the main associations of H pylori with extra‐gastroduodenal manifestations reported during the last year. We searched for the most relevant studies on this topic, published between April 2019 and March 2020, identified using the term “Helicobacter” in the MEDLINE/Pubmed database. Consistent data emerged from studies investigating metabolic syndrome and ischaemic cardiovascular diseases. Other reported fields of investigation were hepatology, especially focused on non‐alcoholic steatohepatitis, neurology, including Parkinson’s disease and Alzheimer’s disease, as well as dermatology. Inflammatory bowel disease (IBD), that comprises Crohn’s disease and ulcerative colitis, may originate from a dysregulation of the host’s immune response to commensal bacteria in individuals with genetic predisposition. The reduction of biodiversity and other specific imbalances in the faecal microbiome composition of IBD patients compared to that of healthy controls support this hypothesis. In this context, an inverse correlation between H pylori infection and IBD prevalence has been confirmed. Similar results were found in patients with kidney diseases and allergic manifestations. There are indications of the possible involvement of H pylori infection in metabolic syndrome and ischaemic cardiovascular diseases. However, due to a series of factors linked to study designs and the multifactorial pathogenesis of some diseases, further studies are needed.

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Helicobacter pylori infection selectively increases the risk for carotid atherosclerosis in young males

Cited by 38 publications

References 44 publications

A meta‐analysis of the association between Helicobacter pylori infection and risk of atherosclerotic cardiovascular disease

A meta‐analysis of the association between Helicobacter pylori infection and risk of atherosclerotic cardiovascular disease

Helicobacter pylori Infection and Endothelial Dysfunction

Review: Extragastric diseases andHelicobacter pylori

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