Helicobacter pylori infection and the risk of colorectal carcinoma: a systematic review and meta-analysis

Yang, Fan; Xu, Yuanli; Zhu, Renfei

doi:10.23736/s0026-4806.19.05942-1

Cited by 27 publications

(21 citation statements)

References 40 publications

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“…Our findings are consistent with the results of the positive association between serologic responses to H. pylori proteins and CRC (Butt et al, 2019;Epplein et al, 2013). The results are also consistent with the recent Meta-analyses confirmed the positive association between H. pylori infection and the development of CRC (Chen et al, 2013;Guo & Li, 2014;Hong et al, 2012;Rokkas et al, 2013;Wu et al, 2013;Yang et al, 2019;Zhao et al, 2016;Zhao et al, 2008;Zumkeller et al, 2006), and the findings of the original study in Germany (Zhang et al, 2012), in Korea (Park et al, 2018), and China (Liu et al, 2019). The available Meta-analysis by 2019 has not examined for the subgroups of distal and rectum cancers combined.…”

Section: Discussionsupporting

confidence: 93%

“…In another case-control study, 40% of the controls and 41% of the CRC cases were H. pylori-seropositive and serologic response to H. pylori proteins was associated with CRC among Africa Americans but not in another ethnic group (Butt et al, 2019). Results of nine Meta-analyses (Chen et al, 2013;Guo & Li, 2014;Hong et al, 2012;Rokkas et al, 2013;Wu et al, 2013;Yang et al, 2019;Zhao et al, 2016;Zhao et al, 2008;Zumkeller et al, 2006) for the published studies during 1991-2018, showed that there was a positive association between H. pylori infection and CRC.…”

Section: H Pylori Infection and Colorectal Cancers By Anatomical Locmentioning

confidence: 99%

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H. pylori Infection and Colorectal Cancers by Anatomical Locations

Hang¹,

Minh²,

Học³

et al. 2020

Asian Pac J Cancer Prev

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Background: H. pylori infection may play a role in the development of colorectal cancers (CRC). We aimed to examine the association between H. pylori infection and the risk of CRC by anatomical locations. Methods: We conducted a case-control study on 91 incidence cases of CRC and 224 hospital controls. CRC was determined by histopathological examinations. H. pylori IgG antibody in serum was tested. We collected data on the diet, nutrition, and lifestyle by the validated semi-quantitative food frequency and demographic lifestyle questionnaire. The odds ratio and 95% confidence interval (OR (95%CI) were estimated for CRC and its subgroups. Results: Overall 54.95% of CRC cases and 42.41% of the controls were H. pylori-seropositive, OR (95%CI): 1.56 (0.88, 2.74), p for trend=0.115. Positive dose-response association in quartiles, highest vs lowest, was observed for total CRC, OR (95%CI): 2.14 (1.00, 4.58), p for trend=0.049, for proximal colon, OR (95%CI): 1.52 (0.37, 6.25), p for trend=0.571), and for distal colon and rectum cancers combined, OR (95%CI): 2.38 (1.03, 5.50), p for trend=0.039. Conclusions: There is a positive association between H. pylori and colorectal cancers, especially distal colon and rectum cancers combined, but additional research is needed to determine the underlying mechanism of chronic H. pylori infection-induced CRC in humans.

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Section: Discussionsupporting

confidence: 93%

Section: H Pylori Infection and Colorectal Cancers By Anatomical Locmentioning

confidence: 99%

H. pylori Infection and Colorectal Cancers by Anatomical Locations

Hang¹,

Minh²,

Học³

et al. 2020

Asian Pac J Cancer Prev

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“…H. pylori infection is accepted as the most important cause of gastritis and PUD in humans. Moreover, it is recognized as a risk factor for gastric cancer [15] along with potential involvement in the pathogenesis of several extra-gastric manifestations, ranging from hematological diseases (such as idiopathic thrombocytopenic purpura, iron deficiency anemia), to neurological diseases (for example, Parkinson's disease and other forms of neurodegeneration and dementia) [16][17][18][19].…”

Section: Organic Dyspepsiamentioning

confidence: 99%

Management of Dyspepsia and Gastroparesis in Patients with Diabetes. A Clinical Point of View in the Year 2021

Bonetto

Gruden

Beccuti

et al. 2021

JCM

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Diabetes mellitus is a widespread disease, and represents an important public health burden worldwide. Together with cardiovascular, renal and neurological complications, many patients with diabetes present with gastrointestinal symptoms, which configure the so-called diabetic enteropathy. In this review, we will focus on upper gastrointestinal symptoms in patients with diabetes, with particular attention to dyspepsia and diabetic gastroparesis (DG). These two clinical entities share similar pathogenetic mechanisms, which include autonomic neuropathy, alterations in enteric nervous system and histological abnormalities, such as interstitial cells of Cajal depletion. Moreover, the differential diagnosis may be challenging because of overlapping clinical features. Delayed gastric emptying should be documented to differentiate between DG and dyspepsia and it can be assessed through radioactive or non-radioactive methods. The clinical management of dyspepsia includes a wide range of different approaches, above all Helicobacter pylori test and treat. As regards DG treatment, a central role is played by dietary modification and glucose control and the first-line pharmacological therapy is represented by the use of prokinetics. A minority of patients with DG refractory to medical treatment may require more invasive therapeutic approaches, including supplemental nutrition, gastric electric stimulation, pyloromyotomy and gastrectomy.

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“…Among these infections, 1%-15% develop into certain gastrointestinal diseases, such as peptic ulcers, gastric cancer and gastric mucosa-associated lymphoid-tissue (MALT) lymphoma [8,9]. During the last few decades, H. pylori infection has been proposed to be associated with a range of extra-digestive manifestations, ranging from vascular diseases to hepatopathies and colorectal carcinoma [10,11]. In addition to these H. pylori-related diseases, the association with functional dyspepsia has been also reported [12][13][14].…”

Section: Introductionmentioning

confidence: 99%

The Association between Helicobacter pylori Infection and Irritable Bowel Syndrome: A Meta-Analysis

Kim

Cho

Kwak

2020

IJERPH

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The association of Helicobacter pylori (H. pylori) infection with functional dyspepsia has been well studied. However, the data on the relationship between H. pylori infection and irritable bowel syndrome (IBS) are conflicting. This study aims to elucidate the association between H. pylori infection and IBS. PubMed, Cochrane Library, CINAHL and SCOPUS databases were searched to identify eligible English articles published up to December 2019. Cross-sectional studies, case-control studies and cohort studies reporting both prevalence of H. pylori infection and IBS were selected for the detailed review. The pooled odds ratio (ORs) and their 95% confidence interval (CI) were calculated. A total of 7269 individuals in four cross-sectional studies and six case-control studies were included. The prevalence of H. pylori infection ranged from 12.8% to 73.4% in the control group, and 9.7% to 72.1% in the IBS group. The combined OR for H. pylori infection was 1.10 (95% CI: 0.93-1.29, I 2 : 37.5%). In a subgroup analysis of IBS defined according to Rome criteria, the OR for H. pylori infection was 1.10 (95% CI: 0.93-1.30, I 2 = 31.7%). In this meta-analysis, H. pylori infection was not significantly associated with IBS. Well-designed studies are needed to identify the relationship between H. pylori infection and IBS.

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Helicobacter pylori infection and the risk of colorectal carcinoma: a systematic review and meta-analysis

Cited by 27 publications

References 40 publications

H. pylori Infection and Colorectal Cancers by Anatomical Locations

H. pylori Infection and Colorectal Cancers by Anatomical Locations

Management of Dyspepsia and Gastroparesis in Patients with Diabetes. A Clinical Point of View in the Year 2021

The Association between Helicobacter pylori Infection and Irritable Bowel Syndrome: A Meta-Analysis

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