Helicobacter pylori infection in a healthy population in Spain

Martín-de-Argila, C; Boixeda, D; Cantón, Rafael; N, Mir; Rafael, Luis; Gisbert, J.P.; Arocena, C; Plaza, A García

doi:10.1097/00042737-199612000-00006

Cited by 40 publications

(25 citation statements)

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“…There was not a relationship between the presence of H. pylori antibodies and age, sex, over-crowding, smoking or alcohol consumption. Our results agree with those reported by other authors (16,17). H. pylori is believed to be transmitted from person to person through the oral cavity.…”

Section: Discussionsupporting

confidence: 93%

vacA genotypes in oral cavity and Helicobacter pylori seropositivity among adults without dyspepsia

Fernández‐Tilapa¹,

Axinecuilteco-Hilera²,

Giono-Cerezo³

et al. 2011

Med Oral

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Objective: The aims of this research were to determine the prevalence of Helicobacter pylori and its vacA genotypes in oral cavity in persons without dyspepsia and to establish the association between the presence of H. pylori in oral cavity and oral hygiene. The seroprevalence of anti-H. pylori antibodies and its associated factors were analyzed too. Study design: For the study, 200 adults without dyspepsia symptoms were selected. Dental plaque and saliva samples from each subject were obtained. H. pylori detection in oral samples was carried out by polymerase chain reaction (PCR) and for vacA genotyping a semi-nested and nested PCR was used. The enzyme-linked immunosorbent assay (ELISA) was used to detect anti-H. pylori IgG and IgM. The data were analyzed with Chi square and Fisher exact test and the statistical significance was set to 0.05.Results: Of 200 subjects tested, 124 (62%) were seropositive. H. pylori was detected in the oral cavity of 34 subjects (17%) and vacA allelotypes were typified in 12 of those samples. The s1 allele was detected in 8 (66.7%) samples and in one of them m1 and m2 alleles were found. In four subjects vacA m1 subtypes were found and in two of those both m1 and m2 alleles were detected. The prevalence of H. pylori in oral cavity was higher (l8.5%) among seropositive subjects compared with seronegative persons. No association was found between the presence of H. pylori and oral hygiene habits. Conclusions: The presence of H. pylori in oral cavity is more frequent in seropositive subjects without dyspepsia symptoms and could represent the source of gastric infection and bacterial transmission. The data suggest that more than one H. pylori strain may exist in the mouth of asymptomatic persons.

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Section: Discussionsupporting

confidence: 93%

vacA genotypes in oral cavity and Helicobacter pylori seropositivity among adults without dyspepsia

Fernández‐Tilapa¹,

Axinecuilteco-Hilera²,

Giono-Cerezo³

et al. 2011

Med Oral

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“…We have not detected any differences in prevalence according to gender, which is consistent with the majority of studies in the literature (9,(13)(14)(15)(16)20). In terms of age, our data also coincide with most published studies conducted in developed countries, in which prevalence is seen to rise until it peaks in middle-aged individuals, around 50-60 years (9,14,15,18,20).…”

Section: Discussionsupporting

confidence: 91%

“…The prevalence rate obtained, of 69.1% (95% CI: 61.7-75.1%), is high if we compare it to studies conducted in Catalonia, the Basque Country, Asturias, Andalusia, and Madrid, with results of approximately 50% (9,(16)(17)(18)(19)(20). Nonetheless, it is below the 84% obtained in a study carried out in Guadalajara (21), and similar to the 65.6 and 68% described in the Canary Islands (22) and Cuenca (23), respectively.…”

Section: Discussionmentioning

confidence: 71%

Prevalence of Helicobacter pylori infection in the general adult population of the province of Ourense

García

Diz

Benavides

et al. 2006

Rev. esp. enferm. dig.

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Objectives: to determine the prevalence of Helicobacter pylori infection in the general adult population of the province of Ourense.Material and methods: a cross-sectional study was carried out with a randomly selected populational sample. The diagnosis of Helicobacter pylori infection was reached using the 13 C-urea breath test.Results: three hundred and eighty-three subjects were studied, with a prevalence rate of 69.1% (95% CI: 61.7-75.1%); 69.8% (95% CI: 63.2-76.6%) in males and 68.4% (95% CI: 61.5-75.4%) in females (difference not statistically significant). Prevalence increases with age up to a maximum of 88.4% in the 45-54 years age group, and decreases thereafter to a rate of 57.1% in individuals over the age of 84 years.Conclusion: this study reveals that the prevalence rate of Helicobacter pylori infection is high in the general adult population of the province of Ourense. It increases with age until it peaks in the group of middle-aged individuals and is similar in both sexes.

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“…In the present study, the prevalence of infection was 84.1% (37/44 patients), which represents a significantly higher prevalence (p < 0.01) versus the general healthy population of Madrid, which has been estimated to be around 53% by Martín de Argila et al (35), a study that was performed using serology. Moreover, 61.4% of patients presented with digestive symptoms at the time of their initial visit, which confirms the previously known association between rosacea and gastrointestinal symptomatology.…”

Section: Resultscontrasting

confidence: 44%

Effect of Helicobacter pylori eradication therapy in rosacea patients

Miquel

Romero

Sequeiros

et al. 2006

Rev. esp. enferm. dig.

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Objective: the causal relation between rosacea and Helicobacter pylori infection is discussed. We evaluated the clinical evolution of rosacea after infection eradication.Patients and methods: we have prospectively studied 44 patients diagnosed with rosacea. Helicobacter pylori infection was determined, and infected patients were treated with eradication therapy. The evolution of dermatological symptoms in a subgroup of 29 infected patients in whom eradication had been achieved was followed during 16.8 (± 17.8) months. Median age was 50.6 (± 14.1) years for 22 women (75.9%) and 7 men (24.1%). Clinical response according to gender and clinical subtype of rosacea was evaluated.Results: complete improvement was observed in 10 patients (34.5%; 95% CI: 18.6-54.3%), relevant improvement in 9 (31.1%; 95% CI: 16-51%), poor improvement in 5 (17.2%; 95% CI: 6.5-36.4%), and absence of improvement in 5 cases (17.2%; 95% CI: 6.5-36.4%). No significant differences in dermatological evolution according to sex were observed. Regarding subtype of rosacea there was a relevant improvement in 83.3% (95% CI: 64.1-93.8%) of cases with papulopustular type as opposed to 36.5% (95% CI: 20-56.1%) of cases with erythematous predominance, p = 0.02.Conclusions: based on these results, the relation between Helicobacter pylori and rosacea is supported, and infection should be investigated in these patients because an appreciable percentage of patients diagnosed with rosacea and Helicobacter pylori infection can benefit from eradication therapy, mainly in the papulopustular subtype.

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Helicobacter pylori infection in a healthy population in Spain

Cited by 40 publications

References 0 publications

vacA genotypes in oral cavity and Helicobacter pylori seropositivity among adults without dyspepsia

vacA genotypes in oral cavity and Helicobacter pylori seropositivity among adults without dyspepsia

Prevalence of Helicobacter pylori infection in the general adult population of the province of Ourense

Effect of Helicobacter pylori eradication therapy in rosacea patients

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