Helicobacter pylori infection is associated with fecal biomarkers of environmental enteric dysfunction but not with the nutritional status of children living in Bangladesh

Abstract

Background Because Helicobacter pylori (H. pylori) infection and Environmental Enteric Dysfunction (EED) follow a similar mode of transmission, there can be a complex interplay between H. pylori infection and EED, both of which can influence childhood growth. We sought to investigate the factors associated with H. pylori infection and identify its relationship with the fecal biomarkers of EED including Myeloperoxidase (MPO), Neopterin (NEO), Calprotectin, Reg1B and Alpha-1 antitrypsin (AAT), and nutritional status of the children. Methodology Data from an ongoing community-based nutrition intervention study was used for this analysis. Total 319 children aged between 12-18 months were evaluated at enrolment and at the end of a 90-day nutrition intervention. Multivariable linear regression with generalized estimating equations was done to examine the association of H. pylori infection with stool biomarker of EED and nutritional status of the children.

Infection with Blastocystis spp. and its association with enteric infections and environmental enteric dysfunction among slum-dwelling malnourished adults in Bangladesh

“…Blastocystis is transmitted through fecal-oral route. Earlier reports documented that unhygienic environmental conditions as well as crowded households of developing countries increases the transmission of enteric pathogens [ 22 ]. Nonetheless, malnourished individuals demonstrate a higher risk of infection with enteropathogens [ 31 ].…”

“…Moreover, there is no data regarding the contribution of Blastocystis in the pathogenesis of Environmental Enteric Dysfunction (EED) among adults living in resource limited settings. EED is another asymptomatic entity known to cause disturbances in normal intestinal function and nutrient absorption, which ultimately leads to impaired physical development [ 21 , 22 ]. Although EED is caused by sustained exposure to fecal pathogens similar to Blastocystis , to date there is no definitive answer regarding the relationship between EED and infection with Blastocystis .…”

Seroprevalence of Helicobacter pylori and its association with metabolic syndrome in a rural community of Bangladesh

“…These findings suggest that the acquisition and persistence of H . pylori infection in the early years of life may exert an adverse impact on intestinal health and induce gut inflammation, resulting in increased intestinal permeability, and may cause malnutrition in adult life 57 …”

“…These findings suggest that the acquisition and persistence of H. pylori infection in the early years of life may exert an adverse impact on intestinal health and induce gut inflammation, resulting in increased intestinal permeability, and may cause malnutrition in adult life. 57 Gut microbiota has been found to play an essential role in the pathogenesis of obesity. 20,21 Dysregulated production of inflammatory adipokines caused by excess or dysfunction of adipose tissue can contribute to the development of IR and obesityrelated metabolic diseases, including NAFLD.…”

Evaluation of Effectiveness of Comprehensive Treatment of Duodenal Ulcer in Children

“…Усе більшої актуальності набуває вивчення регіональних і субрегіональних особливостей частоти хвороб органів травлення серед дітей, окремих факторів, що сприяють їх формуванню, клінічне та економічне обгрунтування доцільності застосування окремих схем ерадикаційної терапії, а також наукове обґрунтування підходів до організації діагностики, лікування і диспансерного спостереження за дітьми з H.pylori-асоційованими хворобами шлунка і дванадцятипалої кишки [10]. Попри численні публікації, присвячені проблемі гелікобактерної інфекції у розвитку низки захворювань травного каналу, вікові аспекти інфікування Н. pylori залишаються недостатньо вивченими та почасти суперечливими [11,14].…”