Helicobacter pylori infection and the CD14 C(−260)T gene polymorphism in ischemic stroke

Park, Moon Ho; Min, Ji Hyun; Koh, Seong Beom; Kim, Byung Jo; Park, Min Kyu; Park, Kun Woo; Lee, Dae Hie

doi:10.1016/j.thromres.2005.11.007

Cited by 19 publications

(10 citation statements)

References 39 publications

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“…The initial search with the keywords and the subject terms identified a total of 11 studies, of which 7 (Ito et al 2000;Lichy et al 2002;Zee et al 2002;Lalouschek et al 2006;Park et al 2006;Kis et al 2007;Banerjee et al 2008) met the inclusion criteria. Characteristics of the included studies are shown in Table 1.…”

Section: Resultsmentioning

confidence: 99%

“…Among the eligible studies, there was considerable diversity of ethnic groups. The included articles represented studies with Asian populations (Ito et al 2000;Park et al 2006;Banerjee et al 2008), European populations (Lichy et al 2002;Lalouschek et al 2006;Kis et al 2007), and a North American population (Zee et al 2002). Hence, two sub-group meta-analyses were also performed: in the Asian and the European populations.…”

Section: Resultsmentioning

confidence: 99%

“…A study in a South-German population demonstrated that the TT genotype is associated with a risk of atherosclerotic or macroangiopathic stroke (Lichy et al 2002), but other studies failed to find any significant association between CD14 C260T and CVD (Zee et al 2002;Lalouschek et al 2006;Park et al 2006;Kis et al 2007;Banerjee et al 2008). …”

Section: Discussionmentioning

confidence: 99%

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CD14 C260T promoter polymorphism and the risk of cerebrovascular diseases: a meta-analysis

Banerjee

2009

J Appl Genet

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Cerebrovascular diseases (CVD) are dysfunctions of the brain, resulting from diseases of blood vessels supplying the brain. Atherosclerosis is one of the major underlying causes of CVD, in which inflammation plays a crucial role. One of the inflammatory mechanisms contributing to atherogenesis is the activation of monocytes and macrophages, which could be mediated by the bacterial endotoxin lipopolysaccharide (LPS) via its receptor CD14. The C260T (rs2569190) single-nucleotide polymorphism (SNP) in the promoter region of the CD14 gene was implicated in CVD. To assess the role of this SNP in CVD, a comprehensive meta-analysis of the available genetic data was conducted. All the case-control association studies evaluating the role of CD14 C260T in CVD were identified. Of these, 7 studies (comprising a total of 1488 patients and 1600 control subjects) were included in this meta-analysis. To measure the strength of genetic association for the gene variant, the odds ratios (ORs) were calculated using both fixed and random effects for comparisons of the alleles, the genotypes, and the dominant and recessive genotype models. The results showed there was no significant association between the T allele of C260T and the risk of CVD under the fixed effects model, OR = 0.99 (95% CI (0.89, 1.09)), P = 0.84; or the random effects model, OR = 0.99 (95% CI (0.88, 1.11)), P = 0.83. Similar results were obtained for the homozygotes and the dominant and recessive models. In conclusion, the results of this meta-analysis suggest the CD14 C260T polymorphism is not a risk factor for CVD. However, more studies in ethnically varied populations are needed to evaluate in a reliable manner the role of this SNP in CVD susceptibility.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

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CD14 C260T promoter polymorphism and the risk of cerebrovascular diseases: a meta-analysis

Banerjee

2009

J Appl Genet

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“…125 iskemik inmeli hastada yaptıkları bir çalışmada, iskemik inme hastalarının %80'inde ve kontrol grubunun %60'ında H. pylori antikorlarının seropozitif olduğunu saptamışlardır. 11 Bizim çalışmamızda ise H. pylori seroprevalansı hasta grubununda %89 ve kontrol grubunda %97 bulunmuştur. Bu durum, toplumumuzda bu yaş grubunda H. pylori seropozitifliğinin yüksek olmasına bağlanmıştır.…”

Section: Bulgularunclassified

Are Some Chronic Infections Probable Risk Factors for Acute Ischemic Stroke?

Öztürk¹,

Güneş²,

Aytar³

et al. 2013

Turkiye Klinikleri J Med Sci

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“…Some studies have shown the formation of platelet aggregates in H. pylori-infected patients [81] which may explain the association between H. pylori and cardiovascular disease, such as myocardial infarction [82][83][84] and stroke [85,86] although others have failed to show any link [87]. Clinical strains of H. pylori have been shown to induce platelet aggregation in vitro by binding plasma vWF which in turn binds to platelet GPIba triggering an activating response [88,89].…”

Section: Helicobacter Pylori Platelet Interactionsmentioning

confidence: 99%

Platelet–bacterial interactions

Kerrigan

Cox

2009

Cell. Mol. Life Sci.

101

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Many bacteria are capable of interacting with platelets and inducing platelet aggregation. This interaction may be a direct interaction between a bacterial surface protein and a platelet receptor or may be an indirect interaction where plasma proteins bind to the bacterial surface and subsequently bind to a platelet receptor. However, these interactions usually do not trigger platelet activation as a secondary co-signal is also required. This is usually due to specific antibody bound to the bacteria interacting with FcgammaRIIa on the platelet surface. Secreted bacterial products such as gingipains and lipopolysaccharide may also be capable of triggering platelet activation.

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Helicobacter pylori infection and the CD14 C(−260)T gene polymorphism in ischemic stroke

Cited by 19 publications

References 39 publications

CD14 C260T promoter polymorphism and the risk of cerebrovascular diseases: a meta-analysis

CD14 C260T promoter polymorphism and the risk of cerebrovascular diseases: a meta-analysis

Are Some Chronic Infections Probable Risk Factors for Acute Ischemic Stroke?

Platelet–bacterial interactions

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