The Association between Helicobacter pylori Infection and Irritable Bowel Syndrome: A Meta-Analysis

Kim, Yun-A; Cho, Yoon Jeong; Kwak, Sang Gyu

doi:10.3390/ijerph17072524

Cited by 11 publications

(8 citation statements)

References 46 publications

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“…As Clostridium difficile releases toxins that are detrimental to the enteric glial cells, neurons, colonocytes, and enterocytes, it disrupts the gut homeostasis [ 28 ]. Helicobacter pylori is a Gram-negative bacterium normally found in the mucous epithelium of the gut [ 30 ]. This pathogenic microbial was recently reported to cause systemic inflammation, visceral hypersensitivity at the upper GI tract, and increased gut permeability [ 28 , 30 ].…”

Section: Irritable Bowel Syndrome and Gut Dysbiosismentioning

confidence: 99%

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Irritable Bowel Syndrome, Depression, and Neurodegeneration: A Bidirectional Communication from Gut to Brain

et al. 2021

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Patients with irritable bowel syndrome (IBS) are increasingly presenting with a wide range of neuropsychiatric symptoms, such as deterioration in gastroenteric physiology, including visceral hypersensitivity, altered intestinal membrane permeability, and gastrointestinal motor dysfunction. Functional imaging of IBS patients has revealed several abnormalities in various brain regions, such as significant activation of amygdala, thinning of insular and anterior cingulate cortex, and increase in hypothalamic gray matter, which results in poor psychiatric and cognitive outcomes. Interrelations between the enteric and central events in IBS-related gastrointestinal, neurological, and psychiatric pathologies have compelled researchers to study the gut−brain axis—a bidirectional communication that maintains the homeostasis of the gastrointestinal and central nervous system with gut microbiota as the protagonist. Thus, it can be disrupted by any alteration owing to the gut dysbiosis or loss of diversity in microbial composition. Available evidence indicates that the use of probiotics as a part of a balanced diet is effective in the management of IBS and IBS-associated neurodegenerative and psychiatric comorbidities. In this review, we delineate the pathogenesis and complications of IBS from gastrointestinal and neuropsychiatric standpoints while also discussing the neurodegenerative events in enteric and central nervous systems of IBS patients and the therapeutic potential of gut microbiota-based therapy established on clinical and preclinical data.

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Section: Irritable Bowel Syndrome and Gut Dysbiosismentioning

confidence: 99%

“…Helicobacter pylori is a Gram-negative bacterium normally found in the mucous epithelium of the gut [ 30 ]. This pathogenic microbial was recently reported to cause systemic inflammation, visceral hypersensitivity at the upper GI tract, and increased gut permeability [ 28 , 30 ].…”

Section: Irritable Bowel Syndrome and Gut Dysbiosismentioning

confidence: 99%

Irritable Bowel Syndrome, Depression, and Neurodegeneration: A Bidirectional Communication from Gut to Brain

et al. 2021

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“…In the present study, neither FGIDs nor gastric HSV-1 infection was associated with histologically identified gastritis. The literature contains conflicting reports on the association of H. pylori infection with FGIDs [58][59][60][61][62][63][69][70][71]. In our study population, H. pylori was more prevalent in control patients than in case patients and was not associated with FGIDs.…”

Section: Discussionmentioning

confidence: 75%

Gastric herpes simplex virus type 1 infection is associated with functional gastrointestinal disorders in the presence and absence of comorbid fibromyalgia: a pilot case–control study

Duffy

Pridgen²,

Whitley

2022

Infection

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Purpose Animal studies have linked gastric herpesvirus infections to symptoms associated with functional gastrointestinal disorders (FGIDs). Herpesviruses have also been hypothesized to contribute to fibromyalgia (FM), a chronic pain syndrome frequently comorbid with FGIDs. The purpose of this study was to compare the prevalence of gastric herpesvirus infection in patients with FGIDs, with and without comorbid FM, to that of controls. Methods For this pilot case–control study, we enrolled 30 patients who met both the Rome IV diagnostic criteria for one or more FGIDs and the American College of Rheumatology 2010 criteria for FM, 15 patients with one or more FGIDs without comorbid FM, and 15 control patients. Following endoscopic examination, gastric biopsies were analyzed for herpesvirus DNA and protein, Helicobacter pylori infection, and histological evidence of gastritis. Importantly, the viral nonstructural protein ICP8 was used as a marker to differentiate cell-associated actively replicating virus from latent infection and/or free virus passing through the GI tract. Results Gastric herpes simplex virus type 1 (HSV-1) infection, as indicated by ICP8 presence, was significantly associated with FGIDs in the presence (OR 70.00, 95% CI 7.42–660.50; P < .001) and absence (OR 38.50, 95% CI 3.75–395.40; P < .001) of comorbid FM. Neither histological gastritis nor H. pylori infection were found to be associated with FGIDs or FM. Conclusions HSV-1 infection was identified in gastric mucosal biopsies from patients with diverse FGIDs, with and without comorbid FM. Larger, multi-center studies investigating the prevalence of this association are warranted.

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“…Ng QX et al suggested in one meta-analysis that IBS sufferers may have an increased probability of H. pylori infection, but this was not significant statistically 12 . H. pylori infection has not been significantly linked to IBS in a recent meta-analysis 8 .…”

Section: Introductionmentioning

confidence: 90%

Role of Helicobacter Pylori Eradication Using Clarithromycin-Based Triple Therapy in Patients With Irritable Bowel Syndrome

Ramadan

Ahmed²,

Hassan³

2022

Bulletin of Pharmaceutical Sciences. Assiut

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Background: Association between Helicobacter pylori (H. pylori) and irritable bowel syndrome (IBS) remains controversial. We evaluated the changes in symptoms and quality of life (QOL) in IBS patients following H. pylori eradication using clarithromycin-based triple therapy. Methods: Patients with moderate or severe IBS and positive H. pylori stool antigen were included and received clarithromycin-based triple therapy, followed by testing for H. pylori eradication after one month. IBS symptoms and IBS-QOL questionnaire were evaluated at the baseline and after H. pylori eradication. Results: 108 patients had H. pylori eradication. Following eradication, 66 patients reported IBS symptoms improvement, while 42 did not. The improved patients were significantly younger; mean age was 38.1 ± 11.7 (p= 0.03). IBS-C type predominated (42.4%) and postprandial fullness and early satiety as dyspeptic symptoms were higher in the improved group. The non-improved group showed a decrease in IBS-QOL subscales, significantly observed in dysphoria, interference with activity, health worry, and social reaction domains. The total IBS-QOL score was significantly higher in the improved versus the non-improved group (p= 0.000). Conclusion: H. pylori eradication did not improve IBS symptoms or QOL in all patients with IBS. QOL improved in young patients with dyspeptic symptoms and the IBS-C subtype.

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The Association between Helicobacter pylori Infection and Irritable Bowel Syndrome: A Meta-Analysis

Cited by 11 publications

References 46 publications

Irritable Bowel Syndrome, Depression, and Neurodegeneration: A Bidirectional Communication from Gut to Brain

Irritable Bowel Syndrome, Depression, and Neurodegeneration: A Bidirectional Communication from Gut to Brain

Gastric herpes simplex virus type 1 infection is associated with functional gastrointestinal disorders in the presence and absence of comorbid fibromyalgia: a pilot case–control study

Role of Helicobacter Pylori Eradication Using Clarithromycin-Based Triple Therapy in Patients With Irritable Bowel Syndrome

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