Helicobacter pylori infection of the larynx may be an emerging risk factor for laryngeal squamous cell carcinoma

Gong, Hongli; Shi, Yi; Zhou, Liang; Tao, Lei; Shi, Yong; Cao, Wenjun; Cheng, Lei

doi:10.1007/s12094-012-0879-y

Cited by 34 publications

(36 citation statements)

References 26 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Although they were not healthy, these subjects can be considered meaningful controls (22,23). Prior to sample collection, exclusion criteria for both LSCC patients and control subjects were as follows: (i) use of hormones or antibiotics during the previous 3 months, (ii) an active bacterial or viral infection in another part of the body, or (iii) seropositivity for human immunodeficiency virus (8). The study protocol and informed consent documents were reviewed and approved by the Ethics Committee of the Eye, Ear, Nose, and Throat Hospital of Fudan University (Shanghai, China).…”

Section: Study Design and Subjectsmentioning

confidence: 99%

See 1 more Smart Citation

Microbiota in the Throat and Risk Factors for Laryngeal Carcinoma

Gong

Shi

Zhou

et al. 2014

Appl Environ Microbiol

Self Cite

View full text Add to dashboard Cite

The compositions and abundances of the microbiota in the ecological niche of the human throat and the possible relationship between the microbiota and laryngeal cancer are poorly understood. To obtain insight into this, we enrolled 27 laryngeal carcinoma patients and 28 subjects with vocal cord polyps as controls. For each subject, we simultaneously collected swab samples from the upper throat near the epiglottis (site I) and tissue samples from the vestibulum laryngis to the subglottic region (site II). The microbiota of the throat were fully characterized by pyrosequencing of barcoded 16S rRNA genes. We found 14 phyla, 20 classes, 38 orders, 85 families, and 218 genera in the throats of enrolled subjects. The main phyla were Firmicutes (54.7%), Fusobacteria (14.8%), Bacteroidetes (12.7%), and Proteobacteria (10.6%). Streptococcus (37.3%), Fusobacterium (11.3%), and Prevotella (10.6%) were identified as the three most predominant genera in the throat. The relative abundances of 23 bacterial genera in site I were significantly different from those in site II (P < 0.05). The relative proportions of 12 genera largely varied between laryngeal cancer patients and control subjects (P < 0.05). Collectively, this study outlined the spatial structure of microbial communities in the human throat. The spatial structure of bacterial communities significantly varied in two anatomical sites of the throat. The bacterial profiles of the throat of laryngeal cancer patients were strongly different from those of control subjects, and several of these microorganisms may be related to laryngeal carcinoma.

show abstract

Section: Study Design and Subjectsmentioning

confidence: 99%

“…However, the involvement of other agents, such as genetics, nutrition, life-style, and local microbial ecology conditions, remains uncertain (5-7). It has been reported that human papillomavirus 16 and Helicobacter pylori may be risk factors for laryngeal carcinoma (8,9). …”

mentioning

confidence: 99%

Microbiota in the Throat and Risk Factors for Laryngeal Carcinoma

Gong

Shi

Zhou

et al. 2014

Appl Environ Microbiol

Self Cite

View full text Add to dashboard Cite

show abstract

“…It causes in the laryngeal mucosa just like in the gastric mucosa. Thus, it can be correlated with carcinogenesis and tumor progression [4,29,34].…”

Section: Discussionmentioning

confidence: 99%

“…Amizadeh et al [5] stated that cagA gene was only present in 13.8 % of the case group and 31.9 % of the control group. So, it could be supposed that the microorganism may be an independent risk factor for LSCC as the laryngeal mucosa provides a reservoir for the bacteria [4]. Epidemiological studies revealed a strong relation between cagA positive H. pylori strains and increased risk of gastric carcinogenesis when compared with H. pylori cagA negative strains [37].…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

UreA and cagA genes of Helicobacter pylori in Egyptian patients with laryngeal squamous cell carcinoma and benign laryngeal polyps: a cohort study

Barakat

Nabiel

Ali

et al. 2016

Eur Arch Otorhinolaryngol

View full text Add to dashboard Cite

This work aims to estimate the prevalence of Helicobacter pylori ureA gene and evaluate cagA gene-positive strains in both patients of laryngeal squamous cell carcinoma (LSCC) and those with benign laryngeal polyps. This study included 49 patients confirmed pathologically to have LSCC and 15 patients with benign laryngeal polyps over a period from June 2013 to March 2015. Samples of laryngeal tissue were collected during direct laryngoscope under general anesthesia to be pathologically evaluated followed by analysis for H. pylori detection. Each laryngeal tissue sample was divided into three parts; one for bacteriological examination, the second for pathological examination and the third for PCR to detect both ureA and cagA genes. Out of 49 LSCC samples, 31 (64.6 %) was positive for ureA by PCR. Out of them, 29 samples (93.5 %) were cagA positive. Only three cases (20 %) of the benign laryngeal polyp were ureA positive by PCR and one of them was cagA positive by PCR. By the bacteriological culture, only eight samples (25.8 %) gave growth. All of them were ureA positive and only seven of them were cagA positive. There was a significant association between presence of H. pylori and LSCC as compared to benign laryngeal polyp which may contribute in the pathogenesis of laryngeal carcinoma. These results should be confirmed by further studies over larger number of cases.

show abstract

Association between helicobacter pylori infection and carcinoma of the larynx or pharynx

et al. 2015

Self Cite

View full text Add to dashboard Cite

This study supported the proposition that infection with H. pylori was related to laryngeal carcinoma, specifically in the hospital-based control group and diagnosed by polymerase chain reaction (PCR) or enzyme-linked immunosorbent assay (ELISA). Nevertheless, no significant relationship was discovered between H. pylori infection and pharyngeal cancer. © 2015 Wiley Periodicals, Inc. Head Neck 38: E2291-E2296, 2016.

show abstract

Helicobacter pylori infection of the larynx may be an emerging risk factor for laryngeal squamous cell carcinoma

Cited by 34 publications

References 26 publications

Microbiota in the Throat and Risk Factors for Laryngeal Carcinoma

Microbiota in the Throat and Risk Factors for Laryngeal Carcinoma

UreA and cagA genes of Helicobacter pylori in Egyptian patients with laryngeal squamous cell carcinoma and benign laryngeal polyps: a cohort study

Association between helicobacter pylori infection and carcinoma of the larynx or pharynx

Contact Info

Product

Resources

About