Helicobacter pylori infection, garlic intake and precancerous lesions in a Chinese population at low risk of gastric cancer

You, Wei‐Cheng; Zhang, Lian; Gail, Mitchell H.; Ma, Junling; Chang, Yun; Blot, William J.; Li, Jiyou; Zhao, Cai-lin; Liu, Weidong; Li, Huiqing; Hu, Yichen; Bravo, Juan Carlos; Correa, Pelayo; Xu, Guang-wei; Fraumeni, Joseph F.

doi:10.1093/ije/27.6.941

Cited by 86 publications

(56 citation statements)

References 11 publications

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“…16) Helicobacter pylori (HP) infection has been linked to stomach cancer and precancerous stomach lesions. [17][18][19] In vitro, garlic extracts have a potent capacity to eliminate HP. 20) We have no information about HP infection in Yangzhong city, but our data from another high-risk area for stomach cancer (Huaian city of Jiangsu province) indicate that frequent intake of raw garlic and Welsh onion may decrease the OR for HP infection (unpublished results).…”

Section: Discussionmentioning

confidence: 99%

Protective Effect of Allium Vegetables against Both Esophageal and Stomach Cancer: A Simultaneous Case‐referent Study of a High‐epidemic Area in Jiangsu Province, China

Gao

Takezaki

Ding

et al. 1999

Japanese Journal of Cancer Research

166

103

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Section: Discussionmentioning

confidence: 99%

Protective Effect of Allium Vegetables against Both Esophageal and Stomach Cancer: A Simultaneous Case‐referent Study of a High‐epidemic Area in Jiangsu Province, China

Gao

Takezaki

Ding

et al. 1999

Japanese Journal of Cancer Research

166

103

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“…The resulted suggested that; increased consumption dose of allium vegetables (e.g. garlic, onion, shallot, etc) would reduce the risk of stomach cancer by 40% [37]. The results had shown that vegetables of allium family can inhibit the tumor growth, H. pylori infections, and vancomycin resistant S. epidermidis.…”

Section: Discussionmentioning

confidence: 99%

Study of antibacterial activity of selected Iranian plant extracts on Helicobacter pylori

Abachi¹

2013

IOSR-JDMS

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“…pylori infection was determined by 13 C-UBT as described previously (28). Briefly, the baseline breath sample was collected from each participant after an overnight fast.…”

Section: C-ubtmentioning

confidence: 99%

Alterations of Cyclooxygenase-2 Methylation Levels Before and After Intervention Trial to Prevent Gastric Cancer in a Chinese Population

Zhang

Zeng

Nie

et al. 2016

Cancer Prevention Research

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To explore the epigenetic mechanisms underlying the effects of anti-Helicobacter pylori (H. pylori) alone and combined with COX-2 inhibitor (celecoxib), we dynamically evaluated the associations between COX-2 methylation alterations and gastric lesion evolution during the process of interventions. In a total of 809 trial participants COX-2 methylation levels were quantitatively detected before and after treatment. The self-comparison at the same stomach site for each subject showed significant methylation alteration differences among intervention groups (P < 0.001). With placebo group as reference, COX-2 methylation levels were decreased in anti-H. pylori [OR, 3.30; 95% confidence interval (CI), 2.16-5.02], celecoxib (OR, 2.04; 95% CI, 1.36-3.07), and anti-H. pylori followed by celecoxib (OR, 2.10; 95% CI, 1.38-3.17) groups. When stratified by baseline histology, the three active arms significantly decreased COX-2 methylation levels in indefinite dysplasia/dysplasia subjects, and ORs were 3.65 (95% CI, 1.96-6.80) for anti-H. pylori, 2.43 (95% CI 1.34-4.39) for celecoxib, and 2.80 (95% CI, 1.52-5.15) for anti-H. pylori followed by celecoxib, respectively. No additive effect on COX-2 methylation was found for anti-H. pylori followed by celecoxib than two treatments alone. Compared with subjects without methylation reduction, higher opportunity for gastric lesion regression was found in subjects with decreased COX-2 methylation levels, especially for indefinite dysplasia/dysplasia subjects (OR, 1.92; 95% CI, 1.03-3.60). These findings suggest that anti-H. pylori or celecoxib treatment alone could decrease COX-2 methylation levels in gastric mucosa. COX-2 methylation alteration was associated with the regression of indefinite dysplasia/dysplasia, which might serve as a potential biomarker for chemoprevention efficacy. Cancer Prev Res; 9(6); 484-90. Ó2016 AACR.

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Helicobacter pylori infection, garlic intake and precancerous lesions in a Chinese population at low risk of gastric cancer

Abstract: The findings of this study suggest that infection with H. pylori is a risk factor and garlic may be protective, in the development and progression of advanced precancerous gastric lesions in an area of China at relatively low risk of GC.

Cited by 86 publications

References 11 publications

Protective Effect of Allium Vegetables against Both Esophageal and Stomach Cancer: A Simultaneous Case‐referent Study of a High‐epidemic Area in Jiangsu Province, China

Protective Effect of Allium Vegetables against Both Esophageal and Stomach Cancer: A Simultaneous Case‐referent Study of a High‐epidemic Area in Jiangsu Province, China

Study of antibacterial activity of selected Iranian plant extracts on Helicobacter pylori

Alterations of Cyclooxygenase-2 Methylation Levels Before and After Intervention Trial to Prevent Gastric Cancer in a Chinese Population

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